INT57643

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.51
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
blood 2
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 98.02 Very High Very High Very High
Clonidine 2 95.04 Very High Very High Very High
tolerance 3 94.80 High High
imagery 15 91.92 High High
carpal tunnel syndrome 1 17.76 Low Low
depression 2 16.44 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 68 99.56 Very High Very High Very High
Insulin Resistance 8 99.20 Very High Very High Very High
INFLAMMATION 12 98.02 Very High Very High Very High
Apoptosis 31 97.74 Very High Very High Very High
Stress 19 97.52 Very High Very High Very High
Impaired Glucose Tolerance 4 94.80 High High
Acid Base Imbalance 68 92.92 High High
Cv Unclassified Under Development 7 92.88 High High
Heart Rate Under Development 2 90.12 High High
Chronic Renal Failure 64 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On rechallenge with insulin and glucose, blood pressure again rose and then decreased after termination of the insulin and glucose administration.
Negative_regulation (decreased) of insulin Binding (rechallenge) of in blood
1) Confidence 0.43 Published 1994 Journal Hypertension Section Abstract Doc Link 8206584 Disease Relevance 0.18 Pain Relevance 0.15
The reduction of the initial glucose levels versus time after intragastric insulin-loaded SLN, insulin solution and subcutaneous administration of insulin is depicted in Figure 2.
Negative_regulation (reduction) of insulin-loaded Binding (intragastric) of
2) Confidence 0.41 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0.10 Pain Relevance 0.03
Electron microscopy pictures of cardiac tissue were also evaluated for signs of cardiac damage

Results:

                  Markers of oxidative stress, apoptosis, inflammation as well as manifestations of cardiac damage as assessed by electron microscopy were significantly decreased in rats treated with both insulin and vitamin E when compared with untreated diabetic rats or rats treated with either insulin or vitamin E alone

Conclusion:

Negative_regulation (decreased) of insulin Binding (treated) of associated with stress, inflammation, diabetes mellitus and apoptosis
3) Confidence 0.24 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Abstract Doc Link PMC2570581 Disease Relevance 1.32 Pain Relevance 0.05
-subunit (IR) measured by insulin receptor (?
Negative_regulation (measured) of insulin Binding (receptor) of
4) Confidence 0.07 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2262060 Disease Relevance 0 Pain Relevance 0
1 for 1 h followed by infusion with insulin and saline at 1.5 units ยท kg?
Negative_regulation (followed) of insulin Binding (infusion) of
5) Confidence 0.05 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 0.36 Pain Relevance 0.11
In vitro experiments revealed that the insulin resistance was attributed, in part, to pH-related impaired binding of insulin to its receptors [89, 90].
Negative_regulation (impaired) of insulin Binding (binding) of associated with insulin resistance
6) Confidence 0.02 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.55 Pain Relevance 0.08

General Comments

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