INT5762

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Context Info
Confidence 0.57
First Reported 1980
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 6.09
Pain Relevance 5.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
blood 2
gonadotroph 2
brain 2
neural 2
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 31 100.00 Very High Very High Very High
anesthesia 14 100.00 Very High Very High Very High
narcan 8 100.00 Very High Very High Very High
antagonist 61 99.70 Very High Very High Very High
halothane 8 99.52 Very High Very High Very High
Morphine 6 99.48 Very High Very High Very High
electroacupuncture 6 99.00 Very High Very High Very High
bradykinin 13 98.08 Very High Very High Very High
Angina 5 97.76 Very High Very High Very High
gABA 15 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 8 100.00 Very High Very High Very High
Hypertension 54 99.96 Very High Very High Very High
Apoptosis 14 99.36 Very High Very High Very High
Stroke 7 99.00 Very High Very High Very High
Cv General 3 Under Development 5 97.76 Very High Very High Very High
Myocardial Infarction 106 97.44 Very High Very High Very High
Radiation Sickness 3 96.16 Very High Very High Very High
Atherosclerosis 8 95.16 Very High Very High Very High
Cough 7 94.88 High High
Pressure And Volume Under Development 4 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rats dosed with DOCA-salt (which suppresses renin and angiotensin II production): (1) there was no synergism between the hypotensive actions of enalaprilat and doxazosin; (2) doxazosin was more potent than in untreated rats; and (3) enalaprilat lowered blood pressure, suggesting a hypotensive mechanism separate from ACE inhibition.
Negative_regulation (suppresses) of Gene_expression (production) of angiotensin II in blood
1) Confidence 0.57 Published 1992 Journal J. Hypertens. Section Body Doc Link 1315824 Disease Relevance 0.08 Pain Relevance 0
Both angiotensin II and naloxone also produced significant decreases in core temperatures that were not altered by restraint.
Negative_regulation (decreases) of Gene_expression (produced) of angiotensin II associated with narcan
2) Confidence 0.43 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8951958 Disease Relevance 0.15 Pain Relevance 0.36
[Accelerated angiotensinogen gene expression in the rat brain made tolerant to morphine or electroacupuncture stimulation].
Negative_regulation (made) of Gene_expression (expression) of angiotensinogen gene in brain associated with electroacupuncture and morphine
3) Confidence 0.43 Published 1989 Journal Sheng Li Xue Bao Section Title Doc Link 2781313 Disease Relevance 0 Pain Relevance 0.74
The alpha 1-adrenoceptor antagonist prazosin also diminished the pressor and renal and mesenteric vasoconstrictor responses produced by angiotensin II.
Negative_regulation (diminished) of Gene_expression (produced) of angiotensin II associated with antagonist
4) Confidence 0.43 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8960880 Disease Relevance 0.07 Pain Relevance 0.18
[Inhibiting effect of (sarcosine-1-isoleucine-8)-angiotensin II in anesthesized rats].
Negative_regulation ([Inhibiting) of Gene_expression (effect) of angiotensin II associated with anesthesia
5) Confidence 0.43 Published 1987 Journal Rev. Esp. Fisiol. Section Title Doc Link 3616115 Disease Relevance 0 Pain Relevance 0.23
organ damage.5 Our results showed a positive correlation between the cardiac hypertrophy index and Ang II levels (r ?
Negative_regulation (correlation) of Gene_expression (levels) of Ang II associated with coronary heart disease
6) Confidence 0.41 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 1.07 Pain Relevance 0
Thus, inhibiting the production of Ang II with ramipril may similarly reduce apoptosis among neural progenitors within the SGZ following radiation injury.
Negative_regulation (inhibiting) of Gene_expression (production) of Ang II in neural associated with radiation sickness and apoptosis
7) Confidence 0.37 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2825515 Disease Relevance 1.10 Pain Relevance 0.09
When the effect of endogenous angiotensin II was antagonized by saralasin or its production was blocked by enalapril, the AVP response to tilt was reduced.
Negative_regulation (blocked) of Gene_expression (production) of angiotensin II
8) Confidence 0.32 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1922676 Disease Relevance 0.07 Pain Relevance 0.04
Angiotensin receptor blocker–ACE inhibitor combination therapy
Negative_regulation (blocker) of Gene_expression (therapy) of Angiotensin
9) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 1.09 Pain Relevance 0.10
Angiotensin receptor blocker–ACE inhibitor combination therapy
Negative_regulation (inhibitor) of Gene_expression (therapy) of Angiotensin
10) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 1.09 Pain Relevance 0.10
This was indicated by the findings that HR did not decrease following D-Ala-ENK-induced BP increases and that the compensatory decreases in HR following i.v. pressor doses of angiotensin II (ANG II) were markedly attenuated in cats treated with i.v.t.
Neg (not) Negative_regulation (decrease) of Gene_expression (induced) of angiotensin II associated with enkephalin
11) Confidence 0.19 Published 1980 Journal Hypertension Section Abstract Doc Link 7399623 Disease Relevance 0.27 Pain Relevance 1.13
This was indicated by the findings that HR did not decrease following D-Ala-ENK-induced BP increases and that the compensatory decreases in HR following i.v. pressor doses of angiotensin II (ANG II) were markedly attenuated in cats treated with i.v.t.
Neg (not) Negative_regulation (decrease) of Gene_expression (induced) of ANG II associated with enkephalin
12) Confidence 0.19 Published 1980 Journal Hypertension Section Abstract Doc Link 7399623 Disease Relevance 0.32 Pain Relevance 1.13
When either the AVP effects or ANG II synthesis were blocked separately, there was a slight tendency for a compensatory increase of the unimpeded hormonal system.
Negative_regulation (blocked) of Gene_expression (synthesis) of ANG II
13) Confidence 0.17 Published 1992 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1549932 Disease Relevance 0 Pain Relevance 0.53
Consequently, the cardiac output was largely unaffected by the interference with AVP effects and/or ANG II synthesis.
Negative_regulation (interference) of Gene_expression (synthesis) of ANG II
14) Confidence 0.17 Published 1992 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1549932 Disease Relevance 0 Pain Relevance 0.53
Inhibition of the generation of Ang II, whether by ACEI or ARB, should therefore attenuate these deleterious processes.
Negative_regulation (Inhibition) of Gene_expression (generation) of Ang II
15) Confidence 0.13 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.08 Pain Relevance 0
Well explored paracrine systems are: (i) the gonadotroph–lactotroph axis, of which the mediators remain incompletely defined but could be in part angiotensin II, PACAP, N-POMC and calcitonin; (ii) the gonadotroph–somatotroph axis, which is particularly well developed in fish; (ii) a cholinergic system in corticotrophs targeting somatotrophs, lactotrophs and FS cells; (iii) a GABA-ergic system in somatotrophs; (iv) several inhibitory systems targeting gonadotrophs (e.g. galanin and PRL from lactotrophs and ?
Negative_regulation (developed) of Gene_expression (axis) of angiotensin II in gonadotroph associated with gaba
16) Confidence 0.11 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.13
These drugs, widely used in the treatment of hypertension, prevent the formation of angiotensin II and the generation of free radicals, as well as the hydrolysis of bradykinin, enkephalins and endorphins.
Negative_regulation (prevent) of Gene_expression (generation) of angiotensin II associated with hypertension, enkephalin and bradykinin
17) Confidence 0.03 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8871140 Disease Relevance 0.25 Pain Relevance 0.34
ACE inhibitors act within the renin-angiotensin system to prevent the conversion of Ang I to Ang II.
Negative_regulation (prevent) of Gene_expression (conversion) of Ang I
18) Confidence 0.03 Published 1993 Journal J Hypertens Suppl Section Abstract Doc Link 8315523 Disease Relevance 0.47 Pain Relevance 0.19

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