INT57773

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Context Info
Confidence 0.08
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.23
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrng)
Anatomy Link Frequency
brain 1
cortex 1
hindbrain 1
Chrng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1 100.00 Very High Very High Very High
Clonidine 6 99.18 Very High Very High Very High
Potency 1 90.48 High High
midbrain 3 89.16 High High
antagonist 2 84.32 Quite High
Delta opioid receptors 1 70.52 Quite High
Physical dependence 1 66.64 Quite High
tolerance 1 65.64 Quite High
Opioid 1 62.92 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 98.42 Very High Very High Very High
Drug Dependence 1 66.64 Quite High
Poisoning 1 65.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, marked reduction in the levels of brain ChE is not the only factor involved in the production of mAChR downregulation to cholinesterase inhibitors.
Gene_expression (production) of mAChR in brain
1) Confidence 0.08 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8221166 Disease Relevance 0 Pain Relevance 0.21
Clonidine pretreatment reversed the soman-induced mAChR downregulation in cortex and hindbrain produced by acute soman administration.
Gene_expression (produced) of mAChR in hindbrain associated with clonidine
2) Confidence 0.06 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8221166 Disease Relevance 0 Pain Relevance 0.22
Pertussis toxin pretreatment did not prevent the ethanol-induced increase in alpha 2AR, mAChR, and delta-opioid receptor expression.
Gene_expression (expression) of mAChR associated with bordatella infection and opioid receptor
3) Confidence 0.04 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8226869 Disease Relevance 0.23 Pain Relevance 0.34
Clonidine pretreatment reversed the soman-induced mAChR downregulation in cortex and hindbrain produced by acute soman administration.
Gene_expression (produced) of mAChR in cortex associated with clonidine
4) Confidence 0.02 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8221166 Disease Relevance 0 Pain Relevance 0.22

General Comments

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