INT57645

Context Info Confidence 0.62 First Reported 1993 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 54 Total Number 56 Disease Relevance 21.05 Pain Relevance 4.20

peroxisome (GSTK1) intracellular (GSTK1)

Anatomy Link Frequency liver 4 urine 2 Plasma 1 aorta 1 Section 2 1 GSTK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 349 99.68 tolerance 82 99.40 Chronic pancreatitis 19 98.36 vincristine 3 96.80 Restless leg syndrome 1 90.48 sodium channel 3 89.40 Bile 10 88.48 imagery 7 83.44 Neuropathic pain 1 81.00 dorsal root ganglion 4 79.28

Disease Link Frequency Relevance Heat Obesity 38 99.96 Skin Cancer 10 99.86 Coronary Artery Disease 172 99.80 Pancreatic Cancer 80 99.68 Nicotine Addiction 250 99.52 Overdose 24 99.52 Atherosclerosis 42 99.44 Non-genital Cutaneous Warts 3 99.44 Cancer 508 98.88 Recurrence 18 98.74

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The glutathione transferase activity towards trans-stilbene oxide (GST-tSBO) can be separated in blood in GST-positive and GST-negative phenotypes.

Gene_expression (negative) of GST-negative in blood

1) Confidence 0.62 Published 1993 Journal Int Angiol Section Abstract Doc Link 8207312 Disease Relevance 0.18 Pain Relevance 0.09

As mentioned above, there are still some controversies about the relationship between GST polymorphism and CAD in smokers.

Gene_expression (polymorphism) of GST associated with nicotine addiction and coronary artery disease

2) Confidence 0.55 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.96 Pain Relevance 0

Epidemiological studies have indicated that GSTM1 and GSTT1 polymorphisms are associated with increased risk for different cancers among smokers, but there are still some controversies about the relationship between GST polymorphism and CAD in smokers (7, 17).

Gene_expression (polymorphism) of GST associated with coronary artery disease, nicotine addiction and cancer

3) Confidence 0.55 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.34 Pain Relevance 0

Levels of GST 5-5 were also induced in the islets.

Gene_expression (Levels) of GST

4) Confidence 0.50 Published 1993 Journal J. Pathol. Section Abstract Doc Link 8501544 Disease Relevance 0.79 Pain Relevance 0.39

Indeed, although mammalian GST ?

Gene_expression (although) of GST

5) Confidence 0.48 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.19 Pain Relevance 0

Why, then, do GST polymorphisms apparently have less impact on pharmacokinetics?

Gene_expression (polymorphisms) of GST

6) Confidence 0.43 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.07 Pain Relevance 0

(GST-GSH binding affinity is exploited in commercially available systems for expression of recombinant proteins as GST fusions, such as the pGEX vectors.)

Gene_expression (fusions) of GST

7) Confidence 0.43 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0 Pain Relevance 0.09

(GST-GSH binding affinity is exploited in commercially available systems for expression of recombinant proteins as GST fusions, such as the pGEX vectors.)

Gene_expression (exploited) of GST

8) Confidence 0.43 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.05 Pain Relevance 0.09

The human genome encodes at least 18 expressed GST enzymes, in the eight sequence-similarity classes listed in Section 2.2 [5, 51, 55, 56].

Gene_expression (expressed) of GST in Section 2

9) Confidence 0.38 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0 Pain Relevance 0

Fourth, genetic polymorphisms probably account for only a small proportion of the large interindividual variation in GST expression and activity [17–19].

Gene_expression (expression) of GST

10) Confidence 0.38 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.16 Pain Relevance 0.09

Human GST enzymes include members of eight classes, assigned on the basis of sequence similarity: Alpha, Mu, Pi, Theta, Kappa, Zeta, Omega, and Sigma.

Gene_expression (enzymes) of GST

11) Confidence 0.37 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.07 Pain Relevance 0.12

Human GST classes Alpha, Mu, Theta, and Omega all have multiple members, encoded by clusters of paralogous genes on a given chromosome (Figure 2).

Gene_expression (classes) of GST

12) Confidence 0.37 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0 Pain Relevance 0

These mice express lower basal levels of the Nrf2 target genes such as NQO1, GST, GCS, UDP-glucuronosyltransferase, glutathione peroxidase-2, and HO-1 (Chan and Kwong 2000; Cho et al. 2002; Hayes et al. 2000; Kwak et al. 2001; McMahon et al. 2001).

Gene_expression (express) of GST

13) Confidence 0.34 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.74 Pain Relevance 0.07

BED = biologically effective dose; BMI = body mass index; GST = glutathione S-transferase; PCR = polymerase chain reaction; ROS = reactive oxygen species.

Gene_expression (glutathione S-transferase) of GST in body associated with obesity

14) Confidence 0.32 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.91 Pain Relevance 0

There is an absence of data regarding this issue, although earlier work did show that prevention of breast cancer relapse with radiation therapy was greatest among women with elevated levels of GST ?

Gene_expression (levels) of GST associated with breast cancer and recurrence

15) Confidence 0.32 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.84 Pain Relevance 0

These mice express lower basal levels of the Nrf2 target genes such as NQO1, GST, GCS, UDP-glucuronosyltransferase, glutathione peroxidase-2, and HO-1 (Chan and Kwong 2000; Cho et al. 2002; Hayes et al. 2000; Kwak et al. 2001; McMahon et al. 2001).

Gene_expression (express) of GST

16) Confidence 0.29 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.74 Pain Relevance 0.07

In addition to GCS, which modulates intracellular glutathione levels, other Nrf2 downstream genes, including GST, UDP-glucuronosyl transferase, and multidrug resistance proteins, also contribute to the Nrf2-mediated protection against arsenic toxicity (Hayashi et al. 2003; Kobayashi and Yamamoto 2006; Maher et al. 2005; Vernhet et al. 2001; Xu et al. 2005; Zhang 2006).

Gene_expression (proteins) of GST associated with toxicity

17) Confidence 0.29 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.35 Pain Relevance 0

Because radiation results in generation of ROS and lipid peroxidation, the finding that nuclear GST ?

Gene_expression (nuclear) of GST

18) Confidence 0.28 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.78 Pain Relevance 0

Human UGT, SULT, NAT, and GST mRNA were expressed in the liver of the chimeric mice, and UGT2B7, SULT1E1, SULT2A1, and GSTA1 proteins could be detected.

Gene_expression (expressed) of GST mRNA in liver

19) Confidence 0.24 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15932951 Disease Relevance 0 Pain Relevance 0.07

The lack of treatment effects on gst expression in females may relate to their higher levels of endogenous estrogen that, in turn, are likely to account for the lower gst levels observed in females compared with males, and may render them less sensitive to induction/inhibition by exogenous chemicals.

Gene_expression (expression) of gst

20) Confidence 0.24 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.08 Pain Relevance 0.03

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