INT5770

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Context Info
Confidence 0.41
First Reported 1982
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 88
Total Number 91
Disease Relevance 13.23
Pain Relevance 55.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
brain 5
MVD 4
tail 3
neurons 3
ileum 2
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 322 100.00 Very High Very High Very High
Morphine 312 100.00 Very High Very High Very High
opioid receptor 155 100.00 Very High Very High Very High
Opioid 155 100.00 Very High Very High Very High
nMDA receptor 62 100.00 Very High Very High Very High
mu opioid receptor 39 100.00 Very High Very High Very High
GABA receptor 31 100.00 Very High Very High Very High
Dopamine 30 100.00 Very High Very High Very High
Delta opioid receptors 20 100.00 Very High Very High Very High
opiate 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 119 99.92 Very High Very High Very High
Cancer 28 99.84 Very High Very High Very High
Nociception 81 99.68 Very High Very High Very High
Tics 11 99.68 Very High Very High Very High
Necrosis 9 99.60 Very High Very High Very High
Coma 14 99.40 Very High Very High Very High
Brain Concussion 2 98.88 Very High Very High Very High
Pathologic Processes 3 98.64 Very High Very High Very High
Respiratory Failure 17 98.44 Very High Very High Very High
Targeted Disruption 426 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone (0.1 and 1 mg/kg s.c.) partially antagonized the effect of azepexole in the tail-immersion and tail-pinch tests but significantly decreased the slope of the dose-response curve suggesting that a competitive interaction at the level of the opioid receptors did not occur.
receptors Binding (interaction) of in tail associated with narcan and opioid receptor
1) Confidence 0.41 Published 1989 Journal Pain Section Abstract Doc Link 2919089 Disease Relevance 0 Pain Relevance 0.57
We suggest that U-50,488H suppresses the development of tolerance to morphine at the spinal level by interacting with kappa opioid receptors in this area.
receptors Binding (interacting) of in spinal associated with kappa opioid receptor, tolerance and morphine
2) Confidence 0.41 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1664330 Disease Relevance 0 Pain Relevance 1.43
4-Phenyl-1-(4-phenylbutyl)piperidine (4-PPBP) is a very potent ligand for sigma (Sigma) receptors.
receptors Binding (ligand) of
3) Confidence 0.40 Published 1995 Journal Synapse Section Abstract Doc Link 7624833 Disease Relevance 0 Pain Relevance 0.09
ICI 174864 (25 micrograms icv or 20 mg/kg s.c.) did not interact with mu opioid receptors in mice rendered physically dependent on morphine.
receptors Neg (not) Binding (interact) of associated with mu opioid receptor and morphine
4) Confidence 0.40 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2987731 Disease Relevance 0.14 Pain Relevance 0.53
S-135, 2-(5-methylthien-3-yl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinoline-3- one, bind binds to benzodiazepine receptors with a high affinity and shows pharmacological actions opposite to those of conventional benzodiazepine drugs. 2.
receptors Binding (bind) of
5) Confidence 0.40 Published 1988 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 2853884 Disease Relevance 0.21 Pain Relevance 0.11
A significant reduction in [3H]deltorphin-I binding to delta receptors and a significant increase in [3H]CI-977 binding to kappa receptors was detected in the spinal cords but not in the brains of the knock-out mice.
receptors Binding (binding) of in brains associated with targeted disruption
6) Confidence 0.35 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12417646 Disease Relevance 0.55 Pain Relevance 0.89
In vivo labeling of sigma receptors in mouse brain with [3H]4-phenyl-1-(4-phenylbutyl)piperidine.
receptors Binding (labeling) of in brain
7) Confidence 0.31 Published 1995 Journal Synapse Section Title Doc Link 7624833 Disease Relevance 0 Pain Relevance 0.16
These results indicate that: (as) the regional alterations in the affinity and distribution of GABA receptors may play a role in the induction, maintenance, and regression of morphine tolerance; (b) abrupt withdrawal and antagonist precipitated withdrawal affect the GABA system differently, (c) chronic morphine treatment appears to influence the GABA receptors in the cerebellum, a region generally known for its lack of opiate receptors.
receptors Neg (lack) Binding (lack) of in cerebellum associated with gaba, antagonist, gaba receptor, tolerance, opiate, withdrawal and morphine
8) Confidence 0.30 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6288864 Disease Relevance 0 Pain Relevance 1.15
The effects of morphine on the affinity and distribution of GABA receptors in the mouse regions (striatum, medulla, diencephalon, cortex, and cerebellum) were investigated in relation to: (a) acute administration, (b) chronic administration (tolerance), (c) precipitated withdrawal by naloxone, an opiate antagonist, and (d) abrupt withdrawal for 8 and 24 h.
receptors Binding (affinity) of in striatum associated with narcan, morphine, medulla, gaba receptor, antagonist, tolerance, opiate and withdrawal
9) Confidence 0.30 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6288864 Disease Relevance 0 Pain Relevance 0.66
S-135, 2-(5-methylthien-3-yl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinoline-3- one, bind binds to benzodiazepine receptors with a high affinity and shows pharmacological actions opposite to those of conventional benzodiazepine drugs. 2.
receptors Binding (binds) of
10) Confidence 0.30 Published 1988 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 2853884 Disease Relevance 0.21 Pain Relevance 0.11
A significant reduction in [3H]deltorphin-I binding to delta receptors and a significant increase in [3H]CI-977 binding to kappa receptors was detected in the spinal cords but not in the brains of the knock-out mice.
receptors Binding (binding) of in brains associated with targeted disruption
11) Confidence 0.26 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12417646 Disease Relevance 0.54 Pain Relevance 0.80
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
receptors Binding (binding) of associated with analgesic, antagonist, agonist, opioid receptor and opioid
12) Confidence 0.26 Published 2001 Journal Brain Res. Bull. Section Title Doc Link 11543951 Disease Relevance 0.08 Pain Relevance 1.07
Cocaine's ability to interact with sigma receptors suggests that these proteins mediate some of its behavioral effects.
receptors Binding (interact) of associated with cocaine
13) Confidence 0.18 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11426838 Disease Relevance 0 Pain Relevance 0.16
Additional studies revealed synergistic interactions between spinal kappa 1 and supraspinal kappa 3 receptors when nalbuphine was given both intrathecally and i.c.v.
receptors Binding (interactions) of in spinal associated with nalbuphine
14) Confidence 0.18 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1326621 Disease Relevance 0 Pain Relevance 1.92
The in vivo binding properties of cerebral opioid receptors were investigated in mice after intracerebroventricular (i.c.v.) injections of iodinated FK33-824 and [D.Ala2]deltorphin-I which behave in vitro as highly selective ligands possessing high affinity for mu and delta receptors, respectively. [125I]FK33-824 and [125I][D.Ala2] deltorphin-I exhibited similar diffusion kinetics after i.c.v. injection and bound specifically to sites characterized pharmacologically as mu and delta receptors respectively.
receptors Binding (bound) of associated with opioid receptor and intracerebroventricular
15) Confidence 0.14 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8247256 Disease Relevance 0 Pain Relevance 0.32
Opioid peptides modulate immune responses via ligation to classical opioid receptors (mu, delta and kappa), expressed on immune cells, or in an indirect fashion via the central nervous system.
receptors Binding (ligation) of in central nervous system associated with central nervous system, opioid receptor and opioid
16) Confidence 0.14 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15829417 Disease Relevance 0.25 Pain Relevance 0.31
Competition binding assays demonstrated that all three compounds have high affinities for sigma1 receptors.
receptors Binding (affinities) of
17) Confidence 0.14 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11426838 Disease Relevance 0.08 Pain Relevance 0.51
The three compounds vary in their affinities for sigma2 receptors and exhibit negligible affinities for dopamine, opioid, GABA(A) and NMDA receptors.
receptors Binding (affinities) of associated with gaba, dopamine, nmda receptor and opioid
18) Confidence 0.14 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11426838 Disease Relevance 0.13 Pain Relevance 0.54
The three compounds vary in their affinities for sigma2 receptors and exhibit negligible affinities for dopamine, opioid, GABA(A) and NMDA receptors.
receptors Binding (affinities) of associated with gaba, dopamine, nmda receptor and opioid
19) Confidence 0.14 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11426838 Disease Relevance 0.15 Pain Relevance 0.59
Etorphine, which has almost equal affinity for mu, delta and, incidentally, kappa receptors, showed a strong correlation between analgesia and respiratory depression.
receptors Binding (affinity) of in respiratory associated with depression, respiratory failure, analgesia and immobilon
20) Confidence 0.14 Published 1991 Journal Br J Anaesth Section Abstract Doc Link 1684279 Disease Relevance 0.43 Pain Relevance 1.34

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