INT57673

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Context Info
Confidence 0.24
First Reported 1994
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.27
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
head 2
htr (Mus musculus)
Pain Link Frequency Relevance Heat
tramadol 7 100.00 Very High Very High Very High
antidepressant 5 100.00 Very High Very High Very High
fluoxetine 3 100.00 Very High Very High Very High
narcan 1 99.18 Very High Very High Very High
antagonist 4 98.98 Very High Very High Very High
opioid receptor 3 98.74 Very High Very High Very High
Morphine 1 95.60 Very High Very High Very High
Kappa opioid receptor 3 86.24 High High
Analgesic 1 82.08 Quite High
Opioid 1 81.68 Quite High
Disease Link Frequency Relevance Heat
Shock 2 100.00 Very High Very High Very High
Tourette's Syndrome 1 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To develop a mouse model to mimic the behavioral and neurochemical changes of Tourette syndrome (TS) by 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) induction and to investigate the effects of fluoxetine and haloperidol on head twitch response (HTR) induced by DOI.
Spec (investigate) Regulation (effects) of Positive_regulation (induced) of HTR in head associated with tourette's syndrome and fluoxetine
1) Confidence 0.24 Published 2007 Journal Zhongguo Dang Dai Er Ke Za Zhi Section Abstract Doc Link 17937861 Disease Relevance 0.10 Pain Relevance 0.17
The effect of chronic administration of antidepressants and electroconvulsive shock (ESC) on the hypothermic response (HTR) induced by 8-hydroxy-2-(di-n-propyramino) tetralin (8-OH-DPAT) as an index of the function of 5-HT1A receptors was investigated in the rat. 2. 8-OH-DPAT dose-dependently decreased the rectal temperature. 3.
Spec (investigated) Regulation (effect) of Spec (investigated) Positive_regulation (induced) of HTR associated with antidepressant and shock
2) Confidence 0.15 Published 1994 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 8208989 Disease Relevance 0.17 Pain Relevance 0.26
Furthermore, the nonselective opioid receptor antagonists, naloxone and diprenorphine (M5050), reversed the effect of tramadol on 5-HTP-induced HTR dose-dependently.
Regulation (effect) of Positive_regulation (induced) of HTR associated with tramadol, antagonist, narcan and opioid receptor
3) Confidence 0.14 Published 2003 Journal Life Sci. Section Abstract Doc Link 12570923 Disease Relevance 0 Pain Relevance 1.32

General Comments

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