INT57638

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Context Info
Confidence 0.40
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 6.08
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
M-1 2
coronary artery 1
primary motor cortex 1
M1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 25 99.66 Very High Very High Very High
Somatosensory cortex 7 98.96 Very High Very High Very High
Neuropathic pain 9 98.70 Very High Very High Very High
Pain threshold 5 98.08 Very High Very High Very High
Deafferentation 12 97.68 Very High Very High Very High
Transcranial magnetic stimulation 4 95.84 Very High Very High Very High
primary somatosensory cortex 5 94.32 High High
hypoalgesia 1 93.20 High High
epidural 3 91.40 High High
headache 3 90.32 High High
Disease Link Frequency Relevance Heat
Pain 20 99.66 Very High Very High Very High
Coronary Artery Disease 3 99.12 Very High Very High Very High
Neuropathic Pain 9 98.70 Very High Very High Very High
Disorder Of Lipid Metabolism 16 98.60 Very High Very High Very High
Causalgia 12 97.68 Very High Very High Very High
Neuromyelitis Optica 94 95.44 Very High Very High Very High
Disease 14 93.52 High High
Hypoalagesia 1 93.20 High High
Headache 3 90.32 High High
Cv General 3 Under Development 5 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of pain relief by the electrical stimulation of M1 has been under investigation.
Positive_regulation (stimulation) of M1 associated with pain
1) Confidence 0.40 Published 2007 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 17691289 Disease Relevance 1.22 Pain Relevance 1.32
Overall, considering the difficulty in treating central neuropathic pain, trigeminal neuropathic pain and certain types of refractory peripheral pain, the electrical stimulation of M1 is a very promising technique; nearly 60% of the treated patients improved with a higher than 50% pain relief after several months of follow-up and sometimes of a few years in most reports.
Positive_regulation (stimulation) of M1 associated with pain and neuropathic pain
2) Confidence 0.40 Published 2007 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 17691289 Disease Relevance 1.30 Pain Relevance 1.33
The stimulation of the primary motor cortex (M1) has proved to be an effective treatment for intractable deafferentation pain.
Positive_regulation (stimulation) of M1 in primary motor cortex associated with pain and deafferentation
3) Confidence 0.40 Published 2007 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 17691289 Disease Relevance 0.81 Pain Relevance 0.70
In our community male patients with a diagnosis of coronary artery disease and age less than 50 years showed a higher frequency of the M1- allele at the -75-bp site of the Apo A1 gene.
Positive_regulation (frequency) of M1 in coronary artery associated with coronary artery disease and disorder of lipid metabolism
4) Confidence 0.10 Published 1998 Journal Cardiology Section Abstract Doc Link 9892774 Disease Relevance 1.35 Pain Relevance 0.30
Moreover, none of the patients were only positive for M-1 AQP4-IgG and negative for M-23 AQP4-IgG, or had higher titer levels for full length AQP4.
Positive_regulation (positive) of M-1 in M-1
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.60 Pain Relevance 0
Stimulation of M1 decreased capacity to discriminate painful heat without influencing HPT; there was large interindividual variation in rTMS effects in the M1/S1 areas.
Positive_regulation (Stimulation) of M1 associated with pain, primary somatosensory cortex and pain threshold
6) Confidence 0.04 Published 2009 Journal Pain Section Abstract Doc Link 19201092 Disease Relevance 0.54 Pain Relevance 1.21
No accumulation of M-1 was observed in subjects receiving repeated administration of TCV-116.
Neg (No) Positive_regulation (accumulation) of M-1 in M-1
7) Confidence 0.00 Published 1994 Journal Clin Ther Section Abstract Doc Link 8205603 Disease Relevance 0.26 Pain Relevance 0.16

General Comments

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