INT57618

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.61
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GTPBP4) nucleolus (GTPBP4) nucleus (GTPBP4)
GTPase activity (GTPBP4) ribosome biogenesis (GTPBP4) cytoplasm (GTPBP4)
Anatomy Link Frequency
CHO 1
temporal lobe 1
GTPBP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 9 100.00 Very High Very High Very High
agonist 50 99.98 Very High Very High Very High
Neurotransmitter 1 97.48 Very High Very High Very High
Kappa opioid receptor 1 96.96 Very High Very High Very High
Pain 1 93.16 High High
Endogenous opioid 2 80.16 Quite High
Neuropeptide 2 77.68 Quite High
Opioid 20 75.52 Quite High
opioid receptor 30 75.00 Quite High
Analgesic 1 70.68 Quite High
Disease Link Frequency Relevance Heat
Sclerosis 3 98.88 Very High Very High Very High
Convulsion 1 96.72 Very High Very High Very High
Cancer 3 96.58 Very High Very High Very High
Epilepsy 7 95.34 Very High Very High Very High
Glioma 2 94.56 High High
Pain 1 93.16 High High
Disease 2 77.44 Quite High
Prostate Cancer 6 75.00 Quite High
Depression 1 35.16 Quite Low
Headache 3 34.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, the reconstitution of the human 5-HT(1D) receptor-G-protein coupling using baculovirus-infected Sf9 cells made possible the assessment of coupling specificity and the detection of different binding states of the receptor induced by G-protein coupling or ligand binding.
G-protein Binding (binding) of
1) Confidence 0.43 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825383 Disease Relevance 0 Pain Relevance 0.11
Reincorporation after the precipitation step into liposomes made of endogenous lipids issued from CHO membranes or exogenous lipids significantly enhanced the specific agonist binding activity and G-protein coupling.
G-protein Binding (binding) of in CHO associated with agonist
2) Confidence 0.08 Published 2010 Journal Anal. Biochem. Section Abstract Doc Link 20018158 Disease Relevance 0 Pain Relevance 0.25
Pharmacological properties of the naturally occurring Phe-124-Cys variant of the human 5-HT1B receptor: changes in ligand binding, G-protein coupling and second messenger formation.
G-protein Binding (binding) of
3) Confidence 0.06 Published 2000 Journal Pharmacogenetics Section Title Doc Link 11037806 Disease Relevance 0.09 Pain Relevance 0.26
The aim of this study was to analyse whether substitution of phenylalanine in position 124 of the human (h) 5-HT1B receptor by cysteine, a naturally occurring variant of this receptor, modifies not only ligand binding, but also G-protein coupling and second messenger formation.
G-protein Binding (binding) of
4) Confidence 0.06 Published 2000 Journal Pharmacogenetics Section Abstract Doc Link 11037806 Disease Relevance 0.09 Pain Relevance 0.14
The G-protein coupled receptors (GPCRs) recognize a large variety of extracellular molecules (such as hormones, neurotransmitters, growth and developmental factors) and several sensory messages (such as light, odors and pain).
G-protein Binding (recognize) of associated with pain and neurotransmitter
5) Confidence 0.05 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16206286 Disease Relevance 0.38 Pain Relevance 0.14
Patients with temporal lobe epilepsy associated with mesial sclerosis (MTLE) or secondary to tumor or vascular lesion showed enhanced [3H]DAMGO and [3H]forskolin binding, lower DAMGO-stimulated [35S]GTPgammaS binding and no significant changes in nociceptin-stimulated G-protein. [3H]Nociceptin binding was lower in patients with MTLE.
G-protein Binding (binding) of in temporal lobe associated with epilepsy, cancer, orphanin and sclerosis
6) Confidence 0.03 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19573600 Disease Relevance 1.05 Pain Relevance 0.59
Agonists show binding to multiple affinity states of the receptor consistent with the presence of G-protein coupled and uncoupled forms of the expressed receptor.
G-protein Binding (binding) of associated with agonist
7) Confidence 0.01 Published 1994 Journal Life Sci. Section Abstract Doc Link 8201839 Disease Relevance 0 Pain Relevance 0.28
The 5-HT4 receptor belongs to a family of at least 15 receptors, each with different subfamilies that engage different G-protein signaling pathways.
G-protein Binding (engage) of
8) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.10
The particular case of asymmetric activation in which one protomer of a GPCR dimer is not capable of G-protein coupling, whereas the other protomer can bind the G-protein but not the ligand will be denoted by the attribute isTransactivated set to TRUE.
G-protein Binding (bind) of
9) Confidence 0.01 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0

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