INT57699

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 8.49
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD1A) plasma membrane (CD1A)
Anatomy Link Frequency
histiocytes 3
CD86 1
accessory cells 1
Skin 1
legs 1
CD1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.84 Very High Very High Very High
Perioperative pain 1 96.88 Very High Very High Very High
analgesia 2 95.08 Very High Very High Very High
c fibre 1 94.92 High High
spinal-cord stimulation 14 93.48 High High
headache 5 93.12 High High
cytokine 9 93.00 High High
Inflammation 20 92.60 High High
epidural 6 92.16 High High
isoflurane 3 91.20 High High
Disease Link Frequency Relevance Heat
Adhesions 32 100.00 Very High Very High Very High
Langerhans-cell Histiocytosis 8 99.00 Very High Very High Very High
Cancer 31 98.98 Very High Very High Very High
Necrosis 4 98.12 Very High Very High Very High
Post Operative Pain 1 96.88 Very High Very High Very High
Juvenile Xanthogranuloma 3 95.36 Very High Very High Very High
Histiocytoma 3 94.72 High High
Dysarthria 1 93.72 High High
Headache 5 93.12 High High
INFLAMMATION 25 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both cases, the histiocytes were strongly positive for S-100 and CD1a, and Birbeck's granules were demonstrated by electron microscopy in the first case.
Positive_regulation (positive) of CD1a in histiocytes
1) Confidence 0.50 Published 2005 Journal Br J Neurosurg Section Abstract Doc Link 16120527 Disease Relevance 0.87 Pain Relevance 0.09
The orbital biopsy revealed tissue strongly positive for CD1a and S100, diagnostic of Langerhans cell histiocytosis.
Positive_regulation (positive) of CD1a in Langerhans cell associated with langerhans-cell histiocytosis
2) Confidence 0.46 Published 2009 Journal Ophthal Plast Reconstr Surg Section Abstract Doc Link 19300172 Disease Relevance 0.45 Pain Relevance 0.09
The initial dosage was determined (according to Bromage's method) to reach a sensory level of T-6.
Spec (determined) Positive_regulation (reach) of T-6
3) Confidence 0.45 Published 1993 Journal Anaesthesist Section Abstract Doc Link 8214533 Disease Relevance 0.10 Pain Relevance 0.65
After transection of the spinal cord at the T-6 level, there was a moderate threshold increase in both the early and late components in both legs, but the threshold of the early component in the nerve-ligated leg remained lower.
Positive_regulation (increase) of T-6 in legs associated with spinal cord
4) Confidence 0.45 Published 1996 Journal J. Neurosurg. Section Abstract Doc Link 8592227 Disease Relevance 0.06 Pain Relevance 0.66
By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein, CD68 and FXIIIa, but negative for CD1a.
Positive_regulation (negative) of CD1a in histiocytes
5) Confidence 0.21 Published 2005 Journal Zentralbl. Neurochir. Section Abstract Doc Link 16116557 Disease Relevance 0.98 Pain Relevance 0.16
The Langerhans' cells contained interdigitated nuclei, exhibiting rather clear nucleoplasm and cytoplasm; they were positive for S-100 protein, CD1a, and also CD4.
Positive_regulation (positive) of CD1a
6) Confidence 0.12 Published 2008 Journal Med Mol Morphol Section Abstract Doc Link 18807145 Disease Relevance 1.49 Pain Relevance 0.07
Histiocytes were immunoreactive for the macrophage marker CD68 and negative for S-100 and CD1a.
Positive_regulation (negative) of CD1a in Histiocytes
7) Confidence 0.12 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9630181 Disease Relevance 0.45 Pain Relevance 0.18
Circulating (c)E-selectin levels increased by 820%, von Willebrand factor-Ag (vWF), soluble thrombomodulin, circulating (c)P-selectin, circulating intercellular adhesion molecule-1 (cICAM-1), and circulating vascular cell adhesion molecule-1 (cVCAM-1) by a mean of 65 to 98% (p < 0.001 for all), but cL-selectin by only 15%.
Positive_regulation (circulating) of molecule-1 associated with adhesions
8) Confidence 0.11 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10051263 Disease Relevance 1.13 Pain Relevance 0.35
Circulating (c)E-selectin levels increased by 820%, von Willebrand factor-Ag (vWF), soluble thrombomodulin, circulating (c)P-selectin, circulating intercellular adhesion molecule-1 (cICAM-1), and circulating vascular cell adhesion molecule-1 (cVCAM-1) by a mean of 65 to 98% (p < 0.001 for all), but cL-selectin by only 15%.
Positive_regulation (circulating) of molecule-1 associated with adhesions
9) Confidence 0.11 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10051263 Disease Relevance 1.14 Pain Relevance 0.38
Skin biopsy of these lesions shows a characteristic vacuolated histiocytic infiltrate which contains Touton giant cells in 85% of the cases and a characteristic positivity of the lesions to factor XIIIa, CD68, CD163, fascin, and CD14 but negative S100 and CD1 on immunohistochemistry [10].
Positive_regulation (negative) of CD1 in Skin
10) Confidence 0.11 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.21 Pain Relevance 0.16
Zhang et al. [73] reported that MSCs inhibited the upregulation of CD1a, CD40, CD80, and CD86 during DC maturation.
Positive_regulation (upregulation) of CD1a in CD86
11) Confidence 0.07 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.17 Pain Relevance 0.13
Varying from the tumour cells, scattered accessory cells were found to be positive for smooth muscle actin, S100, CD1a and CD68.


Positive_regulation (positive) of CD1a in accessory cells associated with cancer
12) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2903530 Disease Relevance 0.45 Pain Relevance 0

General Comments

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