INT5779

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.61
Pain Relevance 10.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
plasma 14
dorsal root ganglion 6
trigeminal ganglia 2
levator ani 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 135 100.00 Very High Very High Very High
calcitonin gene related peptide 10 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Inflammation 19 99.72 Very High Very High Very High
Arthritis 8 99.56 Very High Very High Very High
qutenza 25 99.30 Very High Very High Very High
Migraine 11 97.68 Very High Very High Very High
Pain 3 97.16 Very High Very High Very High
withdrawal 1 96.60 Very High Very High Very High
nMDA receptor 1 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 15 99.72 Very High Very High Very High
Heat Stress Disorders 6 99.60 Very High Very High Very High
Arthritis 8 99.56 Very High Very High Very High
Neurogenic Inflammation 1 98.88 Very High Very High Very High
Paralysis 2 98.56 Very High Very High Very High
Headache 11 97.68 Very High Very High Very High
Pain 3 97.16 Very High Very High Very High
Fever 3 96.68 Very High Very High Very High
Ganglion Cysts 11 94.24 High High
Cancer 1 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CGRP mRNA expression was increased in the dorsal root ganglion (DRG) at 2 and 4 wk, whereas PGE and iNOS mRNAs were markedly increased at 2 wk.
Positive_regulation (increased) of Transcription (expression) of CGRP in dorsal root ganglion
1) Confidence 0.62 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19762759 Disease Relevance 0.06 Pain Relevance 0
Treatment with Rut significantly increased the synthesis and release of CGRP, as shown by the increase in the levels of CGRP mRNA and peptide in the dorsal root ganglia, the density of CGRP immunoreactive nerve fibers in the mesenteric artery, the CGRP content in the spinal cord and the plasma concentration of CGRP, which was markedly attenuated by pretreatment with capsaicin.
Positive_regulation (increase) of Transcription (levels) of CGRP in plasma
2) Confidence 0.50 Published 2004 Journal J. Hypertens. Section Body Doc Link 15311112 Disease Relevance 0 Pain Relevance 0
GeneChip analysis revealed that neither estrogen nor contraction alone changed the mRNA expression of substance P, the neurokinin-1 receptor, CGRP, NGF, the P2X3 receptor, GABAA and GABAB, the 5-HT3A and 5-HT3B receptor, N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors, opioid receptors, and opioid-like receptor.
Neg (neither) Positive_regulation (changed) of Transcription (expression) of CGRP associated with nmda receptor, opioid receptor, opioid and substance p
3) Confidence 0.49 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16306253 Disease Relevance 0.29 Pain Relevance 0.82
Thus upregulation of CGRP mRNA and iCGRP levels are temporally related to the development of inflammation and lowered pain thresholds.
Positive_regulation (upregulation) of Transcription (levels) of CGRP associated with pain, inflammation and calcitonin gene-related peptide
4) Confidence 0.47 Published 2006 Journal Neuroscience Section Abstract Doc Link 17027165 Disease Relevance 0.90 Pain Relevance 0.92
Pretreatment with preconditioning significantly reduced infarct size and the release of creatine kinase during reperfusion, and caused a significant increase in the expression of CGRP mRNA, concomitantly with an elevation in the plasma level of CGRP and NO.
Positive_regulation (caused) of Transcription (expression) of CGRP in plasma associated with calcitonin gene-related peptide
5) Confidence 0.46 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464099 Disease Relevance 0.42 Pain Relevance 0.72
Pretreatment with preconditioning significantly reduced infarct size and the release of creatine kinase during reperfusion, and caused a significant increase in the expression of CGRP mRNA, concomitantly with an elevation in the plasma level of CGRP and NO.
Positive_regulation (increase) of Transcription (expression) of CGRP in plasma associated with calcitonin gene-related peptide
6) Confidence 0.46 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464099 Disease Relevance 0.42 Pain Relevance 0.72
Studies in cultured trigeminal neurons demonstrate that CGRP is released from trigeminal ganglia cells, that CGRP transcription is increased under conditions mimicking neurogenic inflammation, that migraine pharmacotherapies can both reduce CGRP release and inhibit CGRP transcription, and that tumor necrosis factor-alpha (TNF-alpha), an endogenous inflammatory mediator implicated in migraine, can stimulate CGRP transcription.
Positive_regulation (increased) of Transcription (transcription) of CGRP in trigeminal ganglia associated with necrosis, inflammation, cancer, migraine, neurogenic inflammation and calcitonin gene-related peptide
7) Confidence 0.46 Published 2006 Journal Headache Section Abstract Doc Link 16927957 Disease Relevance 1.20 Pain Relevance 1.59
CIA caused a significant increase in CGRP mRNA levels in DRG.
Positive_regulation (increase) of Transcription (levels) of CGRP in DRG associated with calcitonin gene related peptide and arthritis
8) Confidence 0.45 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846393 Disease Relevance 0.77 Pain Relevance 0.93
The effect of ovariectomy on the release or synthesis was evaluated by measuring CGRP concentration in plasma after capsaicin (1.0 mg/kg, i.p.) injection or by measuring CGRP concentration and its mRNA expression in dorsal root ganglia in OVX rats.
Positive_regulation (measuring) of Transcription (expression) of CGRP in dorsal root ganglia associated with qutenza and calcitonin gene-related peptide
9) Confidence 0.44 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501156 Disease Relevance 0 Pain Relevance 0.53
The expression of alpha-CGRP mRNA in DRG (122.87+/-3.67 arbitrary units, p<0.05), the level of CGRP in the plasma (75.40+/-4.99 pg/ml, p<0.01) and the density of CGRP-ir fibers in mesenteric artery (525.67+/-31.42 intersections, p<0.05) were significantly increased in 2K1C rats.
Positive_regulation (increased) of Transcription (expression) of alpha-CGRP in plasma associated with calcitonin gene-related peptide
10) Confidence 0.41 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12832107 Disease Relevance 0.29 Pain Relevance 1.10
IS administration caused a significant increase of CGRP levels after 2 and 15 min compared with baseline.
Positive_regulation (increase) of Transcription (levels) of CGRP associated with calcitonin gene-related peptide
11) Confidence 0.41 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19558535 Disease Relevance 0.25 Pain Relevance 0.72
Injections of extract prepared from the bulbocavernosus and levator ani muscles of gonadally intact rats did not change the expression of alpha-CGRP mRNA in the SNB.
Neg (not) Positive_regulation (change) of Transcription (expression) of alpha-CGRP in levator ani associated with calcitonin gene-related peptide
12) Confidence 0.41 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.26 Pain Relevance 0.57
Heat stress also significantly increased plasma concentrations of CGRP and the expression of alpha-CGRP mRNA, but not beta-CGRP mRNA.
Positive_regulation (increased) of Transcription (expression) of alpha-CGRP in plasma associated with heat stress disorders and calcitonin gene-related peptide
13) Confidence 0.41 Published 2002 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 12060099 Disease Relevance 0.75 Pain Relevance 0.71
Monophosphoryl lipid A caused a significant increase in the expression of alpha-CGRP mRNA, but not of beta-CGRP mRNA, concomitantly with an increase in plasma concentrations of CGRP, and the increased level of CGRP expression happened before stimulation of CGRP release.
Neg (not) Positive_regulation (caused) of Transcription (expression) of alpha-CGRP in plasma associated with calcitonin gene-related peptide
14) Confidence 0.41 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11834251 Disease Relevance 0 Pain Relevance 0.76
Monophosphoryl lipid A caused a significant increase in the expression of alpha-CGRP mRNA, but not of beta-CGRP mRNA, concomitantly with an increase in plasma concentrations of CGRP, and the increased level of CGRP expression happened before stimulation of CGRP release.
Positive_regulation (increase) of Transcription (expression) of alpha-CGRP in plasma associated with calcitonin gene-related peptide
15) Confidence 0.41 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11834251 Disease Relevance 0 Pain Relevance 0.76

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