INT5771

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 2.60
Pain Relevance 27.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
GPI 1
smooth muscle 1
brain 1
vas deferens 1
F11 1
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 147 100.00 Very High Very High Very High
Opioid 69 100.00 Very High Very High Very High
agonist 62 100.00 Very High Very High Very High
Enkephalin 53 100.00 Very High Very High Very High
antinociception 21 100.00 Very High Very High Very High
narcan 19 100.00 Very High Very High Very High
Delta opioid receptors 16 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
antagonist 57 99.98 Very High Very High Very High
Antinociceptive 23 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tics 15 99.44 Very High Very High Very High
Targeted Disruption 6 99.20 Very High Very High Very High
Pain 7 97.88 Very High Very High Very High
Urological Neuroanatomy 4 90.96 High High
Ganglion Cysts 3 85.96 High High
Neuroblastoma 3 83.44 Quite High
Nociception 2 77.16 Quite High
Drug Dependence 1 54.60 Quite High
Bordatella Infection 1 46.72 Quite Low
Shock 1 25.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The probe is a potent delta-antagonist in the mouse vas deferens (MVD) smooth muscle assay and it binds to the delta opioid receptor with high affinity (Ki = 1 nM) and selectivity.
delta opioid receptor Binding (binds) of in smooth muscle associated with antagonist and opioid receptor
1) Confidence 0.48 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9682822 Disease Relevance 0 Pain Relevance 0.42
The findings do not support the hypothesis that such agents bind to dimeric delta-opioid receptors.
delta-opioid Binding (bind) of associated with delta opioid receptors
2) Confidence 0.42 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 3123936 Disease Relevance 0 Pain Relevance 0.30
These results provide further evidence for the existence of delta opioid receptor subtypes where DADLE and DPDPE interact with one site and DSLET with a different one.
delta opioid receptor Binding (interact) of associated with opioid receptor
3) Confidence 0.40 Published 1991 Journal Life Sci. Section Abstract Doc Link 1658509 Disease Relevance 0 Pain Relevance 0.61
The thermodynamic quantities determined in this study in vivo (delta G zero' = -10.59 kcal mol-1, delta H zero' = -15.73 kcal mol-1 and delta S zero' = -0.0168 kcal mol-1 zero K-1) are consistent with data reported from radioligand binding studies in vitro and suggest that the interaction between naloxone and the opioid delta receptor in the mouse isolated vas deferens is enthalpy driven.
opioid delta receptor Binding (interaction) of in vas deferens associated with narcan and opioid
4) Confidence 0.39 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1335052 Disease Relevance 0 Pain Relevance 0.58
To investigate mechanisms by which agonists and antagonists interact with the delta opioid receptor, we have substituted aspartic acid 95 in the transmembrane segment 2 of the cloned mouse delta opioid receptor with an asparagine (D95N).
delta opioid receptor Binding (interact) of associated with antagonist, agonist and opioid receptor
5) Confidence 0.37 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8226821 Disease Relevance 0.09 Pain Relevance 0.97
The identification of a key residue involved in selective agonist binding to the delta opioid receptor will facilitate the development of novel therapeutic reagents that can be used for the treatment of chronic pain and other conditions.
delta opioid receptor Binding (binding) of associated with lasting pain, agonist and opioid receptor
6) Confidence 0.37 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8226821 Disease Relevance 0.10 Pain Relevance 0.96
In this issue of Cell, report that trafficking of the delta-opioid receptor to these vesicles depends on its physical interaction with the substance P domain of its precursor polyprotein (protachykinin).
delta-opioid receptor Binding (trafficking) of in vesicles associated with opioid receptor and substance p
7) Confidence 0.37 Published 2005 Journal Cell Section Abstract Doc Link 16122418 Disease Relevance 0.18 Pain Relevance 0.54
Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment.
delta opioid antinociception and receptor mRNA Binding (Assessment) of associated with pain, antinociception and opioid
8) Confidence 0.37 Published 1995 Journal Brain Res. Section Title Doc Link 8590066 Disease Relevance 0 Pain Relevance 0.88
Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment.
delta opioid antinociception and receptor mRNA Binding (Assessment) of associated with pain, antinociception and opioid
9) Confidence 0.37 Published 1995 Journal Brain Res. Section Title Doc Link 8590066 Disease Relevance 0 Pain Relevance 0.88
Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the delta opioid receptor (DOR-1).
delta opioid receptor Binding (targeting) of associated with analgesic, opioid receptor and morphine
10) Confidence 0.37 Published 1997 Journal Life Sci. Section Title Doc Link 9048971 Disease Relevance 0.08 Pain Relevance 0.98
Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the delta opioid receptor (DOR-1).
DOR-1 Binding (targeting) of associated with analgesic, opioid receptor and morphine
11) Confidence 0.37 Published 1997 Journal Life Sci. Section Title Doc Link 9048971 Disease Relevance 0.08 Pain Relevance 0.98
On the other hand, in mu 1-opioid receptor deficient CXBK mice, pretreatment with these selective delta-opioid receptor antagonists did not affect the morphine-induced place preference, although pretreatment with beta-funaltrexamine (beta-FNA: a selective mu-opioid receptor antagonist) significantly inhibited the morphine-induced place preference.
delta-opioid receptor Binding (pretreatment) of associated with antagonist, opioid receptor and morphine
12) Confidence 0.35 Published 1994 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7861658 Disease Relevance 0 Pain Relevance 1.51
These results are both consistent with previous reports that antisense oligodeoxynucleotide (ODN) treatment down-regulates DOR protein in vivo and indicate that this down-regulation is not associated with altered DOR mRNA levels.
DOR mRNA Binding (associated) of associated with opioid receptor
13) Confidence 0.35 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9379841 Disease Relevance 0.32 Pain Relevance 0.87
This requirement may reflect the binding of MDAN-19 and -21 to mu-opioid receptor-delta-opioid receptor heterodimeric receptors that block reward but not antinociception.
mu-opioid receptor-delta-opioid receptor Binding (binding) of associated with antinociception and opioid receptor
14) Confidence 0.32 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17383633 Disease Relevance 0.05 Pain Relevance 1.29
Under these conditions, repeated s.c. injection of (-)U-50,488H significantly enhanced both mu- and delta-opioid receptor agonist-stimulated [35S]GTPgammaS binding in the membrane of the thalamus.
delta-opioid receptor Binding (binding) of in thalamus associated with agonist, thalamus and opioid receptor
15) Confidence 0.31 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975677 Disease Relevance 0 Pain Relevance 1.36
Kinetic studies of binding of the delta-opioid antagonist [3H]DPN with receptors of mouse splenocytes are performed.
delta-opioid Binding (binding) of associated with antagonist and opioid
16) Confidence 0.31 Published 1999 Journal Biophys. Chem. Section Abstract Doc Link 10028232 Disease Relevance 0 Pain Relevance 0.35
The values of KA tended to increase (approximately doubled) over this temperature range, indicating that the affinity of DPDPE for the opioid delta receptor is an inverse function of temperature.
opioid delta receptor Binding (affinity) of associated with opioid
17) Confidence 0.31 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8384567 Disease Relevance 0 Pain Relevance 0.32
It is concluded that [3H]NTI binds to delta opioid receptor affinity states and subtypes with equal affinity and can be used for their characterization in conjunction with different treatment conditions and ligands.
delta opioid receptor Binding (binds) of associated with opioid receptor
18) Confidence 0.29 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113996 Disease Relevance 0 Pain Relevance 0.27
The values of KB tended to increase with temperature over the range examined, indicating that the affinity of naloxone for the opioid delta receptor is an inverse function of temperature.
opioid delta receptor Binding (affinity) of associated with narcan and opioid
19) Confidence 0.29 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1335052 Disease Relevance 0 Pain Relevance 0.43
It is not known, however, if a subtype of opioid delta receptor can be associated with the known modulatory action of delta agonists on mu-mediated antinociception.
opioid delta Binding (associated) of associated with antinociception, agonist and opioid
20) Confidence 0.19 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1328602 Disease Relevance 0 Pain Relevance 1.13

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