INT57763

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 7.11
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Lmna) structural molecule activity (Lmna) nucleus (Lmna)
cytoplasm (Lmna)
Anatomy Link Frequency
bone marrow 2
brain 2
immune cell 2
B cell 2
lymphocyte 2
Lmna (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
cytokine 118 99.98 Very High Very High Very High
Antinociceptive 9 99.84 Very High Very High Very High
imagery 44 99.80 Very High Very High Very High
Spinal cord 21 99.68 Very High Very High Very High
Substantia nigra 102 99.08 Very High Very High Very High
Inflammation 91 98.94 Very High Very High Very High
mu opioid receptor 1 98.20 Very High Very High Very High
Physical dependence 2 96.08 Very High Very High Very High
interneuron 20 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 99 99.08 Very High Very High Very High
Arthritis 22 98.94 Very High Very High Very High
Mycobacterial Infection 141 98.88 Very High Very High Very High
Parkinson's Disease 534 98.68 Very High Very High Very High
Drug Dependence 2 96.08 Very High Very High Very High
Drug Induced Neurotoxicity 42 93.52 High High
Disease 279 92.32 High High
Pain 12 92.04 High High
Cancer 71 90.52 High High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 4 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bone marrow chimeras were generated to test the possibility that lamin A/C expression is required in developing lymphocytes for normal T and B cell maturation.
Gene_expression (expression) of lamin in B cell
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.20 Pain Relevance 0
Together, these data show that intrinsic lamin A/C expression is not required either for B cell development or for T cell development and function.
Gene_expression (expression) of lamin in B cell
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.08 Pain Relevance 0.04
Further, it implies the possibility that A-type lamin expression in non-hematopoietic cells influences the function and development of these lymphocytes.


Gene_expression (expression) of lamin in lymphocytes
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0 Pain Relevance 0.07
This implies that A-type lamin function/expression is not required in these cell types for normal development and homeostasis.
Gene_expression (function) of lamin
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0 Pain Relevance 0.08
A second possible explanation for the lymphocyte developmental defects observed in Lmna-/- mice is that stromal elements within primary lymphoid organs require lamin A/C expression for their function in promoting normal T and B cell development.
Gene_expression (expression) of lamin in lymphocyte
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.07 Pain Relevance 0.04
After induction of knee joint inflammation, ROS was observed in the spinal cord of animals pre-injected with the ROS indicator dye DHE (Fig. 3A).
Gene_expression (injected) of DHE in spinal cord associated with inflammation, arthritis and spinal cord
6) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.40 Pain Relevance 0.48
Therefore, the altered immune cell development is not specific to loss of Lmna expression in developing lymphocytes or thymic epithelial cells, but likely an indirect effect of loss of lamin expression in other non-lymphoid tissues.


Gene_expression (expression) of lamin in immune cell
7) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.13 Pain Relevance 0.03
+ effector cells were generated at the same frequency and demonstrated the same cytokine-producing potential from Lmna-/- and Lmna+/+ cells within the same mixed bone marrow chimeras.
Gene_expression (producing) of Lmna in bone marrow associated with cytokine
8) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.15 Pain Relevance 0.05
+ effector cells were generated at the same frequency and demonstrated the same cytokine-producing potential from Lmna-/- and Lmna+/+ cells within the same mixed bone marrow chimeras.
Gene_expression (producing) of Lmna in bone marrow associated with cytokine
9) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.15 Pain Relevance 0.05
Regardless of the route of systemic and local administration, DHE (1-20 micrograms/kg, i.p.; 1-10 micrograms/kg, s.c.; 1-10 micrograms/kg, i.v.; 10-1000 micrograms/kg, p.o.; 10-100 ng/mouse, intracerebroventricularly (i.c.v.); and 10-100 ng/mouse, intrathecally (i.t.)) and morphine (1-20 mg/kg, i.p.; 1-10 mg/kg, s.c.; 1-10 mg/kg, i.v.; 10-100 mg/kg, p.o.; 1-10 micrograms/mouse, i.c.v.; and 0.5-3 micrograms/mouse, i.t.) produced an antinociceptive effect in a dose-dependent manner, as evaluated by the tail pinch method.
Gene_expression (produced) of DHE in tail associated with antinociceptive and morphine
10) Confidence 0.53 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8924922 Disease Relevance 0 Pain Relevance 0.87
Thus, we demonstrated that DHE produces the antinociceptive effect mediated through mu opioid receptors without causing development of a physical dependence, suggesting that it is safe to use in the clinical therapy of patients suffering severe pain such as that accompanying cancer.
Gene_expression (produces) of DHE associated with pain, physical dependence, cancer, mu opioid receptor and antinociceptive
11) Confidence 0.53 Published 1993 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8220323 Disease Relevance 0.37 Pain Relevance 1.21
Therefore, the altered immune cell development is not specific to loss of Lmna expression in developing lymphocytes or thymic epithelial cells, but likely an indirect effect of loss of lamin expression in other non-lymphoid tissues.


Gene_expression (expression) of Lmna in immune cell
12) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.14 Pain Relevance 0.03
One gene, LMNA, encodes the A-type nuclear lamins, which produce the predominant A-type lamin proteins A and C.
Gene_expression (produce) of lamin
13) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.53 Pain Relevance 0
This implies that A-type lamin function/expression is not required in these cell types for normal development and homeostasis.
Gene_expression (expression) of lamin
14) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0 Pain Relevance 0.08
A DHE fluorescence signal is detected when DHE and O2•?
Gene_expression (detected) of DHE
15) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.42 Pain Relevance 0.20
In our experiment, DHE intensity was not significantly reduced by hydrogen water in MPTP-treated mice, indicating that hydrogen water showed less or no reduction of O2•?.
Gene_expression (intensity) of DHE associated with parkinson's disease
16) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.43 Pain Relevance 0.15
Although some microglia in the SN were activated in 24 h, we can conclude that DHE signals which we observed in 24 h after MPTP injection mostly reflected neuronal O2•?
Gene_expression (signals) of DHE in neuronal associated with parkinson's disease and substantia nigra
17) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.45 Pain Relevance 0.19
When DHE is oxidized by O2•?
Gene_expression (oxidized) of DHE
18) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.71 Pain Relevance 0.14
So, DHE is widely used for imaging intracellular O2•?
Gene_expression (used) of DHE associated with imagery
19) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.42 Pain Relevance 0.20
A DHE fluorescence signal is detected when DHE and O2•?
Gene_expression (detected) of DHE
20) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.42 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox