INT57728

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Context Info
Confidence 0.41
First Reported 1993
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 25
Total Number 29
Disease Relevance 13.18
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (LDLR) small molecule metabolic process (LDLR) plasma membrane (LDLR)
lipid metabolic process (LDLR) lysosome (LDLR)
Anatomy Link Frequency
blood 4
plasma 2
macrophages 1
coronary artery 1
superior 1
LDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 32 99.98 Very High Very High Very High
Bile 68 99.28 Very High Very High Very High
addiction 1 97.32 Very High Very High Very High
rheumatoid arthritis 59 93.64 High High
Restless leg syndrome 8 93.28 High High
antagonist 5 92.84 High High
Osteoarthritis 8 91.72 High High
Paracetamol 4 90.56 High High
aspirin 14 88.64 High High
Inflammation 65 87.84 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 468 100.00 Very High Very High Very High
Coronary Artery Disease 185 99.66 Very High Very High Very High
Arteriosclerosis Obliterans 8 99.44 Very High Very High Very High
Insulin Resistance 17 98.88 Very High Very High Very High
Diabetes Mellitus 96 98.84 Very High Very High Very High
Hyperlipidemia 97 98.72 Very High Very High Very High
Atherosclerosis 130 98.40 Very High Very High Very High
Hypertension 18 97.96 Very High Very High Very High
Hyperlipoproteinemia Type Ii 12 96.60 Very High Very High Very High
Nicotine Addiction 69 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possibility is that NSAIDs affect low density lipoprotein (LDL) catabolism.
Regulation (affect) of low density lipoprotein associated with cinod
1) Confidence 0.41 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10395027 Disease Relevance 0.35 Pain Relevance 0.59
In this study we examined the effect of phenolic and non-phenolic active principles of common spices on copper ion-induced lipid peroxidation of human low density lipoprotein (LDL) by measuring the formation of thiobarbituric acid reactive substance (TBARS) and relative electrophoretic mobility (REM) of LDL on agarose gel.
Spec (examined) Regulation (effect) of low density lipoprotein
2) Confidence 0.40 Published 2002 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11936843 Disease Relevance 0 Pain Relevance 0.16
Circulating oxidized low density lipoprotein, autoantibodies against them and homocysteine serum levels in diagnosis and estimation of severity of coronary artery disease.
Regulation (Circulating) of low density lipoprotein in coronary artery associated with coronary artery disease
3) Confidence 0.36 Published 2005 Journal Free Radic. Res. Section Title Doc Link 16028367 Disease Relevance 0.80 Pain Relevance 0.32
Low-density lipoprotein (LDL) apheresis using an extracorporeal adsorption column containing dextran sulfate cellulose beads was applied to control lipid levels intensively in ASO patients with accompanying drug-resistant hyperlipidemia.
Regulation (control) of Low-density lipoprotein associated with arteriosclerosis obliterans and hyperlipidemia
4) Confidence 0.33 Published 1996 Journal Artif Organs Section Abstract Doc Link 9139617 Disease Relevance 0.47 Pain Relevance 0.08
The changes in LDL concentration and thus LDL-cholesterol are probably secondary phenomena.
Regulation (changes) of LDL-cholesterol
5) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.33 Pain Relevance 0
We found that both indomethacin and fluvastatin had an additive up-regulatory effect on LDL receptor activity.
Regulation (effect) of LDL receptor
6) Confidence 0.24 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10395027 Disease Relevance 0.13 Pain Relevance 0.47
We used liver and mononuclear cells that were available from guinea pigs treated with rapamycin where no effects were seen on plasma LDL cholesterol.
Neg (no) Regulation (effects) of LDL cholesterol in plasma
7) Confidence 0.24 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.08 Pain Relevance 0
For example, under increased dietary cholesterol challenge, the LDL receptor, responsible for the uptake of LDL-C is downregulated [1].
Regulation (responsible) of LDL receptor associated with disorder of lipid metabolism
8) Confidence 0.24 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.19 Pain Relevance 0.08
Efficacy of low-density lipoprotein apheresis in arteriosclerosis obliterans of the lower extremities: two cases with marked alleviation of clinical symptoms.
Regulation (Efficacy) of low-density lipoprotein associated with arteriosclerosis obliterans
9) Confidence 0.22 Published 2007 Journal J Clin Apher Section Title Doc Link 17610290 Disease Relevance 0.66 Pain Relevance 0.25
Analyses from that study showed that the effect of gemfibrozil treatment on HDL-cholesterol predicted a significant reduction in CHD, independent of changes in LDL-cholesterol and triglyceride levels.
Regulation (changes) of LDL-cholesterol associated with coronary artery disease and disorder of lipid metabolism
10) Confidence 0.19 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.68 Pain Relevance 0
Since the route of uptake of LDL by macrophages is profoundly changed after oxidation from the regulated LDLr to the unregulated scavenger receptors [16], it is important to establish whether the oxidative state also alters the mechanisms of uptake of CMR by the cells.
Regulation (regulated) of LDLr in macrophages
11) Confidence 0.18 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC1906864 Disease Relevance 0.05 Pain Relevance 0
The dependence of the plasma Lp-PLA2 levels from the LDL-cholesterol levels could also explain our results showing that therapy with DMARDs did not affect either the plasma LDL-cholesterol levels or the plasma Lp-PLA2 activity.
Neg (not) Regulation (affect) of LDL-cholesterol in plasma associated with addiction
12) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 0.69 Pain Relevance 0.29
Current status and future directions in lipid management: emphasizing low-density lipoproteins, high-density lipoproteins, and triglycerides as targets for therapy

Current lipid management guidelines are focused on decreasing low-density lipoprotein (LDL-C) levels as the primary target for reducing coronary heart disease (CHD) risk.

Regulation (target) of low-density lipoprotein in heart associated with coronary artery disease
13) Confidence 0.13 Published 2010 Journal Vascular Health and Risk Management Section Title Doc Link PMC2835557 Disease Relevance 1.04 Pain Relevance 0
The value of oxidized low-density lipoprotein (oxLDL) as a predictor of atherothrombotic complications has also been investigated.
Spec (investigated) Regulation (value) of low-density lipoprotein
14) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.99 Pain Relevance 0.11
To study the roles of modified low-density lipoprotein (LDL) and the molecular size of LDL in atherogenesis, the following studies were carried out.
Regulation (roles) of low-density lipoprotein associated with atherosclerosis
15) Confidence 0.13 Published 1993 Journal Pathobiology Section Abstract Doc Link 8216842 Disease Relevance 0.29 Pain Relevance 0.06
In addition, it modulates the effects of other factors such as high density lipoprotein (HDL)-cholesterol (Tonstad and Svendsen 2005), low density lipoprotein (LDL) (Xu et al 1994), and insulin resistance (Tonstad and Svendsen 2005).
Regulation (effects) of low density lipoprotein associated with insulin resistance and disorder of lipid metabolism
16) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515430 Disease Relevance 0.81 Pain Relevance 0
Because both the biliary excretion of cholesterol and the generation of bile acids from hepatic cholesterol may affect hepatic LDL receptor activity, these metabolic processes are integral for maintaining cholesterol homeostasis.
Spec (may) Regulation (affect) of LDL receptor in bile associated with bile
17) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.16 Pain Relevance 0.56
Furthermore, these guidelines have recently been extended and clarified to include the diabetic patient and the elderly patient, as well as lowering the targets for low-density lipoprotein (LDL) for high risk and very high risk patients (Grundy et al 2004).
Regulation (targets) of low-density lipoprotein associated with diabetes mellitus
18) Confidence 0.06 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994009 Disease Relevance 0.53 Pain Relevance 0.05
Serum TG levels decreased by 15.9% in 64 patients with basal TG levels of 150 mg/dL or more, and the serum HDL-C levels significantly increased.67 The effects of pitavastatin 2 mg on the serum RLP-C and small, dense LDL-cholesterol levels were compared with those of atorvastatin 10 mg in heterozygous patients with familial hypercholesterolemia.
Regulation (effects) of LDL-cholesterol associated with hyperlipoproteinemia type ii and disorder of lipid metabolism
19) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.55 Pain Relevance 0
A complete fasting lipid panel was obtained from blood samples at baseline and at weeks 4, 8, 12, 20, and 28 to allow measurement of the primary study endpoint (change from baseline in fasting serum total cholesterol) and secondary study endpoints (change from baseline in LDL-cholesterol, very low density lipoprotein (VLDL)-cholesterol, high density lipoprotein (HDL)-cholesterol, and triglycerides).
Regulation (change) of LDL-cholesterol in blood associated with disorder of lipid metabolism
20) Confidence 0.04 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC548524 Disease Relevance 0.61 Pain Relevance 0

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