INT5778

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 1995
Negated 1
Speculated 5
Reported most in Abstract
Documents 4
Total Number 9
Disease Relevance 2.47
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
motoneurons 6
Dorsal root ganglia 4
dorsal horn 4
spinal 2
sympathetic 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 71 100.00 Very High Very High Very High
substance P 23 100.00 Very High Very High Very High
qutenza 16 100.00 Very High Very High Very High
calcitonin gene related peptide 10 100.00 Very High Very High Very High
Eae 8 99.62 Very High Very High Very High
Neuropeptide 8 99.28 Very High Very High Very High
Dorsal horn 4 97.00 Very High Very High Very High
Arthritis 8 96.80 Very High Very High Very High
Spinal cord 2 96.24 Very High Very High Very High
Hyperalgesia 2 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 10 100.00 Very High Very High Very High
Injury 8 99.62 Very High Very High Very High
Arthritis 8 96.80 Very High Very High Very High
Hyperalgesia 2 95.72 Very High Very High Very High
Nervous System Injury 5 94.24 High High
INFLAMMATION 2 90.24 High High
Neuropathic Pain 2 75.00 Quite High
Paralysis 6 63.68 Quite High
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that calcitonin gene-related peptide (CGRP) mRNA steady-state levels and CGRP immunoreactivity in motoneurons of the spinal nucleus of the bulbocavernosus (SNB) are inversely related to the gonadal steroid environment in male rats.
Regulation (related) of Transcription (levels) of calcitonin gene-related peptide in motoneurons associated with calcitonin gene-related peptide
1) Confidence 0.45 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0 Pain Relevance 0.33
Previous studies have shown that calcitonin gene-related peptide (CGRP) mRNA steady-state levels and CGRP immunoreactivity in motoneurons of the spinal nucleus of the bulbocavernosus (SNB) are inversely related to the gonadal steroid environment in male rats.
Regulation (related) of Transcription (levels) of CGRP in motoneurons associated with calcitonin gene-related peptide
2) Confidence 0.45 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0 Pain Relevance 0.33
This study examined the effect of neonatal administration of capsaicin on nociceptive threshold and the distribution of calcitonin gene-related peptide (CGRP), substance P (SP), and fluoride-resistant acid phosphatase (FRAP) in the dorsal horn of the spinal cord during the course of development (10 days to 12 weeks of age) in the rat.
Spec (examined) Regulation (effect) of Transcription (distribution) of calcitonin gene-related peptide in dorsal horn associated with nociception, qutenza, dorsal horn, spinal cord, substance p and calcitonin gene-related peptide
3) Confidence 0.45 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1721077 Disease Relevance 0.17 Pain Relevance 0.65
This study examined the effect of neonatal administration of capsaicin on nociceptive threshold and the distribution of calcitonin gene-related peptide (CGRP), substance P (SP), and fluoride-resistant acid phosphatase (FRAP) in the dorsal horn of the spinal cord during the course of development (10 days to 12 weeks of age) in the rat.
Spec (examined) Regulation (effect) of Transcription (distribution) of CGRP in dorsal horn associated with nociception, qutenza, dorsal horn, spinal cord, substance p and calcitonin gene-related peptide
4) Confidence 0.45 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1721077 Disease Relevance 0.17 Pain Relevance 0.65
In adult animals treated as neonates with the sympathetic neurotoxin 6-hydroxydopamine, a virtual absence of TH-IR and NPY-IR fibers was observed, whereas the distribution of CGRP-IR and SP-IR fibers appeared unaltered.
Spec (appeared) Regulation (unaltered) of Transcription (distribution) of CGRP-IR in sympathetic associated with substance p and calcitonin gene-related peptide
5) Confidence 0.44 Published 1990 Journal Cell Tissue Res. Section Abstract Doc Link 1973633 Disease Relevance 0 Pain Relevance 0.58
Dorsal root ganglia taken from animals with CCI were analyzed for alterations in mRNA levels encoding growth-associated protein-43 (GAP-43), calcitonin gene-related peptide (CGRP), galanin (GAL), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal polypeptide (VIP).
Spec (analyzed) Regulation (alterations) of Spec (analyzed) Transcription (levels) of CGRP in Dorsal root ganglia associated with eae, neuropeptide, substance p and calcitonin gene-related peptide
6) Confidence 0.41 Published 1994 Journal Pain Section Abstract Doc Link 7526320 Disease Relevance 0.63 Pain Relevance 0.71
Dorsal root ganglia taken from animals with CCI were analyzed for alterations in mRNA levels encoding growth-associated protein-43 (GAP-43), calcitonin gene-related peptide (CGRP), galanin (GAL), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal polypeptide (VIP).
Spec (analyzed) Regulation (alterations) of Spec (analyzed) Transcription (levels) of calcitonin gene-related peptide in Dorsal root ganglia associated with eae, neuropeptide, substance p and calcitonin gene-related peptide
7) Confidence 0.41 Published 1994 Journal Pain Section Abstract Doc Link 7526320 Disease Relevance 0.63 Pain Relevance 0.71
The role of target muscles in the expression of calcitonin gene-related peptide mRNA in the spinal nucleus of the bulbocavernosus.
Regulation (role) of Transcription (expression) of calcitonin gene-related peptide in spinal associated with calcitonin gene-related peptide
8) Confidence 0.27 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1315918 Disease Relevance 0.06 Pain Relevance 0.40
Budesonide had no effect on constitutive CGRP mRNA levels in motoneurons and attenuated the decrease in CGRP mRNA levels in motoneurons of rats subjected to CIA.
Neg (no) Regulation (effect) of Transcription (levels) of CGRP in motoneurons associated with calcitonin gene related peptide and arthritis
9) Confidence 0.26 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846393 Disease Relevance 0.79 Pain Relevance 1.03

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