INT57642

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Context Info
Confidence 0.76
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 26
Total Number 28
Disease Relevance 5.09
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PCSK1) extracellular space (PCSK1) small molecule metabolic process (PCSK1)
Golgi apparatus (PCSK1) embryo development (PCSK1) cellular nitrogen compound metabolic process (PCSK1)
Anatomy Link Frequency
PC-3 5
monocytes 3
amygdala 2
lateral 2
cleavage 1
PCSK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 90 100.00 Very High Very High Very High
Enkephalin 43 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
melanocortin 1 receptor 1 96.72 Very High Very High Very High
cINOD 4 96.08 Very High Very High Very High
TRP channel 2 94.32 High High
Pain 4 92.96 High High
Opioid 3 90.32 High High
sodium channel 2 82.20 Quite High
tetrodotoxin 2 76.32 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 35 99.98 Very High Very High Very High
Reprotox - General 1 13 99.96 Very High Very High Very High
Pox Virus Infection 3 99.44 Very High Very High Very High
Metastasis 6 97.36 Very High Very High Very High
Stress 60 90.84 High High
INFLAMMATION 10 90.52 High High
Apoptosis 7 88.52 High High
Cancer 2 85.72 High High
Bladder Cancer 2 64.60 Quite High
Aging 10 48.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PC3 expression was confirmed by Western blotting in THP-1 cells.
Gene_expression (expression) of PC3 in THP-1
1) Confidence 0.76 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.07
Undifferentiated human monocytes do not express carboxypeptidase E (CPE), prohormone convertase 3 (PC3/PC1) or proenkephalin (ENK), suggesting that gene induction during differentiation results in the expression of these genes.
Neg (not) Gene_expression (express) of prohormone convertase 3 in monocytes
2) Confidence 0.76 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.07
Undifferentiated human monocytes do not express carboxypeptidase E (CPE), prohormone convertase 3 (PC3/PC1) or proenkephalin (ENK), suggesting that gene induction during differentiation results in the expression of these genes.
Neg (not) Gene_expression (express) of PC3 in monocytes
3) Confidence 0.76 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.07
Expression of PC3, carboxypeptidase E and enkephalin in human monocyte-derived macrophages as a tool for genetic studies.
Gene_expression (Expression) of PC3 in monocyte associated with enkephalin
4) Confidence 0.76 Published 1997 Journal FEBS Lett. Section Title Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.30
For the multivariate model with log MTPM at 1 year using the same 4 factors, only PC1 of the knee adduction moment and BMI remained significant in the model (implant group: p = 0.1; BMI: p = 0.04; PC1 knee adduction moment: p = 0.09; PC1 knee flexion moment: p = 0.33).
Gene_expression (significant) of PC1 in knee
5) Confidence 0.49 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0 Pain Relevance 0
Higher PC1 scores were associated with higher flexion moment magnitudes during stance.
Gene_expression (scores) of PC1
6) Confidence 0.49 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0 Pain Relevance 0
In addition, proenkephalin was expressed only in the pheochromocytomas expressing PC2 and/or PC1/PC3.
Gene_expression (expressing) of PC1/PC3 associated with pheochromocytoma
7) Confidence 0.49 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8206338 Disease Relevance 0.34 Pain Relevance 0
Expressions of two Kex2-related proteases, Pc2 and PC1/PC3, and of one of their possible substrates, proenkephalin, were examined in normal (n = 7) and various pathological (n = 48) human adrenal tissues.
Spec (examined) Gene_expression (Expressions) of PC1/PC3
8) Confidence 0.49 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8206338 Disease Relevance 0.24 Pain Relevance 0
Expression of PC2 and PC1/PC3 in human pheochromocytomas.
Gene_expression (Expression) of PC1/PC3 associated with enkephalin and pheochromocytoma
9) Confidence 0.49 Published 1994 Journal Mol. Cell. Endocrinol. Section Title Doc Link 8206338 Disease Relevance 0.34 Pain Relevance 0.10
In the 20 pheochromocytomas studied with this technique, PC2, PC1/PC3 and proenkephalin were expressed in 85%, 50% and 90%, respectively.
Gene_expression (expressed) of PC1/PC3 associated with pheochromocytoma
10) Confidence 0.49 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8206338 Disease Relevance 0.35 Pain Relevance 0
Recombinant vaccinia virus vectors were used to coexpress mouse prohormone convertase 1 (mPC1), mPC2, or human furin together with human proenkephalin in GH4C1 cells (rat pituitary somatomammotrophs) to examine the proteolytic processing of proenkephalin by these enzymes.
Gene_expression (coexpress) of prohormone convertase 1 in pituitary associated with pox virus infection
11) Confidence 0.45 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8262946 Disease Relevance 0.10 Pain Relevance 0.11
PC-3 and T24 cells were successfully transfected in the bladder.
Gene_expression (transfected) of PC-3 in PC-3
12) Confidence 0.44 Published 2004 Journal J. Urol. Section Body Doc Link 15371873 Disease Relevance 0.06 Pain Relevance 0
In the 20 pheochromocytomas studied with this technique, PC2, PC1/PC3 and proenkephalin were expressed in 85%, 50% and 90%, respectively.
Gene_expression (expressed) of PC1/PC3 associated with pheochromocytoma
13) Confidence 0.42 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8206338 Disease Relevance 0.35 Pain Relevance 0
In addition, proenkephalin was expressed only in the pheochromocytomas expressing PC2 and/or PC1/PC3.
Gene_expression (expressing) of PC1/PC3 associated with pheochromocytoma
14) Confidence 0.42 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8206338 Disease Relevance 0.34 Pain Relevance 0
PC1 produced intermediate sized processing products (3-10 kDa); the major immunoreactive enkephalin-containing species observed eluted at the positions of peptide B, the 5.3-kDa fragment, and free Leu5-enkephalin.
Gene_expression (produced) of PC1 associated with enkephalin
15) Confidence 0.40 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8262946 Disease Relevance 0.08 Pain Relevance 0.61
Radiosequencing data verified that the production of the 5.3-kDa fragment by PC1 occurred as a result of a Lys-Lys cleavage.
Gene_expression (production) of PC1 in cleavage
16) Confidence 0.40 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8262946 Disease Relevance 0.05 Pain Relevance 0.67
The presence of PC2 and PC1/PC3 was further confirmed using the sensitive RT/PCR techniques.
Gene_expression (presence) of PC1/PC3
17) Confidence 0.38 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8206338 Disease Relevance 0.34 Pain Relevance 0
Among the prohormone convertases (PCs) tested, only PC2, its chaperone 7B2, and furin convertase but not PC1 and paired basic amino acid cleaving enzyme 4 gene were detected.
Gene_expression (detected) of PC1
18) Confidence 0.36 Published 2005 Journal Endocrinology Section Abstract Doc Link 16081629 Disease Relevance 0 Pain Relevance 0.13
Using a single component (PC1) it was possible to separate samples into two groups; one containing the three eEPC biological replicates with a high PC1 value, and other group with the three OEC biological replicates showing a low PC1 value (Figure 1D).
Gene_expression (value) of PC1
19) Confidence 0.26 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0
We also found that individual differences in metabolic activity in this overlapping amygdala region assessed during NEC or ALN were positively correlated with individual differences in the screening measures of anxious temperament that were determined 4.3 months prior to the FDG studies (early temperament vs. later NEC amygdala activity, r(33)?
Gene_expression (assessed) of NEC in amygdala associated with amygdala
20) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2430534 Disease Relevance 0.24 Pain Relevance 0.39

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