INT57677

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Context Info
Confidence 0.23
First Reported 1994
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.53
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
liver 2
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 30 100.00 Very High Very High Very High
anesthesia 1 83.72 Quite High
Bile 1 76.56 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 3 99.28 Very High Very High Very High
Necrosis 1 76.44 Quite High
Nephrotoxicity 3 76.00 Quite High
Toxicity 1 75.00 Quite High
Targeted Disruption 1 60.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Castration also did not alter APAP covalent binding in liver or APAP hepatotoxicity.
Neg (not) Regulation (alter) of APAP Binding (binding) of in liver associated with paracetamol and hepatotoxicity
1) Confidence 0.23 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8209379 Disease Relevance 0.40 Pain Relevance 1.29
In conclusion, the data presented in this study define an RXRalpha-Gst regulatory network that controls APAP-GSH conjugation.
Regulation (controls) of APAP-GSH Binding (conjugation) of associated with paracetamol
2) Confidence 0.00 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16157696 Disease Relevance 0.13 Pain Relevance 0.88

General Comments

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