INT57724

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.81
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cux1) nucleus (Cux1) protein binding, bridging (Cux1)
DNA binding (Cux1) cytoplasm (Cux1)
Anatomy Link Frequency
blood 1
intermediary 1
Cux1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 415 100.00 Very High Very High Very High
Intracerebroventricular 3 99.84 Very High Very High Very High
agonist 56 99.66 Very High Very High Very High
Morphine 5 99.32 Very High Very High Very High
monoamine 65 99.30 Very High Very High Very High
Antinociceptive 1 98.00 Very High Very High Very High
fluoxetine 55 93.96 High High
sSRI 40 93.52 High High
tail-flick 15 89.64 High High
nociceptor 15 88.24 High High
Disease Link Frequency Relevance Heat
Arrhythmias 2 Under Development 5 96.12 Very High Very High Very High
Heart Rate Under Development 5 95.96 Very High Very High Very High
Pressure And Volume Under Development 2 95.68 Very High Very High Very High
Stress 5 87.96 High High
Death 2 84.96 Quite High
Coronary Artery Disease 3 82.72 Quite High
Depression 95 82.60 Quite High
Anxiety Disorder 7 77.64 Quite High
Respiratory Failure 3 75.00 Quite High
Reperfusion Injury 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither of these pretreatments except mecamylamine affected the pressor effect of CDP-choline.
Regulation (affected) of CDP-choline
1) Confidence 0.39 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18504556 Disease Relevance 1.07 Pain Relevance 0.19
The effects of cytidine diphosphate choline (CDP-choline, CAS 987-78-0) on learning and memory in rats with memory deficits were examined using behavioral methods of active avoidance with punishment reinforcement (shuttle-box), passive avoidance with punishment reinforcement (step-through and step-down), and active avoidance with positive (alimentary) reinforcement (staircase-maze).
Spec (examined) Regulation (effects) of CDP-choline
2) Confidence 0.38 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8216435 Disease Relevance 0 Pain Relevance 0
Indeed, considering the relatively marked effects of phenelzine and hydralazine, it is possible that inhibition of MAO-mediated monoamine breakdown may not be the predominant mechanism by which these compounds modulate CDP-DG signaling.
Regulation (modulate) of CDP associated with monoamine
3) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.29
Lithium is not required for antidepressant drug effects on CDP-diacylglycerol
Regulation (effects) of CDP associated with antidepressant
4) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.48
How then might an effect of antidepressant agents on CDP-DG and PI synthesis be associated with the antidepressive efficacy of the compounds?
Regulation (effect) of CDP associated with antidepressant
5) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.38
Monoamine receptor agonists exert divergent effects on CDP-diacylglycerol
Regulation (effects) of CDP associated with agonist and monoamine
6) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.51
But, is the presence of Li+ necessary to demonstrate antidepressant drug effects on CDP-DG?
Regulation (effects) of CDP associated with antidepressant
7) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.55
CDP pretreatment differentially affected the various blood gas parameters.
Regulation (affected) of CDP in blood
8) Confidence 0.26 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9512069 Disease Relevance 0.45 Pain Relevance 1.13
Note that, the permissive state of the CDP is basically stochastic in nature and influenced by many factors, such as behavioral conditioning circumstances.
Regulation (influenced) of CDP
9) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518957 Disease Relevance 0.14 Pain Relevance 0.29
The analysis of choline-containing metabolites showed that COX-2 inhibition affected the formation of CDP-choline intermediary.
Regulation (affected) of CDP-choline in intermediary
10) Confidence 0.02 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14698037 Disease Relevance 0 Pain Relevance 0.03
The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition.
Regulation (affected) of CDP-choline
11) Confidence 0.02 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14698037 Disease Relevance 0 Pain Relevance 0.07

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