INT57748

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 85
Total Number 91
Disease Relevance 79.55
Pain Relevance 7.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
melanocyte 9
colon 7
SNU-1 4
LoVo 4
epithelial cells 4
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 34 99.84 Very High Very High Very High
cINOD 124 99.48 Very High Very High Very High
Pain 26 98.26 Very High Very High Very High
Chronic pancreatitis 27 98.12 Very High Very High Very High
cytokine 33 97.78 Very High Very High Very High
fluoxetine 22 97.44 Very High Very High Very High
palliative 13 92.24 High High
antagonist 56 90.40 High High
Analgesic 17 89.56 High High
agonist 64 84.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 2954 100.00 Very High Very High Very High
Apoptosis 973 100.00 Very High Very High Very High
Pancreatic Ductal Carcinoma 34 100.00 Very High Very High Very High
Hyperplasia 117 99.92 Very High Very High Very High
Colon Cancer 262 99.84 Very High Very High Very High
Heart Rate Under Development 9 99.84 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 9 99.76 Very High Very High Very High
Reprotox - General 1 50 99.72 Very High Very High Very High
Melanoma 19 99.68 Very High Very High Very High
Infection 8 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the p53 gene, therefore, appears increased in the majority of pancreatic adenocarcinomas while this is not observed in chronic pancreatitis or normal pancreatic tissue.
Spec (appears) Positive_regulation (increased) of Gene_expression (expression) of p53 associated with adenocarcinoma and chronic pancreatitis
1) Confidence 0.69 Published 1993 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8218996 Disease Relevance 1.14 Pain Relevance 0.40
In our series of 49 BCC samples, we found several examples fitting into this pattern, but overall no significant correlation between p53 overexpression as an indication of p53 mutation and melanocyte colonization was found by statistical evaluation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 in melanocyte associated with basal cell carcinoma
2) Confidence 0.69 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.34 Pain Relevance 0.08
A limitation of our (and other's) interpretation of data is the heterogeneity of pigmentation, melanocyte colonization, and p53 overexpression in an individual tumor.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 in pigmentation associated with cancer
3) Confidence 0.69 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.42 Pain Relevance 0.07
Sequencing of the p53-gene in 10 selected samples demonstrated that p53 overexpression correlates with the presence of a mutation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53
4) Confidence 0.69 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.41 Pain Relevance 0.05
We further specifically evaluated associations with stage, histologic grade and TP53 overexpression of the tumor.


Positive_regulation (overexpression) of Gene_expression (overexpression) of TP53 associated with cancer
5) Confidence 0.68 Published 2007 Journal BMC Urol Section Body Doc Link PMC2018698 Disease Relevance 1.10 Pain Relevance 0.63
Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells.
Positive_regulation (increasing) of Gene_expression (expression) of TP53 in colon associated with inflammation, colon cancer, cinod and cytokine
6) Confidence 0.67 Published 2006 Journal Radiat. Res. Section Title Doc Link 16435911 Disease Relevance 0.94 Pain Relevance 0.24
After treatment with FLX, A549 and HT29 cells demonstrated concentration-dependent decrease in the expression of c-fos, c-jun, cyclin A, cyclin D1, and increased expression of p21(waf1) and p53 genes, which resulted in slowing of the cell cycle progression.
Positive_regulation (increased) of Gene_expression (expression) of p53 in HT29 associated with fluoxetine
7) Confidence 0.67 Published 2008 Journal Cancer Biol. Ther. Section Abstract Doc Link 18836303 Disease Relevance 0.72 Pain Relevance 0.85
A number of clinical studies demonstrated that intratumoral injection of Ad-p53 resulted in vector-mediated p53 gene expression in various types of tumors and thus produced antitumor activities (Clayman et al 1998; Habib et al 1999; Swisher et al 1999; Singh et al 2002).
Positive_regulation (mediated) of Gene_expression (expression) of p53 associated with cancer
8) Confidence 0.67 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.65 Pain Relevance 0
Nishikura et al. conducted a study in a total of 98 patients with gastric endocrine cell carcinoma or carcinoid tumor, and reported that patients with carcinoid tumor did not have any p53 protein overexpression or genetic mutation [3].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 protein in endocrine cell associated with carcinoid and carcinoma
9) Confidence 0.65 Published 2010 Journal BMC Urol Section Body Doc Link PMC3016340 Disease Relevance 1.75 Pain Relevance 0.16
Overexpression of p53 has been linked to decreased survival in several other malignancies.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of p53
10) Confidence 0.64 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.79 Pain Relevance 0
In our series, overexpression of p53 (70-95%) was negative in 8 cases and positive in 15 cases, predominantly in the sarcomatous regions as seen in Figure 1D.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53
11) Confidence 0.64 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.53 Pain Relevance 0
Mutation of serine 15 to alanine by site directed mutagenesis and overexpression of the mutated p53 gene in HCT116 cells, revealed that these cells are significantly less sensitive to apoptosis induced by R-flurbiprofen than pcDNA control cells, as measured by PARP-cleavage and flow cytometry.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 in cleavage associated with apoptosis
12) Confidence 0.63 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.70 Pain Relevance 0.11
The immunohistochemical analyses showed that 76% of the cases overexpressed the p53 protein.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of p53
13) Confidence 0.56 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.30 Pain Relevance 0.03
Colocalization studies in tissue-microarray slides revealed WISP-2/CCN5 mRNA loss was associated with p53 overexpression in PAC.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with heart rate under development
14) Confidence 0.56 Published 2007 Journal Cancer Lett. Section Abstract Doc Link 17383817 Disease Relevance 0.71 Pain Relevance 0.09
The transfection of a NAG1 siRNA into HCT116 cells suppressed radiation-induced apoptosis and inhibited the induction of NAG1 protein without altering the expression of TP53. a NAG1 luciferase promoter construct that included both of the TP53 binding sites, was activated by radiation in dose-dependent manner, while the promoters lacking one or both of the TP53 binding sites in the NAG1 promoter activity either was less responsive or did not respond.
Neg (without) Positive_regulation (altering) of Gene_expression (expression) of TP53 associated with apoptosis
15) Confidence 0.49 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.84 Pain Relevance 0.13
The expression of TP53 protein in HCT116 cells was increased after irradiation and was followed by an increase in the expression of NAG1 protein.
Positive_regulation (increased) of Gene_expression (expression) of TP53 protein
16) Confidence 0.49 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.94 Pain Relevance 0.16
Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis.
Positive_regulation (Pancreatic) of Gene_expression (expression) of p53 tumor suppressor gene associated with adenocarcinoma, cancer and chronic pancreatitis
17) Confidence 0.47 Published 1993 Journal Cancer Lett. Section Abstract Doc Link 8513440 Disease Relevance 0.83 Pain Relevance 0.33
Since p53 immunohistologically detectable overexpression in cancer cells is not always caused by inactivating mutations [9, 10], we sequenced exon 5-8 of the p53 gene in ten selected BCC samples to confirm that the p53 expression status is indeed a measure of p53 mutation in our BCC tissues.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 associated with cancer and basal cell carcinoma
18) Confidence 0.47 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.77 Pain Relevance 0
Surprisingly, we did not observe any correlation between melanocyte colonization and p53 overexpression, which is indicative of inactivating p53 mutations.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p53 in melanocyte
19) Confidence 0.47 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.95 Pain Relevance 0
Since p53 immunohistologically detectable overexpression in cancer cells is not always caused by inactivating mutations [9, 10], we sequenced exon 5-8 of the p53 gene in ten selected BCC samples to confirm that the p53 expression status is indeed a measure of p53 mutation in our BCC tissues.
Neg (not) Positive_regulation (caused) of Gene_expression (overexpression) of p53 associated with cancer and basal cell carcinoma
20) Confidence 0.47 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.83 Pain Relevance 0

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