INT5781

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 1
Speculated 5
Reported most in Abstract
Documents 190
Total Number 195
Disease Relevance 99.10
Pain Relevance 46.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 18
blood 13
kidney cortex 10
thoracic aorta 10
kidney medulla 9
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 300 100.00 Very High Very High Very High
Nerve growth factor 265 100.00 Very High Very High Very High
Pain 189 100.00 Very High Very High Very High
Opioid 44 100.00 Very High Very High Very High
Central nervous system 29 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
Catecholamine 10 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Intracerebroventricular 12 99.98 Very High Very High Very High
intrathecal 8 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 158 100.00 Very High Very High Very High
Pain 154 100.00 Very High Very High Very High
Natriuresis 38 100.00 Very High Very High Very High
Reprotox - General 1 17 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 14 100.00 Very High Very High Very High
Pressure And Volume Under Development 91 99.96 Very High Very High Very High
Cv Unclassified Under Development 42 99.96 Very High Very High Very High
Pancreatic Cancer 3 99.86 Very High Very High Very High
Diabetes Mellitus 5507 99.84 Very High Very High Very High
Headache 25 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined whether endothelin-1 (ET-1), a potent vasoconstrictive peptide secreted in high concentration by metastatic prostate cancer cells, produces endothelin receptor-dependent pain behavior when applied to rat sciatic nerve.
Gene_expression (produces) of ET-1 in sciatic nerve associated with pain, sciatic nerve and reprotox - general 1
1) Confidence 0.78 Published 1998 Journal Neuroreport Section Abstract Doc Link 9694215 Disease Relevance 0.35 Pain Relevance 0.55
Recently a histological study has demonstrated that intrastriatally injected endothelin-1 (ET-1) produced ischemia-like lesions in the neostriatum.
Gene_expression (produced) of endothelin-1 associated with ischemia
2) Confidence 0.78 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1725375 Disease Relevance 0.18 Pain Relevance 0.19
The present study was undertaken to investigate whether intrastriatally injected ET-1 produces ischemic responses such as a decrease in the striatal blood flow and increases in extracellular lactate and dopamine levels in the neostriatum as seen in other models of ischemia.
Gene_expression (produces) of ET-1 in blood associated with dopamine and ischemia
3) Confidence 0.78 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1725375 Disease Relevance 0.19 Pain Relevance 0.21
Recently a histological study has demonstrated that intrastriatally injected endothelin-1 (ET-1) produced ischemia-like lesions in the neostriatum.
Gene_expression (produced) of ET-1 associated with ischemia
4) Confidence 0.78 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1725375 Disease Relevance 0.18 Pain Relevance 0.19
In addition to spontaneous nociceptive behaviors, ET-1 produced mechanical allodynia in all ages.
Gene_expression (produced) of ET-1 associated with nociception and allodynia
5) Confidence 0.78 Published 2007 Journal J Pain Section Abstract Doc Link 17553749 Disease Relevance 1.09 Pain Relevance 0.32
This study investigates changes in blood flow to the pancreas and other abdominal organs in a rat model of CP and compares ET-1 production in the pancreata of these rats and normal controls.
Gene_expression (production) of ET-1 in blood associated with chronic pancreatitis
6) Confidence 0.78 Published 1996 Journal Pancreas Section Abstract Doc Link 8783339 Disease Relevance 0.99 Pain Relevance 0.70
The results suggest that elevation in local production of ET-1 may be associated with the morphological and hemodynamic changes of CP.
Gene_expression (production) of ET-1 associated with chronic pancreatitis
7) Confidence 0.78 Published 1996 Journal Pancreas Section Abstract Doc Link 8783339 Disease Relevance 0.44 Pain Relevance 0.40
Alterations in pancreatic microcirculation and expression of endothelin-1 in a model of chronic pancreatitis.
Gene_expression (expression) of endothelin-1 associated with chronic pancreatitis
8) Confidence 0.78 Published 1996 Journal Pancreas Section Title Doc Link 8783339 Disease Relevance 0.99 Pain Relevance 0.71
Immunohistochemistry was used to investigate the cellular production of ET-1.
Spec (investigate) Gene_expression (production) of ET-1
9) Confidence 0.78 Published 1996 Journal Pancreas Section Abstract Doc Link 8783339 Disease Relevance 0.98 Pain Relevance 0.71
Centrally administered endothelin-1 (ET-1) produces a biphasic response, an initial increase followed by a decrease in blood pressure (BP).
Gene_expression (produces) of ET-1 in blood associated with pressure volume 2 under development
10) Confidence 0.78 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321804 Disease Relevance 0.31 Pain Relevance 0.04
Centrally administered endothelin-1 (ET-1) produces a biphasic response, an initial increase followed by a decrease in blood pressure (BP).
Gene_expression (produces) of endothelin-1 in blood associated with pressure volume 2 under development
11) Confidence 0.78 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321804 Disease Relevance 0.31 Pain Relevance 0.04
Expression of endothelin-1 in pancreatic tissue of patients with chronic pancreatitis.
Gene_expression (Expression) of endothelin-1 associated with chronic pancreatitis
12) Confidence 0.77 Published 1996 Journal J. Pathol. Section Title Doc Link 8778321 Disease Relevance 0.82 Pain Relevance 0.59
Endothelin-1 mRNA was expressed in sites similar to those of the immunostaining, as well as in vascular endothelial cells.
Gene_expression (expressed) of Endothelin-1 mRNA in endothelial cells
13) Confidence 0.77 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8778321 Disease Relevance 0.71 Pain Relevance 0.67
The aim of this study was to investigate sites of endothelin-1 expression in the pancreas of normal subjects and patients with chronic pancreatitis.
Gene_expression (expression) of endothelin-1 in pancreas associated with chronic pancreatitis
14) Confidence 0.77 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8778321 Disease Relevance 0.85 Pain Relevance 0.60
Northern blot analysis showed an increase in the expression of endothelin-1 mRNA in the patient population.
Gene_expression (expression) of endothelin-1 mRNA
15) Confidence 0.77 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8778321 Disease Relevance 0.64 Pain Relevance 0.64
These findings suggest that an elevation in local expression of endothelin-1 may be associated with the morphological and haemodynamic changes of chronic pancreatitis.
Gene_expression (expression) of endothelin-1 associated with chronic pancreatitis
16) Confidence 0.77 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8778321 Disease Relevance 0.55 Pain Relevance 0.58
Unlike intravenous administration, intrathecal endothelin-1 and endothelin-3 produced indistinguishable effects on arterial pressure, heart rate, renal sympathetic nerve activity, spinal blood flow, and spinal vascular resistance, suggesting that the spinal neuronal endothelin receptors may be less selective than those in the blood vessels.
Gene_expression (produced) of endothelin-1 in spinal associated with intrathecal
17) Confidence 0.77 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 2035687 Disease Relevance 0.50 Pain Relevance 0.24
We showed previously that subcutaneous injection of the injury-associated peptide mediator endothelin-1 (ET-1) into the rat plantar hindpaw produces pain behavior and selective excitation of nociceptors, both through activation of ET(A) receptors likely on nociceptive terminals.
Gene_expression (produces) of ET-1 in nociceptors associated with nociception, pain, nociceptor and injury
18) Confidence 0.77 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12196602 Disease Relevance 0.37 Pain Relevance 0.53
These include effects of SMN and CGRP against endogenously produced ET-1 in other vessels and other species.
Gene_expression (produced) of ET-1 in vessels associated with calcitonin gene-related peptide
19) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0.36 Pain Relevance 0.62
Inhibitors of endothelin (ET), which is a potent vasoconstrictor produced in the vascular endothelium, may also improve pulmonary hypertension.
Gene_expression (produced) of endothelin in vascular endothelium associated with hypertension
20) Confidence 0.75 Published 2009 Journal Pediatr Surg Int Section Body Doc Link PMC2734260 Disease Relevance 1.08 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox