INT5782

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 3.38
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn3) extracellular region (Edn3) cellular_component (Edn3)
Anatomy Link Frequency
blood 2
spinal 1
endothelial cells 1
spinal cord 1
neurons 1
Edn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 23 99.96 Very High Very High Very High
intrathecal 8 99.64 Very High Very High Very High
antagonist 58 99.36 Very High Very High Very High
Spinal cord 15 98.72 Very High Very High Very High
dopamine receptor 2 98.68 Very High Very High Very High
Pain 7 98.32 Very High Very High Very High
Inflammation 31 97.92 Very High Very High Very High
agonist 33 97.80 Very High Very High Very High
nociceptor 6 97.28 Very High Very High Very High
Glutamate 15 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 4 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 15 99.64 Very High Very High Very High
Cancer 23 98.52 Very High Very High Very High
INFLAMMATION 32 97.92 Very High Very High Very High
Heart Rate Under Development 9 96.48 Very High Very High Very High
Pain 6 95.52 Very High Very High Very High
Hyperalgesia 5 90.28 High High
Pressure And Volume Under Development 3 88.88 High High
Cv Unclassified Under Development 15 88.20 High High
Osteoporosis 20 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possible involvement that the pressor and positive chronotropic effects of endothelin-3 (ET-3) administered intracerebroventricularly (i.c.v.) participate in the central beta-adrenoceptor has been studied in urethane anesthetized rats.
Gene_expression (participate) of ET-3
1) Confidence 0.67 Published 1995 Journal Life Sci. Section Abstract Doc Link 7603307 Disease Relevance 0.09 Pain Relevance 0.03
Possible involvement that the pressor and positive chronotropic effects of endothelin-3 (ET-3) administered intracerebroventricularly (i.c.v.) participate in the central beta-adrenoceptor has been studied in urethane anesthetized rats.
Gene_expression (participate) of endothelin-3
2) Confidence 0.67 Published 1995 Journal Life Sci. Section Abstract Doc Link 7603307 Disease Relevance 0.09 Pain Relevance 0.03
Based on these results, we hypothesize that endothelin-3 produces dopamine release through two distinct mechanisms; one is a direct stimulation of dopaminergic nerve terminals and the other was activation of interneurons which promoted the release of glutamate, resulting in dopamine release.
Gene_expression (produces) of endothelin-3 in interneurons associated with glutamate and dopamine
3) Confidence 0.67 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957613 Disease Relevance 0 Pain Relevance 0.95
In the isolated tissue with no precontraction ET-1 and ET-3 were potent spasmogens which produced half maximal contractions at concentrations 4.5 and 8.0 nM, respectively.
Gene_expression (produced) of ET-3
4) Confidence 0.63 Published 1992 Journal Regul. Pept. Section Abstract Doc Link 1315978 Disease Relevance 0 Pain Relevance 0.13
Intrathecal administration of endothelin-3 produces hypotension in anesthetized rats.
Gene_expression (produces) of endothelin-3 associated with pressure volume 2 under development and intrathecal
5) Confidence 0.60 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7982458 Disease Relevance 0.31 Pain Relevance 0.14
Unlike intravenous administration, intrathecal endothelin-1 and endothelin-3 produced indistinguishable effects on arterial pressure, heart rate, renal sympathetic nerve activity, spinal blood flow, and spinal vascular resistance, suggesting that the spinal neuronal endothelin receptors may be less selective than those in the blood vessels.
Gene_expression (produced) of endothelin-3 in spinal associated with intrathecal
6) Confidence 0.47 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 2035687 Disease Relevance 0.50 Pain Relevance 0.24
In conscious rats, the intrathecal (i.t.) injection of endothelin-1 (ET-1; 65-650 pmol) and endothelin-3 (ET-3; 162-650 pmol) produced dose-dependent increases of mean arterial blood pressure (MAP) accompanied by either a tachycardia or a bradycardia.
Gene_expression (produced) of endothelin-3 in blood associated with heart rate under development and intrathecal
7) Confidence 0.46 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522926 Disease Relevance 0.19 Pain Relevance 0.15
In conscious rats, the intrathecal (i.t.) injection of endothelin-1 (ET-1; 65-650 pmol) and endothelin-3 (ET-3; 162-650 pmol) produced dose-dependent increases of mean arterial blood pressure (MAP) accompanied by either a tachycardia or a bradycardia.
Gene_expression (produced) of ET-3 in blood associated with heart rate under development and intrathecal
8) Confidence 0.46 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522926 Disease Relevance 0.19 Pain Relevance 0.15
Small intestines are the major source of ET-3 production [15].
Gene_expression (production) of ET-3 in Small intestines
9) Confidence 0.33 Published 2006 Journal World J Emerg Surg Section Body Doc Link PMC1764411 Disease Relevance 0.29 Pain Relevance 0.09
In rat spinal cord slices, endothelin-1 and endothelin-3 enhanced [3H]inositol phosphate production between 1 nM and 10 microM (endothelin-1 > endothelin-3) while sarafotoxin 6c and the endothelin ETB receptor agonist IRL-1620 (Suc-[Glu9,Ala11,15]endothelin-1-(8-21)) were almost ineffective.
Gene_expression (production) of endothelin-3 in spinal cord associated with agonist and spinal cord
10) Confidence 0.26 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8982672 Disease Relevance 0 Pain Relevance 0.18
BQ-123 (cyclo(D-Trp,D-Asp,L-Pro,D-Val,L-Leu), a selective endothelin ETA receptor antagonist, reduced the endothelin-1- and endothelin-3-induced [3H]inositol phosphate production, with similar inhibition constants (IC50: 16.7 +/- 3.4 and 8.0 +/- 1.6 microM, respectively).
Gene_expression (production) of endothelin-3-induced associated with antagonist
11) Confidence 0.26 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8982672 Disease Relevance 0 Pain Relevance 0.21
ET-3 (0.1-300 pmol) produced only dose-dependent increases in hindquarter perfusion pressure.
Gene_expression (produced) of ET-3
12) Confidence 0.23 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2260707 Disease Relevance 0.15 Pain Relevance 0
ET-1 and ET-3-like immunoreactivity and ET-R are expressed in the anterior pituitary (261–263), more precisely in lactotrophs (396, 397).
Gene_expression (expressed) of ET-3 in lactotrophs
13) Confidence 0.22 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0.43
Considering 100% cross reactions of this kit for all ET subtypes including ET-1, ET-2 and ET-3 and performing our analysis without prior purification process it should be addressed that our measurements reflects total endothelin measurements, not ET-1 alone.
Gene_expression (subtypes) of ET-3
14) Confidence 0.09 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.28 Pain Relevance 0
Endothelin-1 is synthesized within the endothelium of cerebral vessels, whereas both endothelin-1 and endothelin-3 in addition have been identified in neurons and glia.
Gene_expression (synthesized) of endothelin-3 in neurons
15) Confidence 0.08 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7954753 Disease Relevance 0.31 Pain Relevance 0
The endothelins, ET-1, ET-2 and ET-3, are vasoactive peptides, originally cloned from endothelial cells [1], but also produced by other cell types, including some tumor cells [2-5].
Gene_expression (produced) of ET-3 in endothelial cells associated with cancer
16) Confidence 0.05 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.72 Pain Relevance 0.76
The unexpected absence of an ET-1-mediated depressor response but the presence of ET-3 and S6c vasodilation in this species supports the theory that there may be subtypes of the ET(B) receptor.
Gene_expression (presence) of ET-3 associated with increased venous pressure under development
17) Confidence 0.05 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10470993 Disease Relevance 0.18 Pain Relevance 0.18

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