INT57734

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Context Info
Confidence 0.48
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 36
Total Number 38
Disease Relevance 11.94
Pain Relevance 15.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
hair 4
TM1 1
MEG-01 1
midbrain 1
SLC6A4 (Homo sapiens)
SLC6A4 - N208Q (1) SLC6A4 - N217Q (1)
Pain Link Frequency Relevance Heat
Serotonin 223 100.00 Very High Very High Very High
tolerance 62 100.00 Very High Very High Very High
cocaine 22 100.00 Very High Very High Very High
spastic colon 16 99.96 Very High Very High Very High
sSRI 37 99.82 Very High Very High Very High
imagery 14 99.80 Very High Very High Very High
Nicotine 204 99.76 Very High Very High Very High
antidepressant 146 99.76 Very High Very High Very High
positron emission tomography 6 99.64 Very High Very High Very High
antagonist 12 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obsessive-compulsive Disorder 4 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 99.96 Very High Very High Very High
Suicidal Behaviour 368 99.92 Very High Very High Very High
Nicotine Addiction 390 99.80 Very High Very High Very High
Toxicity 7 98.88 Very High Very High Very High
Fibromyalgia 104 98.60 Very High Very High Very High
Headache 6 98.48 Very High Very High Very High
Panic Disorder 66 98.28 Very High Very High Very High
Obesity 1 98.08 Very High Very High Very High
Functional Bowel Disorder 10 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Current data on the efficacy of SSRIs in IBS, association of the SERT gene promoter polymorphism 5-HTTLPR with IBS and the expression pattern of SERT in the intestinal mucosa of IBS patients are conflicting.
SERT Binding (association) of associated with spastic colon and ssri
1) Confidence 0.48 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.25 Pain Relevance 1.05
The present study investigated whether, in the absence of an amine nitrogen, certain non-amines bind selectively to the SERT and block the transport of serotonin.
SERT Binding (bind) of associated with serotonin
2) Confidence 0.48 Published 2001 Journal Synapse Section Abstract Doc Link 11746710 Disease Relevance 0 Pain Relevance 0.58
The minor G-allele is almost always in phase with the 5-HTTLPR long allele and reduces the transcriptional efficacy to the level associated with the 5-HTTLPR s-allele.
5-HTTLPR Binding (associated) of
3) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2717925 Disease Relevance 0.66 Pain Relevance 0.36
Differentiation of MEG-01 cells can provide considerable insight into interactions between SERT genetics, transmitter-hormonal/homeostatic mechanisms and signaling pathways.
SERT Binding (interactions) of in MEG-01
4) Confidence 0.42 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 20041293 Disease Relevance 0.25 Pain Relevance 0.09
Our hypothesis was that 5-HTTLPR would interact with an unfavourable family environment to predict increased risk for smoking, nicotine dependence, and nicotine and cotinine levels in hair samples.


5-HTTLPR Binding (interact) of in hair associated with addiction, nicotine addiction and nicotine
5) Confidence 0.42 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852756 Disease Relevance 0.68 Pain Relevance 0.60
Although several antidepressants (including fluoxetine, imipramine, citalopram, venlafaxine, and duloxetine) are known to inhibit the serotonin transporter (SERT), whether or not these molecules compete with 5-hydroxytryptamine (serotonin) (5-HT) for binding to SERT has remained controversial.
SERT Binding (binding) of associated with antidepressant, serotonin, duloxetine and fluoxetine
6) Confidence 0.42 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18801947 Disease Relevance 0 Pain Relevance 0.37
Thus, escitalopram shows a unique interaction with the hSERT compared with other 5-HT reuptake inhibitors (SSRIs) and, in addition to its 5-HT reuptake inhibitory properties, displays a pronounced effect via an affinity-modulating allosteric site.
hSERT Binding (interaction) of associated with ssri
7) Confidence 0.41 Published 2005 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 15695064 Disease Relevance 0.09 Pain Relevance 0.39
Replicated studies have demonstrated that the SERT 5'-flanking region polymorphism SS genotype is associated with poorer therapeutic responses and more frequent serious side effects during treatment with antidepressant SERT antagonists, namely, the serotonin reuptake inhibitors (SRIs).
SERT Binding (associated) of associated with antidepressant, antagonist and serotonin
8) Confidence 0.37 Published 2004 Journal Mol. Interv. Section Abstract Doc Link 15087484 Disease Relevance 0.63 Pain Relevance 0.35
Our studies establish a reference framework that will contribute to ongoing efforts to understand ligand binding modes at SERT by demonstrating that 5-HT and the SERT inhibitors tested bind to the serotonin transporter in a competitive manner.
serotonin transporter Binding (bind) of associated with serotonin
9) Confidence 0.37 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18801947 Disease Relevance 0 Pain Relevance 0.21
It is unknown, however, whether tegaserod interacts with the human serotonin reuptake transporter (hSERT) and the uptake transporters for dopamine (hDAT) and norepinephrine (hNET).
hSERT Spec (whether) Binding (interacts) of associated with dopamine and serotonin
10) Confidence 0.36 Published 2007 Journal Digestion Section Abstract Doc Link 17510552 Disease Relevance 0.18 Pain Relevance 0.32
Among the candidate genetic variants tested, a serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant treatment response.22
5-HTTLPR Binding (associated) of associated with antidepressant and serotonin
11) Confidence 0.36 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.55 Pain Relevance 0.53
Serotonin transporter mutations associated with obsessive-compulsive disorder and phosphorylation alter binding affinity for inhibitors.
Serotonin transporter Binding (affinity) of associated with obsessive-compulsive disorder and serotonin
12) Confidence 0.36 Published 2005 Journal Neuropharmacology Section Title Doc Link 16112691 Disease Relevance 0.19 Pain Relevance 0.68
Escitalopram affinity for hSERT and its 5-HT uptake inhibitory potency was in the nanomolar range and approximately 40-fold more potent than R-citalopram.
hSERT Binding (affinity) of associated with potency
13) Confidence 0.35 Published 2005 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 15695064 Disease Relevance 0.05 Pain Relevance 0.21
Adolescents from families with poor relations scored higher in the Fagerstrom Tolerance Index (P < 0.001) and had higher nicotine and cotinine levels in hair samples (P = 0.003, and P = 0.008, respectively). 5-HTTLPR heterozygous individuals also scored higher in the Fagerstrom Tolerance Index (P < 0.001), but a similar association with nicotine and cotinine levels in hair samples was not found.
5-HTTLPR Binding (association) of in hair associated with nicotine and tolerance
14) Confidence 0.33 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852756 Disease Relevance 0.24 Pain Relevance 0.48
A series of indole tetrahydropyridine and indole cyclohexenylamines was prepared, and their binding affinities at the human serotonin transporter (SERT) were determined.
SERT Binding (affinities) of associated with serotonin
15) Confidence 0.33 Published 2007 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 17391962 Disease Relevance 0 Pain Relevance 0.23
A series of indole tetrahydropyridine and indole cyclohexenylamines was prepared, and their binding affinities at the human serotonin transporter (SERT) were determined.
serotonin transporter Binding (affinities) of associated with serotonin
16) Confidence 0.33 Published 2007 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 17391962 Disease Relevance 0 Pain Relevance 0.22
OBJECTIVE: To study the association between the occurrence of migraine with aura and 5-HT(1B/1D) and 5-HT(2C) receptor gene and the human serotonin transporter (hSERT) gene polymorphisms in 18 unrelated families with multiple affected members.
hSERT Binding (association) of
17) Confidence 0.32 Published 2004 Journal Headache Section Body Doc Link 15109354 Disease Relevance 0.10 Pain Relevance 0
Our studies establish a reference framework that will contribute to ongoing efforts to understand ligand binding modes at SERT by demonstrating that 5-HT and the SERT inhibitors tested bind to the serotonin transporter in a competitive manner.
SERT Binding (bind) of associated with serotonin
18) Confidence 0.32 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18801947 Disease Relevance 0 Pain Relevance 0.21
Fluoxetine took more time to combine with hSERT than 5-HT did, and it was also slow to dissociate from hSERT.
hSERT Binding (combine) of
19) Confidence 0.32 Published 2006 Journal Acta Pharmacol. Sin. Section Body Doc Link 16490163 Disease Relevance 0 Pain Relevance 0
It is unknown, however, whether tegaserod interacts with the human serotonin reuptake transporter (hSERT) and the uptake transporters for dopamine (hDAT) and norepinephrine (hNET).
serotonin reuptake transporter Spec (whether) Binding (interacts) of associated with dopamine and serotonin
20) Confidence 0.32 Published 2007 Journal Digestion Section Abstract Doc Link 17510552 Disease Relevance 0.18 Pain Relevance 0.32

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