INT57749

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 1993
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 39
Total Number 41
Disease Relevance 36.79
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
fibroblast 4
melanocyte 4
urothelial cells 3
lymph node 2
CAR 2
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 15 99.92 Very High Very High Very High
Pain 7 99.74 Very High Very High Very High
Potency 6 99.56 Very High Very High Very High
COX2 111 98.60 Very High Very High Very High
palliative 8 98.44 Very High Very High Very High
Morphine 10 97.84 Very High Very High Very High
Somatostatin 10 97.52 Very High Very High Very High
Chronic pancreatitis 20 93.64 High High
cytokine 18 89.36 High High
cINOD 48 87.20 High High
Disease Link Frequency Relevance Heat
Cancer 992 100.00 Very High Very High Very High
Apoptosis 466 100.00 Very High Very High Very High
Skin Cancer 22 100.00 Very High Very High Very High
Squamous Cell Carcinoma 5 100.00 Very High Very High Very High
Colon Cancer 178 99.84 Very High Very High Very High
Stomach Cancer 55 99.84 Very High Very High Very High
Thyroid Neoplasm 23 99.84 Very High Very High Very High
Metastasis 104 99.82 Very High Very High Very High
Ductal Carcinoma 2 99.78 Very High Very High Very High
Conjunctiva Disease 88 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abrogation of p53 expression by the antisense oligonucleotides significantly attenuated capsaicin-induced cell cycle arrest and apoptosis.
Negative_regulation (Abrogation) of Gene_expression (expression) of p53 associated with qutenza and apoptosis
1) Confidence 0.56 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14871840 Disease Relevance 0.65 Pain Relevance 1.11
The lack of p53 expression in some cases of pancreatic adenocarcinoma may be due to different types of mutant proteins not detectable by the CM1 antibody.
Negative_regulation (lack) of Gene_expression (expression) of p53 associated with adenocarcinoma
2) Confidence 0.43 Published 1993 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8218996 Disease Relevance 1.00 Pain Relevance 0.40
For this purpose, we selected six tumor samples displaying macroscopic pigmentation, a relative high proportion of melanin positive cells, as well as p53 overexpression and four nonpigmented BCCs poor in melanocytes and lacking detectable p53 expression.
Negative_regulation (lacking) of Gene_expression (expression) of p53 in melanocytes associated with cancer
3) Confidence 0.43 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.88 Pain Relevance 0
One finding of Cui and colleagues supporting the central role of keratinocytic p53 in melanocyte activation was the tight correlation they found in 23 BCCs with only the 15 p53 wild-type tumors showing melanocyte colonization while the 8 BCCs for which they detected p53-inactivating mutations lacked cells expressing the melanocytic marker MITF [4].
Negative_regulation (detected) of Gene_expression (mutations) of p53-inactivating in melanocyte associated with cancer
4) Confidence 0.43 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.42 Pain Relevance 0.08
Expression of dominant negative p53 in LNCaP cells blocked induction of PDF mRNA and protein demonstrating the requirement for functional p53 in PDF induction by these stimuli.
Negative_regulation (blocked) of Gene_expression (Expression) of p53
5) Confidence 0.41 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.89 Pain Relevance 0.24
Heterogenous or decreased CAR expression in tumors also hampered ONYX-015-mediated antitumor effects as observed in the case of Ad-p53 (Zeimet and Marth 2003).
Negative_regulation (decreased) of Gene_expression (expression) of p53 in CAR associated with cancer
6) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 1.14 Pain Relevance 0
Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer.
Negative_regulation (evaluation) of Gene_expression (expression) of p53 associated with esophageal cancer
7) Confidence 0.40 Published 2004 Journal Int. J. Cancer Section Title Doc Link 15170665 Disease Relevance 0.92 Pain Relevance 0
Combined immunohistochemical evaluation of HIF-1alpha, p53 and p21 protein expression at the pretreatment biopsy is a very useful and powerful indicator of sensitivity to CRT in human esophageal cancer.
Negative_regulation (evaluation) of Gene_expression (expression) of p53 associated with esophageal cancer
8) Confidence 0.40 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.69 Pain Relevance 0.10
In our series, overexpression of p53 (70-95%) was negative in 8 cases and positive in 15 cases, predominantly in the sarcomatous regions as seen in Figure 1D.
Negative_regulation (positive) of Gene_expression (overexpression) of p53
9) Confidence 0.39 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.58 Pain Relevance 0
The third aim of this study was to examine the expression of COX-2, p53, and Ki-67 in gastric cancer and their relationship with clinicopathological characteristics including patient prognosis.
Spec (examine) Negative_regulation (examine) of Spec (examine) Gene_expression (expression) of p53 associated with stomach cancer
10) Confidence 0.39 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 1.04 Pain Relevance 0
The aim of this study was to evaluate the expression of COX-2 and p53 in gastric cancer and to examine the relationship between their expression and various clinicopathological characteristics including tumor cell proliferation.


Negative_regulation (evaluate) of Gene_expression (expression) of p53 associated with cancer and stomach cancer
11) Confidence 0.39 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 1.17 Pain Relevance 0
As positive nuclear staining was homogenous, evaluation of Top IIa, KI 67 and p53 expression was done according to the percentage of positively stained cells only, regardless of the intensity.
Negative_regulation (evaluation) of Gene_expression (expression) of p53
12) Confidence 0.37 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410751 Disease Relevance 0.06 Pain Relevance 0
The abnormal p53 expression has been found in 11% of grade 1 endometrioid endometrial carcinoma [18].
Negative_regulation (abnormal) of Gene_expression (expression) of p53 associated with endometrial cancer
13) Confidence 0.37 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.93 Pain Relevance 0
The loss of p53 tumor suppressor function will activate some of these potential oncogenic miRNAs.
Negative_regulation (loss) of Gene_expression (function) of p53 associated with cancer
14) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.60 Pain Relevance 0
In addition to the rarity of the tumor, the present case suggests the malignant potency of the tumor despite lack of bcl-2 and p53 expression, which has been known as a marker for malignancy of neuroendocrine tumors [2-5].


Negative_regulation (lack) of Gene_expression (expression) of p53 associated with malignant neoplastic disease, neuroendocrine cancer, cancer and potency
15) Confidence 0.35 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.30 Pain Relevance 0.05
Furthermore, we found lymph node metastasis despite lack of bcl-2 and p53 expression.
Negative_regulation (lack) of Gene_expression (expression) of p53 in lymph node associated with metastasis
16) Confidence 0.35 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2874790 Disease Relevance 0.98 Pain Relevance 0.18
Only at concentrations as high as 5 mM ALA, p53 mRNA expression was 25% diminished.
Negative_regulation (diminished) of Gene_expression (expression) of p53 mRNA
17) Confidence 0.34 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.59 Pain Relevance 0
Our study compared clinical findings and expression of p53, Bcl-2 and caspase-3 in patients with GAP versus healthy controls.
Negative_regulation (compared) of Gene_expression (expression) of p53 associated with periodontitis
18) Confidence 0.33 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 0.99 Pain Relevance 0.08
When we evaluated DNA repair by CFGE and assessed mobile DNA fragments after high dose exposure we found unequivocal evidence that Pentoxifylline effectively suppresses DNA double strand break repair in p53 mutant human melanoma and squamous cell carcinoma lines [45] and various p53 transfectants [5].
Negative_regulation (suppresses) of Gene_expression (transfectants) of p53 associated with squamous cell carcinoma and skin cancer
19) Confidence 0.31 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.20 Pain Relevance 0
Furthermore, downregulation of p53 expression could also play a role.
Negative_regulation (downregulation) of Gene_expression (expression) of p53
20) Confidence 0.30 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.52 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox