INT57692

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 50
Total Number 51
Disease Relevance 43.54
Pain Relevance 28.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
frontal cortex 11
macrophage 6
blood 6
neutrophil 6
liver 4
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 126 100.00 Very High Very High Very High
cytokine 113 100.00 Very High Very High Very High
antagonist 22 100.00 Very High Very High Very High
Analgesic 18 100.00 Very High Very High Very High
Glutamate 18 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
Antinociceptive 12 100.00 Very High Very High Very High
chemokine 12 100.00 Very High Very High Very High
anakinra 12 100.00 Very High Very High Very High
Hippocampus 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 110 100.00 Very High Very High Very High
Urological Neuroanatomy 37 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Adhesions 16 100.00 Very High Very High Very High
Cancer 11 100.00 Very High Very High Very High
Nervous System Injury 80 99.92 Very High Very High Very High
Injury 18 99.82 Very High Very High Very High
Pressure And Volume Under Development 16 99.82 Very High Very High Very High
Leishmaniasis 7 99.64 Very High Very High Very High
Stress 69 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To examine the effects of intraarticular induction of interleukin-1beta (IL-1beta) expression in adult mice.
Spec (examine) Positive_regulation (induction) of Gene_expression (expression) of IL-1beta
1) Confidence 0.67 Published 2006 Journal Arthritis Rheum. Section Abstract Doc Link 16572453 Disease Relevance 0.15 Pain Relevance 0.15
Overexpression of spinal IL-1beta in the recently developed GFAP-IL-1betaXAT somatic mosaic model of neuroinflammation led to development of arthritis-like pathology accompanied by increased pain-like behavior.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IL-1beta in spinal
2) Confidence 0.67 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18821694 Disease Relevance 0.11 Pain Relevance 0
METHODS: Col1-IL-1betaXAT mice and GFAP-IL-1betaXAT mice were injected with the feline immunodeficiency virus (FIV) (Cre) vector in the right and left temporomandibular joints (TMJs), or in the cisterna magna, respectively, to induce IL-1beta expression in the dorsal horns of the spinal horn.
Positive_regulation (induce) of Gene_expression (expression) of IL-1beta in horn
3) Confidence 0.67 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18821694 Disease Relevance 0.18 Pain Relevance 0
Indeed, real time PCR analysis detected a CCI-induced upregulation of Tlr4 and Il1b expression in the lumbar region of wt but not Cckbr KO mice.
Positive_regulation (upregulation) of Gene_expression (expression) of Il1b in lumbar region associated with eae and lumbar region
4) Confidence 0.67 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18054398 Disease Relevance 0.70 Pain Relevance 0.66
A significantly increased expression of TNF-alpha and IL-1beta was observed in both strains.
Positive_regulation (increased) of Gene_expression (expression) of IL-1beta associated with sprains and strains
5) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.47 Pain Relevance 0.42
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Positive_regulation (induced) of Gene_expression (expression) of IL-1beta associated with paracetamol
6) Confidence 0.67 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
The anti-inflammatory mechanism of MKGS might be related to the lowering of MDA level in the edema paw via increasing the activities of superoxide dismutase (SOD) and GRx in the liver, as well as the decreases in the levels of TNF-alpha and NO, and the production of IL-1beta in inflamed tissues.
Positive_regulation (increasing) of Gene_expression (production) of IL-1beta in liver associated with pressure and volume under development and inflammation
7) Confidence 0.67 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503470 Disease Relevance 0.97 Pain Relevance 0.49
Socially isolated mice with nerve injury also were the only experimental group to exhibit increased frontal cortex IL-1beta gene expression on day 7 post injury.
Positive_regulation (increased) of Gene_expression (expression) of IL-1beta in frontal cortex
8) Confidence 0.67 Published 2010 Journal Psychosom Med Section Body Doc Link 20466999 Disease Relevance 0.07 Pain Relevance 0
RESULTS: The expression and concentration of IL-1 beta, IL-6, and IL-8 were increased with increasing concentration of 17beta-estradiol.
Positive_regulation (increased) of Gene_expression (expression) of IL-1 beta
9) Confidence 0.53 Published 2008 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 18423275 Disease Relevance 0.08 Pain Relevance 0
Moreover, SNI animals displayed increased interleukin-1beta (IL-1beta) gene expression within the frontal cortex and concurrent increases in the expression of glial fibrillary acidic protein (GFAP) within the periaqueductal grey (PAG).
Positive_regulation (increased) of Gene_expression (expression) of interleukin-1beta in frontal cortex associated with nervous system injury, periaqueductal grey and urological neuroanatomy
10) Confidence 0.49 Published 2010 Journal Mol. Psychiatry Section Abstract Doc Link 19773812 Disease Relevance 2.31 Pain Relevance 0.58
The pattern of chemokine expression is consistent with the delay in neutrophil recruitment to the footpad: T. maculosa venom stimulated an early production of IL-1beta, IL-6, and MCP-1, but was unable to induce an effective early TNF-alpha and KC release.
Neg (unable) Positive_regulation (stimulated) of Gene_expression (production) of IL-1beta in neutrophil associated with chemokine
11) Confidence 0.49 Published 2008 Journal Toxicon Section Abstract Doc Link 18586048 Disease Relevance 0.53 Pain Relevance 0.20
The pattern of chemokine expression is consistent with the delay in neutrophil recruitment to the footpad: T. maculosa venom stimulated an early production of IL-1beta, IL-6, and MCP-1, but was unable to induce an effective early TNF-alpha and KC release.
Positive_regulation (early) of Gene_expression (production) of IL-1beta in neutrophil associated with chemokine
12) Confidence 0.49 Published 2008 Journal Toxicon Section Abstract Doc Link 18586048 Disease Relevance 0.53 Pain Relevance 0.20
The anti-inflammatory mechanism of MKGS might be related to the lowering of MDA level in the edema paw via increasing the activities of superoxide dismutase (SOD) and GRx in the liver, as well as the decreases in the levels of TNF-alpha and NO, and the production of IL-1beta in inflamed tissues.
Positive_regulation (activities) of Gene_expression (production) of IL-1beta in liver associated with pressure and volume under development and inflammation
13) Confidence 0.49 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503470 Disease Relevance 0.96 Pain Relevance 0.49
Overexpression of spinal IL-1beta in the recently developed GFAP-IL-1betaXAT somatic mosaic model of neuroinflammation led to development of arthritis-like pathology accompanied by increased pain-like behavior.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IL-1beta in spinal
14) Confidence 0.49 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18821694 Disease Relevance 0.11 Pain Relevance 0
Antihyperalgesic effects induced by the IL-1 receptor antagonist anakinra and increased IL-1beta levels in inflamed and osteosarcoma-bearing mice.
Positive_regulation (increased) of Gene_expression (levels) of IL-1beta associated with anakinra, antihyperalgesic, antagonist and osteogenic sarcomas
15) Confidence 0.49 Published 2007 Journal Life Sci. Section Title Doc Link 17692876 Disease Relevance 1.25 Pain Relevance 1.07
In addition, i.p. treatment with SB225002 significantly attenuated the increase in MPO activity or the elevation of IL-1beta, TNFalpha or KC levels following carrageenan injection.
Positive_regulation (elevation) of Gene_expression (levels) of IL-1beta associated with chemokine and urological neuroanatomy
16) Confidence 0.49 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19264522 Disease Relevance 0.60 Pain Relevance 0.78
When inhibiting MAPKs using pharmacological inhibitors, we showed that p38MAPK inhibition abrogated the synergistic effect of APAP and LPS found for TNFalpha production but not for IL-1beta production.
Neg (not) Positive_regulation (for) of Gene_expression (production) of IL-1beta associated with paracetamol
17) Confidence 0.49 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.26 Pain Relevance 1.32
When LPS was added to APAP-treated cells, the increase in TNFalpha and IL-1beta production observed was higher than the sum of cytokine amounts produced with each agent alone, suggesting a synergistic mechanism.
Positive_regulation (increase) of Gene_expression (production) of IL-1beta associated with paracetamol and cytokine
18) Confidence 0.49 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.33 Pain Relevance 1.10
Cerulein treatment increased mRNA expression of several proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) at 12 h with similar magnitude both in wild-type and PACAP-Tg mice.
Positive_regulation (increased) of Gene_expression (expression) of IL-1beta associated with cytokine
19) Confidence 0.49 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.93 Pain Relevance 0.27
Moreover, SNI animals displayed increased interleukin-1beta (IL-1beta) gene expression within the frontal cortex and concurrent increases in the expression of glial fibrillary acidic protein (GFAP) within the periaqueductal grey (PAG).
Positive_regulation (increases) of Gene_expression (expression) of interleukin-1beta in frontal cortex associated with nervous system injury, periaqueductal grey and urological neuroanatomy
20) Confidence 0.49 Published 2010 Journal Mol. Psychiatry Section Abstract Doc Link 19773812 Disease Relevance 2.35 Pain Relevance 0.59

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