INT57746

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 1993
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.88

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lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
liver 4
Il1 (Mus musculus)
Ltc4s (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatitis 2 87.96 High High
Hepatotoxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with IL-1 significantly increased the synthesis of prostaglandin E2 (PGE2) in samples of liver tissue from AAP-treated mice, but had no effect on the synthesis of leukotriene C4 (LTC4).
IL-1 Neg (no) Regulation (effect) of Gene_expression (synthesis) of leukotriene C4 in liver associated with paracetamol
1) Confidence 0.36 Published 1993 Journal Cytokine Section Abstract Doc Link 8218930 Disease Relevance 0.16 Pain Relevance 0.44
Pretreatment with IL-1 significantly increased the synthesis of prostaglandin E2 (PGE2) in samples of liver tissue from AAP-treated mice, but had no effect on the synthesis of leukotriene C4 (LTC4).
IL-1 Neg (no) Regulation (effect) of Gene_expression (synthesis) of LTC4 in liver associated with paracetamol
2) Confidence 0.27 Published 1993 Journal Cytokine Section Abstract Doc Link 8218930 Disease Relevance 0.16 Pain Relevance 0.44

General Comments

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