INT57719

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.95
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
plasma 1
SH-SY5Y 1
muscle tissue 1
muscles 1
GPM6A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 71 100.00 Very High Very High Very High
noradrenaline 3 99.98 Very High Very High Very High
narcan 9 99.66 Very High Very High Very High
opiate 9 98.52 Very High Very High Very High
Bioavailability 1 98.20 Very High Very High Very High
opioid receptor 2 89.20 High High
Opioid receptor 1 6 88.88 High High
Analgesic 4 82.40 Quite High
Pain 2 75.00 Quite High
Opioid 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 97.64 Very High Very High Very High
Cirrhosis 110 95.44 Very High Very High Very High
Pain 1 75.00 Quite High
Helminth Infection 2 74.76 Quite High
Hyperalgesia 1 25.00 Low Low
Neuropathic Pain 1 25.00 Low Low
Myoclonus 1 25.00 Low Low
Disease 7 23.12 Low Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Fibrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M3G and M6G are formed by morphine glucuronidation, mainly in the liver, and are excreted by the kidneys.
Localization (excreted) of M6G in liver associated with morphine
1) Confidence 0.44 Published 2003 Journal J Pain Symptom Manage Section Abstract Doc Link 12565191 Disease Relevance 0.07 Pain Relevance 1.15
Clearance of morphine to form M3G and M6G comprised 57.3% and 10.4%, respectively, and renal clearance comprised 10.9% of total systemic plasma clearance; hence, more than one-fifth of a dose (20.8%) remained as unidentified residual clearance.
Localization (form) of M6G in plasma associated with morphine
2) Confidence 0.19 Published 1993 Journal Clin Pharmacokinet Section Abstract Doc Link 8491060 Disease Relevance 0 Pain Relevance 0.92
However, naloxone could not block M6G stimulated NO release by muscle tissue, whereas CTOP (10(-7) M) blocked its release.
Neg (NO) Localization (release) of M6G in muscle tissue associated with narcan
3) Confidence 0.13 Published 2004 Journal Acta. Biol. Hung. Section Abstract Doc Link 15270252 Disease Relevance 0.07 Pain Relevance 1.21
We have examined the opiate binding characteristics, effects on cAMP formation and [3H]noradrenaline release of morphine, morphine-6 (M6G) and -3 (M3G)-glucuronides, and fentanyl in SH-SY5Y human neuroblastoma cells.
Localization (release) of M6G in SH-SY5Y associated with neuroblastoma, noradrenaline, opiate and morphine
4) Confidence 0.10 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8216364 Disease Relevance 0.10 Pain Relevance 0.87
Nitric oxide (NO) release in various tissues in response to morphine and its metabolite morphine-6-glucuronide (M6G) were also examined.
Spec (examined) Localization (release) of M6G associated with morphine
5) Confidence 0.03 Published 2004 Journal J. Parasitol. Section Abstract Doc Link 15040662 Disease Relevance 0 Pain Relevance 0.76
However, naloxone could not block M6G-stimulated NO release by muscles, whereas CTOP (10(-7) M) blocked its release.
Neg (NO) Localization (release) of M6G in muscles associated with narcan
6) Confidence 0.03 Published 2004 Journal J. Parasitol. Section Abstract Doc Link 15040662 Disease Relevance 0 Pain Relevance 1.04
Of the M3G and M6G formed during a single passage, 19 +/- 11% and 9 +/- 9%, respectively, was excreted into bile; the values were significantly different (P = 0.002).
Localization (excreted) of M6G in bile
7) Confidence 0.03 Published 1997 Journal Pharm. Res. Section Body Doc Link 9279882 Disease Relevance 0 Pain Relevance 0
Fig. 4Immunohistochemical localization of 15dPGJ2-M6PHSA (a) and 15dPGJ2-pPBHSA (b) in liver of BDL-10d rats, 15 min after intravenous injection of the constructs.
Localization (localization) of M6PHSA in liver
8) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.70 Pain Relevance 0.03

General Comments

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