INT57721

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Context Info
Confidence 0.16
First Reported 1993
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.12
Pain Relevance 5.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CCT6A) protein folding (CCT6A) cytosol (CCT6A)
cytoplasm (CCT6A)
Anatomy Link Frequency
SH-SY5Y 1
CCT6A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 147 100.00 Very High Very High Very High
Oxycodone 30 100.00 Very High Very High Very High
noradrenaline 3 99.98 Very High Very High Very High
Central nervous system 21 99.92 Very High Very High Very High
Opioid 222 99.70 Very High Very High Very High
Cancer pain 132 98.64 Very High Very High Very High
tricyclic antidepressant 30 98.56 Very High Very High Very High
opiate 29 98.52 Very High Very High Very High
carbamazepine 12 98.36 Very High Very High Very High
Analgesic 132 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 12 99.20 Very High Very High Very High
Cancer Pain 159 98.64 Very High Very High Very High
Epilepsy 3 97.96 Very High Very High Very High
Neuroblastoma 1 97.44 Very High Very High Very High
Renal Insufficiency 12 97.24 Very High Very High Very High
Myoclonus 6 95.20 Very High Very High Very High
Cirrhosis 3 91.68 High High
Intractable Pain 12 91.36 High High
Frailty 6 84.76 Quite High
Disease 27 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine and its metabolites are excreted by the kidneys and toxicity can be seen in patients with underlying renal insufficiency or failure.
Localization (excreted) of Morphine associated with toxicity, renal insufficiency and morphine
1) Confidence 0.16 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.94 Pain Relevance 1.45
Surgery is rarely used for the treatment of cancer pain these days, particularly since longer-acting opioids, such as slow-release oxycodone or morphine, and transcutaneous fentanyl patches became available.
Localization (release) of morphine associated with oxycodone, cancer pain, opioid and morphine
2) Confidence 0.16 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 1.34 Pain Relevance 1.58
The anti-epileptic drugs carbamazepine, phenobarbital, and phenytoin, as well as the antibiotic rifampin can accelerate clearance of morphine.
Localization (clearance) of morphine associated with epilepsy, morphine and carbamazepine
3) Confidence 0.15 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.74 Pain Relevance 1.28
We have examined the opiate binding characteristics, effects on cAMP formation and [3H]noradrenaline release of morphine, morphine-6 (M6G) and -3 (M3G)-glucuronides, and fentanyl in SH-SY5Y human neuroblastoma cells.
Localization (release) of morphine-6 in SH-SY5Y associated with neuroblastoma, noradrenaline, opiate and morphine
4) Confidence 0.03 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8216364 Disease Relevance 0.10 Pain Relevance 0.87
Nitric oxide (NO) release in various tissues in response to morphine and its metabolite morphine-6-glucuronide (M6G) were also examined.
Spec (examined) Localization (release) of morphine-6-glucuronide associated with morphine
5) Confidence 0.00 Published 2004 Journal J. Parasitol. Section Abstract Doc Link 15040662 Disease Relevance 0 Pain Relevance 0.71

General Comments

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