INT57785

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 5.01
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SGCB) cytoskeleton organization (SGCB) cytoplasm (SGCB)
Anatomy Link Frequency
neurons 1
salivary gland 1
upper 1
SGCB (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 46 99.72 Very High Very High Very High
Inflammation 21 98.88 Very High Very High Very High
cINOD 1 98.60 Very High Very High Very High
agonist 253 98.12 Very High Very High Very High
nociceptor 1 96.24 Very High Very High Very High
Glutamate 23 88.80 High High
tolerance 34 86.20 High High
Inflammatory response 3 85.00 Quite High
Potency 22 84.44 Quite High
Angina 15 80.80 Quite High
Disease Link Frequency Relevance Heat
Carcinoma 274 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 47 99.58 Very High Very High Very High
INFLAMMATION 25 98.88 Very High Very High Very High
Disease 99 94.80 High High
Sprains And Strains 42 92.20 High High
Contracture 3 91.20 High High
Coronavirus Infection 1 90.16 High High
Common Cold 2 89.24 High High
Influenza Virus Infection 3 88.44 High High
Cancer 132 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unequivocally, nitroglycerine and most other organic nitrates, including NO-NSAIDs, do not behave as NO donors in the most fundamental action: in vitro activation of sGC to produce cGMP.
Positive_regulation (activation) of sGC associated with cinod
1) Confidence 0.69 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451053 Disease Relevance 0.08 Pain Relevance 0.22
Increased expression of SPHK1 is correlated with the clinical features of SGC
Positive_regulation (features) of SGC associated with carcinoma
2) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949806 Disease Relevance 0.85 Pain Relevance 0
SPHK1 expression was found to be markedly upregulated in SGC tissues than that in the normal salivary gland tissues and paired adjacent salivary gland tissues, at both mRNA and protein levels.
Positive_regulation (upregulated) of SGC in salivary gland associated with carcinoma
3) Confidence 0.24 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2949806 Disease Relevance 0.73 Pain Relevance 0
Expression of SPHK1 is upregulated in SGC
Positive_regulation (upregulated) of SGC associated with carcinoma
4) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949806 Disease Relevance 0.42 Pain Relevance 0
NO in turn activates sGC leading to a rise in intracellular cGMP and, in turn, activation of cGMP-dependent PKG, or cGK [54, 55].
Positive_regulation (activates) of sGC
5) Confidence 0.19 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11
In the absence of NAD, the E268Q mutant exhibited similar rates of GTN denitration as the wild type enzyme, but surprisingly generation of superoxide occurring in the course of GTN denitration was reduced, resulting in increased NO bioavailability and enhanced sGC activation in the absence of SOD.
Positive_regulation (activation) of sGC associated with bioavailability
6) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.16
Hence, in addition to the agonist-mediated PKC-feedback mechanism, engagement of the NO-cGMP signalling pathway through U46619-activation of the NOS/sGC/PKG pathway plays a significant role in inducing homologous desensitization of TP?
Neg (NO) Positive_regulation (activation) of sGC associated with agonist
7) Confidence 0.14 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
NO, in turn, activates the soluble form of guanylate cyclase (sGC) leading to a rise in intracellular cGMP and activation of PKG [52–55].
Positive_regulation (activates) of sGC
8) Confidence 0.13 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05
As shown in Fig. 2A, GTN caused biphasic activation of sGC in the presence of both ALDH2 variants with apparent EC50 values of 3.4 ± 0.20 and 15 ± 1.5 ?
Positive_regulation (activation) of sGC
9) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
Maximal sGC activation was determined in the presence of 10 ?
Positive_regulation (activation) of sGC
10) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
Alda-1 caused slight inhibition of GTN denitration and did not increase GTN-induced sGC activation in the presence of either variant.
Positive_regulation (activation) of sGC
11) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04
Because sGC activation by both variants was virtually identical in the presence of the superoxide scavenger SOD (data not shown), the higher efficiency of ALDH2*2 in the absence of SOD appears to reflect reduced superoxide generation and consequently increased NO bioavailability in the course of ALDH2*2-catalyzed GTN turnover.
Positive_regulation (activation) of sGC associated with bioavailability
12) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.12
Upon short term incubation (1 min), ALDH2*1 caused approximately half-maximal sGC activation in the presence of 1 ?
Positive_regulation (activation) of sGC
13) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.05
In addition, our data revealed an unexpected discrepancy between GTN reductase activity and sGC activation, suggesting that GTN denitration and bioactivation may reflect independent pathways of ALDH2-catalyzed GTN biotransformation.



Positive_regulation (activation) of sGC
14) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04
The apparent discrepancy between GTN denitration and sGC activation became even more evident at higher ALDH2 concentrations.
Positive_regulation (activation) of sGC
15) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
Alda-1 did not increase the efficiency of the Asian variant but slightly inhibited sGC activation by both enzymes in the absence and presence of NAD.



Positive_regulation (activation) of sGC
16) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04
The major nitrogen-containing product of GTN denitration is inorganic nitrite (4), but we found that ALDH2 additionally catalyzes formation of NO, detectable by a Clark-type NO electrode and as activation of purified sGC (11).
Positive_regulation (activation) of sGC
17) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.07 Pain Relevance 0
nitrovasodilators and NO activated the sGC, which
Neg (NO) Positive_regulation (activated) of sGC
18) Confidence 0.09 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.32 Pain Relevance 0.03
The antianginal drug nitroglycerin (glyceryl trinitrate (GTN))2 causes vasodilation through NO-mediated activation of vascular sGC (1–3).
Neg (NO) Positive_regulation (activation) of sGC associated with increased venous pressure under development
19) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.10 Pain Relevance 0
Both NO and CO activate soluble-guanilyl cyclase (sGC), thus inducing and increase in intracellular cyclic-guanilyl monophosphate (cGMP) as second messenger [8,9].
Positive_regulation (activate) of sGC
20) Confidence 0.05 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2586020 Disease Relevance 0.48 Pain Relevance 0.22

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