INT57626

Context Info Confidence 0.36 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.79 Pain Relevance 0.75

cytoplasm (HRASLS)

HRASLS (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 6 99.00 Inflammation 40 91.68 antagonist 19 83.00 agonist 5 77.24 depression 10 73.36 alcohol 6 72.40 Crohn's disease 30 71.44 tolerance 9 69.24 Pain 3 55.80 Potency 25 47.12

Disease Link Frequency Relevance Heat INFLAMMATION 38 98.80 Obesity 54 96.16 Thrombosis 2 95.64 Increased Venous Pressure Under Development 4 93.64 Inflammatory Bowel Disease 70 86.88 Renal Failure 1 84.88 Radiation Sickness 1 81.20 Depression 13 73.36 Disease 43 71.44 Diabetes Mellitus 85 71.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

G polymorphism creates a c-MYB binding site, which can activate COX-2 expression, and displays a higher promoter activity [15].

a c Binding (binding) of

1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991351 Disease Relevance 0.49 Pain Relevance 0.13

Glucocorticoids inhibit eicosanoid synthesis primarily by interfering with phospholipase A2 whilst non-steroidal anti-inflammatory drugs prevent prostaglandin/thromboxane synthesis by inhibiting cyclooxygenase.

phospholipase Binding (interfering) of associated with inflammation and cinod

2) Confidence 0.32 Published 1994 Journal Acta Oncol Section Abstract Doc Link 8204269 Disease Relevance 0.71 Pain Relevance 0.30

Regression analysis was used to measure the association between the S-TOFHLA score and each of our four outcomes (A1C, SBP, DBP, and LDL) after controlling for potentially confounding patient characteristics.

A1C Binding (association) of

3) Confidence 0.04 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1559691 Disease Relevance 0.73 Pain Relevance 0.13

Indeed, pretreatment of 25 HCECs with 10 µM PCA-42481 followed by the addition of PAF (10 nM) resulted in minimal mobilization of [Ca2+]i (Figure 4A), indicating effective blockade of the PAF receptor and its subsequent coupling to phospholipase C.

phospholipase Binding (coupling) of

4) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.12

There was a tendency to a positive association between YKL-40 mRNA and A1C (P = 0.0645).

A1C Binding (association) of

5) Confidence 0.00 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.85 Pain Relevance 0.08

General Comments

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