INT57691

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Context Info
Confidence 0.40
First Reported 1993
Last Reported 2010
Negated 5
Speculated 8
Reported most in Body
Documents 23
Total Number 31
Disease Relevance 17.08
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
A549 4
plasma 2
colon 2
lung 2
decidua 2
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 444 100.00 Very High Very High Very High
antagonist 66 100.00 Very High Very High Very High
ischemia 78 99.84 Very High Very High Very High
COX-2 inhibitor 31 99.48 Very High Very High Very High
cINOD 67 98.86 Very High Very High Very High
cytokine 63 98.32 Very High Very High Very High
Inflammatory response 24 96.48 Very High Very High Very High
Stimulus evoked pain 3 94.36 High High
Arthritis 48 93.36 High High
rheumatoid arthritis 23 91.04 High High
Disease Link Frequency Relevance Heat
Hemophilus Infection 712 100.00 Very High Very High Very High
INFLAMMATION 479 100.00 Very High Very High Very High
Infection 100 99.88 Very High Very High Very High
Cancer 260 99.84 Very High Very High Very High
Cv Unclassified Under Development 62 99.84 Very High Very High Very High
Granuloma 2 99.76 Very High Very High Very High
Bacterial Respiratory Disease 1 99.36 Very High Very High Very High
Bordatella Infection 1 98.92 Very High Very High Very High
Breast Cancer 60 98.72 Very High Very High Very High
Malignant Neoplastic Disease 52 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is important to regulate the production of PGE2 for the maintenance and successful accomplishment of function.
Regulation (regulate) of Gene_expression (production) of PGE2
1) Confidence 0.40 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.05 Pain Relevance 0.09
The results also suggest that the synthesis of PGE2 is regulated by autocrine and paracrine factors (i.e. cytokines) as a result of epithelial-stromal interactions.
Regulation (regulated) of Gene_expression (synthesis) of PGE2 associated with cytokine
2) Confidence 0.28 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.40 Pain Relevance 0.13
Introduction of the EP2 receptor had no effect on the expression profile of the other E-series receptors and of FP receptor which could be activated by prostanoid ligands in our study.
Neg (no) Regulation (effect) of Gene_expression (expression) of EP2
3) Confidence 0.25 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.07 Pain Relevance 0
Thus the regulation of PGE2 and IL-6 production from murine decidua by LPS and inflammatory cytokines is similar to findings previously reported for human decidua.
Regulation (regulation) of Gene_expression (production) of PGE2 in decidua associated with inflammation and cytokine
4) Confidence 0.13 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8418915 Disease Relevance 0.88 Pain Relevance 0.34
We carried out experiments to investigate whether the COX-2 inhibitor celecoxib at a dose of either 200 mg bid or 400 mg bid could significantly affect endogenous uPA, PAI-1 or PGE2 production in women at increased risk for breast cancer.
Regulation (affect) of Gene_expression (production) of PGE2 associated with breast cancer and cox-2 inhibitor
5) Confidence 0.13 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.17 Pain Relevance 0.05
The effects of three anti-inflammatory or immunosuppressive drugs, prednisolone, indomethacin and cyclosporin A, on IL-1 beta and PGE2 production in zymosan and Bordetella-pertussis-vaccine (BPV)-challenged tissue chambers were also examined.
Spec (examined) Regulation (effects) of Gene_expression (production) of PGE2 associated with bordatella infection, inflammation and bacterial respiratory disease
6) Confidence 0.12 Published 1993 Journal Agents Actions Section Abstract Doc Link 8213352 Disease Relevance 0.81 Pain Relevance 0.25
Thus, P2X4Rs are specifically involved in inflammatory-mediated PGE2 production and might therefore represent useful therapeutic targets.
Regulation (involved) of Gene_expression (production) of PGE2 in PGE2 associated with inflammation
7) Confidence 0.10 Published 2010 Journal EMBO J. Section Abstract Doc Link 20562826 Disease Relevance 1.11 Pain Relevance 0.78
Interestingly only the EP2 receptor antagonist, but not the EP4 receptor antagonist abolished the PGF2?
Neg (not) Regulation (only) of Gene_expression (antagonist) of EP2 receptor associated with antagonist
8) Confidence 0.10 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.19 Pain Relevance 0.23
We first evaluated the change in uPA, PAI-1 and PGE2 concentration in the NAF of each participant after low and high dose celecoxib administration (Table 2).
Regulation (change) of Gene_expression (concentration) of PGE2
9) Confidence 0.09 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0 Pain Relevance 0
Effect of PK and Omez on PGE2 level
Regulation (on) of Gene_expression (level) of PGE2
10) Confidence 0.08 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.07 Pain Relevance 0
We first showed that PGE2 levels were lower in BALFs in LPS stimulated cPLA2?
Regulation (lower) of Gene_expression (levels) of PGE2
11) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.06 Pain Relevance 0.06
In agreement with previous results there was no significant difference between basal PGE2 levels in the cPLA2?
Neg (no) Regulation (difference) of Gene_expression (levels) of PGE2
12) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.49 Pain Relevance 0.20
In contrast the levels of PGE2 were not changed by ischemia in the cPLA2?
Neg (not) Regulation (changed) of Gene_expression (levels) of PGE2 associated with ischemia
13) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.59 Pain Relevance 0.25
We sought to determine if uPA, PA inhibitor (PAI)-1 and prostaglandin (PG)E2 expression in nipple aspirate fluid (NAF) and uPA and PGE2 expression in plasma were altered by celecoxib dose and concentration in women at increased breast cancer risk.


Regulation (altered) of Gene_expression (expression) of PGE2 in plasma associated with breast cancer
14) Confidence 0.06 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2580770 Disease Relevance 0.44 Pain Relevance 0
The relative roles of these constitutive enzymes for basal PGE2 production are currently unclear.
Regulation (roles) of Gene_expression (production) of PGE2
15) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.16 Pain Relevance 0.08
However, upon injection with LPS, these animals show up-regulation of mPGES-1 in most tissues and markedly increased PGE2 production [9-11].
Regulation (regulation) of Gene_expression (production) of PGE2
16) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.46 Pain Relevance 0.20
Furthermore, it has not yet been determined if these enzymes can contribute to increased PGE2 production during inflammation.
Regulation (contribute) of Gene_expression (production) of PGE2 associated with inflammation
17) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.18 Pain Relevance 0.09
This led us to examine the pulmonary expression of COX-1 and COX-2, two major enzymes involved in PGE2 synthesis.
Spec (examine) Regulation (involved) of Gene_expression (synthesis) of PGE2
18) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.45 Pain Relevance 0.12
Because COX-2 is responsible for the increased PGE2 production in cancer, the inhibition of COX-2 activity is critical for colon cancer chemoprevention.
Regulation (responsible) of Gene_expression (production) of PGE2 in colon associated with cancer and colon cancer
19) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.84 Pain Relevance 0.50
Peripheral COX-2 induction and PGE2 production depends on caspase-1
Regulation (depends) of Gene_expression (production) of PGE2
20) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.35 Pain Relevance 0.17

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