INT57842

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Context Info
Confidence 0.03
First Reported 1993
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrng)
Anatomy Link Frequency
NG108-15 2
cortex 2
Chrng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 100.00 Very High Very High Very High
Delta opioid receptors 1 92.44 High High
medulla 5 91.16 High High
Physical dependence 1 88.56 High High
midbrain 3 88.12 High High
tolerance 1 87.56 High High
Potency 1 87.28 High High
Opioid 1 84.84 Quite High
opioid receptor 1 66.32 Quite High
Neurobehavioral 1 55.28 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 88.56 High High
Poisoning 1 87.12 High High
Bordatella Infection 1 74.72 Quite High
Chronic Fatigue Syndrome 1 25.00 Low Low
Headache 1 25.00 Low Low
Ataxia 1 25.00 Low Low
Arthralgia 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report that long-term (2 days) treatment of NG108-15 cells with ethanol increased the binding of the alpha 2-adrenergic receptor (alpha 2AR) antagonist [3H]rauwolscine and the muscarinic acetylcholine receptor (mAChR) antagonist [3H]quinuclidinyl benzilate by 2.8- and 1.4-fold, respectively.
Positive_regulation (increased) of mAChR Binding (binding) of in NG108-15 associated with antagonist
1) Confidence 0.03 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8226869 Disease Relevance 0.25 Pain Relevance 0.40
Treatment with PB, DEET, and permethrin alone caused a significant increase in ligand binding for m2 muscarinic acetylcholine receptor (mAChR) in the cortex.
Positive_regulation (increase) of mAChR Binding (binding) of in cortex
2) Confidence 0.02 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11248143 Disease Relevance 0 Pain Relevance 0.35

General Comments

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