INT5757

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.73
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN4A)
Anatomy Link Frequency
skeletal muscle 2
tongue 1
mouth 1
flagellum 1
sperm 1
SCN4A (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 28 100.00 Very High Very High Very High
nav1.8 18 100.00 Very High Very High Very High
Nav1.6 14 100.00 Very High Very High Very High
Nav1.7 14 100.00 Very High Very High Very High
Nav1.9 8 100.00 Very High Very High Very High
nav1.3 14 99.78 Very High Very High Very High
Nav1.2 10 99.30 Very High Very High Very High
Nav1.1 16 98.82 Very High Very High Very High
tetrodotoxin 27 98.16 Very High Very High Very High
halothane 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 4 96.56 Very High Very High Very High
Disease 1 96.04 Very High Very High Very High
Myotonic Disorders 4 93.56 High High
Hypopituitarism 3 92.44 High High
Hyperkalemic Periodic Paralysis 5 91.72 High High
Congenital Anomalies 1 87.32 High High
Paralysis 3 84.16 Quite High
Syndrome 1 68.04 Quite High
Malignant Hyperthermia 3 62.96 Quite High
Contracture 1 55.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
subunits SCN1A (Nav1.1, 225 bp), SCN2A (Nav1.2, 297 bp), SCN3A (Nav1.3, 367 bp), SCN4A (Nav1.4, 317 bp), SCN5A (Nav1.5, 294 bp), SCN8A (Nav1.6, 207 bp), SCN9A (Nav1.7, 289 bp), SCN10A (Nav1.8, 347 bp), SCN11A (Nav1.9, 272 bp) and the related isoform SCN7A (Nax, 327 bp) were all expressed in human sperm cDNA (Fig 1).
Gene_expression (expressed) of SCN4A in sperm associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
1) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.98
SCN4A (Nav1.4) was present over the head and the flagellum midpiece, and the most intense immunofluorescence was detected in the post-acrosomal region around the connecting piece.
Gene_expression (present) of SCN4A in flagellum
2) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.47
In contrast to IVCT- cells, IVCT+ cells expressed Na+ currents that were predominantly TTX sensitive even in the absence of added fatty acid, thus showing a relatively large baseline functional expression of SkM1 channels.
Gene_expression (expression) of SkM1 associated with tetrodotoxin
3) Confidence 0.68 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8760064 Disease Relevance 0.18 Pain Relevance 0.50
The DNA polymorphisms detected in the growth hormone skeletal muscle sodium channel complex (GH1-SCN4A) and by flanking polymorphic markers (D17S74 and D17S40) demonstrated no recombinants between the disease phenotypes and this complex.
Gene_expression (detected) of SCN4A in skeletal muscle associated with sodium channel and disease
4) Confidence 0.65 Published 1991 Journal Ann. Neurol. Section Abstract Doc Link 1686388 Disease Relevance 1.23 Pain Relevance 0.35
The SCN4A gene product, hSkM1, is the human homologue of rSkM1, the tetrodotoxin-sensitive sodium channel characteristic of adult rat skeletal muscle.
Gene_expression (product) of SCN4A in skeletal muscle associated with tetrodotoxin and sodium channel
5) Confidence 0.57 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.45
AIMS AND OBJECTIVES: To study Na v 1.7 levels in dental pulpitis pain, an inflammatory condition, and burning mouth syndrome (BMS), considered a neuropathic orofacial pain disorder.
Gene_expression (levels) of Na v 1.7 in mouth
6) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link 20529324 Disease Relevance 0.10 Pain Relevance 0
Immunohistochemistry with visual intensity and computer image analysis were used to evaluate levels of Na v 1.7 in dental pulp tissue samples from the dental pulpitis group, and tongue biopsies from the BMS group.
Gene_expression (levels) of Na v 1.7 in tongue
7) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link 20529324 Disease Relevance 0.07 Pain Relevance 0

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