INT5774

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2010
Negated 8
Speculated 4
Reported most in Abstract
Documents 22
Total Number 26
Disease Relevance 4.97
Pain Relevance 7.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
TMJ 2
striatum 2
nucleus accumbens 2
caudate-putamen 1
gluteus medius 1
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 18 100.00 Very High Very High Very High
Pain threshold 14 100.00 Very High Very High Very High
Dopamine 20 99.68 Very High Very High Very High
substance P 10 99.12 Very High Very High Very High
Substantia nigra 6 98.56 Very High Very High Very High
agonist 8 98.44 Very High Very High Very High
Nucleus accumbens 11 98.40 Very High Very High Very High
epidural 4 98.12 Very High Very High Very High
antagonist 14 97.96 Very High Very High Very High
Nicotine 6 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 55 100.00 Very High Very High Very High
Generalized Anxiety Disorder 4 100.00 Very High Very High Very High
Hyperalgesia 50 97.96 Very High Very High Very High
Temporomandibular Joint Syndrome 16 97.12 Very High Very High Very High
Injury 9 96.76 Very High Very High Very High
Traumatic Shock 1 95.60 Very High Very High Very High
Stress 24 92.60 High High
INFLAMMATION 18 90.84 High High
Nociception 16 89.12 High High
Inflammatory Pain 20 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sham-operated rats, the blockade of 5-HT(2) receptors decreased PPE mRNA levels in the striatum and, by contrast, had no effect on PPT-A mRNA levels.
Neg (no) Regulation (effect) of PPT in striatum
1) Confidence 0.60 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.46
Repeated nicotine administration increases the PPE mRNA level in the rostral pole and the anterior third of the core without any change in PPT-A and PPDYN mRNA levels in the various Acb subregions examined.
Neg (without) Regulation (change) of PPT in Acb associated with nucleus accumbens and nicotine
2) Confidence 0.60 Published 1996 Journal Synapse Section Abstract Doc Link 8723714 Disease Relevance 0 Pain Relevance 0.46
These results suggest a post-transcriptional mechanism of PPT regulation.
Regulation (regulation) of PPT
3) Confidence 0.57 Published 1996 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8600937 Disease Relevance 0.18 Pain Relevance 0.45
The effects of acute and repeated daily cocaine on the levels of mRNA coding for glutamic acid decarboxylase (GAD), preproenkephalin (PPE), preprotachykinin (PPT), and the dopamine D2 receptor were determined in the striatum, nucleus accumbens core and shell areas (NAcore, NAshell), and medial prefrontal cortex.
Spec (determined) Regulation (effects) of PPT in striatum associated with nucleus accumbens, dopamine, generalized anxiety disorder and cocaine
4) Confidence 0.32 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609627 Disease Relevance 0.16 Pain Relevance 0.49
CORT replacement resulted in recovered PPE and PPT mRNA levels after 1 day and elevated PPE mRNA levels over those in sham-operated controls after 3 days.
Regulation (resulted) of PPT
5) Confidence 0.20 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9681476 Disease Relevance 0 Pain Relevance 0.33
The control vector did not significantly change PPT in inflamed paws or in contralateral noninflamed paws (p > 0.05, paired t- test; Fig. 5).
Neg (not) Regulation (change) of PPT
6) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.95 Pain Relevance 0.29
The mean of the second and third TMJ PPT was used in the analysis, and the ratio between the TMJ PPT and the PPT of the reference site (PPT ratio) was calculated.
Regulation (calculated) of TMJ PPT in TMJ
7) Confidence 0.18 Published 2003 Journal J Orofac Pain Section Body Doc Link 14737877 Disease Relevance 0.08 Pain Relevance 0
Intense PPE immunoreactivity was found in neuropil of the globus pallidus, whereas intense to moderate PPD and PPT immunoreactivity was distributed in neuropil of the substantia nigra and the entopeduncular nucleus.
Regulation (immunoreactivity) of PPT in substantia nigra associated with substantia nigra
8) Confidence 0.18 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9295149 Disease Relevance 0 Pain Relevance 0.08
Following the ultrasound intervention, PPT readings were recorded at 1, 3, 5, 10 and 15 min intervals at both infraspinatus and gluteus medius trigger points; the difference between infraspinatus and gluteus medius PPT values, PPT seg, represents the segmental influence on the PPT.
Regulation (influence) of PPT in infraspinatus
9) Confidence 0.17 Published 2008 Journal Pain Section Abstract Doc Link 18508198 Disease Relevance 0.38 Pain Relevance 0.59
A 3-way analysis of variance (ANOVA) with time (pre-post) and side (ipsilateral, contralateral to the intervention) as within-subjects variable and intervention (manipulation or MCI) as between-subjects variable was used to evaluate changes in PPT, HPT, CPT, or PFG.
Regulation (changes) of PPT
10) Confidence 0.16 Published 2008 Journal J Manipulative Physiol Ther Section Body Doc Link 19028251 Disease Relevance 0.11 Pain Relevance 0
Future studies with larger sample sizes are required to examine the effects of thrust manipulation on PPT, HPT, CPT, or PFG.


Spec (examine) Regulation (effects) of PPT
11) Confidence 0.16 Published 2008 Journal J Manipulative Physiol Ther Section Body Doc Link 19028251 Disease Relevance 0 Pain Relevance 0
PPD, PPE, and PPT C-terminal immunoreactivity was observed in many cell bodies of medium-sized neurons in the rat neostriatum (caudate-putamen).
Regulation (immunoreactivity) of PPT in caudate-putamen
12) Confidence 0.16 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9295149 Disease Relevance 0 Pain Relevance 0.04
To study whether block of the nervous supply to the traumatized tissue had any effect on PPT, 40 mg of mepivacaine was injected through an epidural catheter inserted between the second and third lumbar vertebrae in pigs.
Spec (whether) Regulation (effect) of PPT in vertebrae associated with epidural
13) Confidence 0.14 Published 1988 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3414349 Disease Relevance 0.49 Pain Relevance 0.20
No significant changes in PPT levels were found after the placebo and control interventions (P > .6).
Neg (No) Regulation (changes) of PPT
14) Confidence 0.14 Published 2007 Journal J Orthop Sports Phys Ther Section Body Doc Link 17612359 Disease Relevance 0 Pain Relevance 0
l) into inflamed paws did not significantly change PPT in inflamed paws or in contralateral noninflamed paws (p > 0.05, paired t-test; Fig. 3A).
Neg (not) Regulation (change) of PPT
15) Confidence 0.14 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.26 Pain Relevance 0.23
Fifteen days after CFA-treatment, changes in PPT were examined after injection of P2XR agonists or antagonists into the TMJ.
Regulation (changes) of PPT in TMJ associated with snapping jaw, pain threshold, antagonist and agonist
16) Confidence 0.12 Published 2005 Journal Pain Section Abstract Doc Link 15936887 Disease Relevance 1.36 Pain Relevance 1.55
The effects of acute and repeated daily cocaine on the levels of mRNA coding for glutamic acid decarboxylase (GAD), preproenkephalin (PPE), preprotachykinin (PPT), and the dopamine D2 receptor were determined in the striatum, nucleus accumbens core and shell areas (NAcore, NAshell), and medial prefrontal cortex.
Spec (determined) Regulation (effects) of PPT in nucleus accumbens associated with nucleus accumbens, dopamine, generalized anxiety disorder and cocaine
17) Confidence 0.11 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609627 Disease Relevance 0.16 Pain Relevance 0.49
In contrast, chronic administration of eticlopride, scopolamine or the two combined decreased striatal preprotachykinin (PPT) mRNA to the same extent, suggesting that there was no direct interaction between D2 dopaminergic and cholinergic mechanisms in the regulation of striatal PPT mRNA.
Regulation (regulation) of PPT mRNA
18) Confidence 0.09 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315917 Disease Relevance 0 Pain Relevance 0.31
The PPT and LDT are also the targets of descending projections from the auditory cortex (Schofield and Motts, 2009).
Regulation (targets) of PPT in auditory cortex
19) Confidence 0.08 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2972721 Disease Relevance 0 Pain Relevance 0.06
These data indicate that DA differentially regulates striatal PPE and PPT mRNA and suggest that dopaminergic regulation of striatal PPE mRNA is mediated in part through D2 DA effects on striatal cholinergic neurons.
Regulation (regulates) of PPT mRNA in cholinergic neurons associated with dopamine
20) Confidence 0.08 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315917 Disease Relevance 0 Pain Relevance 0.30

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