INT57852

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 1.02
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
plasma 1
testis 1
arcuate nucleus 1
somatotropes 1
pituitary 1
Ghsr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 9 99.96 Very High Very High Very High
Clonidine 2 98.44 Very High Very High Very High
antagonist 6 98.20 Very High Very High Very High
Enkephalin 8 95.00 High High
Potency 4 94.68 High High
Sumatriptan 1 77.36 Quite High
Serotonin 1 76.20 Quite High
Morphine 1 75.16 Quite High
isoflurane 1 73.44 Quite High
anesthesia 3 73.00 Quite High
Disease Link Frequency Relevance Heat
Ileus 4 97.28 Very High Very High Very High
Growth Hormone Deficiency 4 96.52 Very High Very High Very High
Aids-related Complex 14 96.00 Very High Very High Very High
Hypoglycemia 1 96.00 Very High Very High Very High
Targeted Disruption 1 76.64 Quite High
Body Weight 16 69.52 Quite High
Hyperplasia 35 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Reprotox - General 3 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of photoperiod on Ghrelin and GHSR-1a in the adult Soay testis
Regulation (Effect) of GHSR in testis
1) Confidence 0.59 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus.
Regulation (Effect) of ghrelin receptor associated with ileus and agonist
2) Confidence 0.44 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19121631 Disease Relevance 0.26 Pain Relevance 0.28
Although the effects on ACTH have recently been studied, there is little information about the effects of GHRP-6 on PRL.
Regulation (effects) of GHRP-6
3) Confidence 0.41 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor.
Regulation (using) of GHRP associated with antagonist
4) Confidence 0.40 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9849822 Disease Relevance 0 Pain Relevance 0.20
Ghrelin receptor (GHSR-1a) and PCNA immunoreactivity were detected using the Vectastain Elite ABC kit (Vector Laboratories Ltd, Peterborough, UK) The protocol was as described above with exception of the following: the secondary antibody was a biotinylated rabbit anti-goat IgG (Vector Laboratories Ltd, Peterborough, UK) in a 1:200 dilution.
Regulation (immunoreactivity) of GHSR
5) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
In the anterior pituitary gland, ghrelin and GHSR-1a immunoreactivity was also present, with GHSR-1a showing cytoplasmic and perinuclear staining in some cells (Fig. 1) In the adult ovary, ghrelin and GHSR-1a were immuno-localised to ovarian follicles at all developmental stages (primordial, primary, secondary, pre-antral and antral).
Regulation (immunoreactivity) of GHSR in adult ovary
6) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.08 Pain Relevance 0
In the sheep brain, ghrelin and GHSR-1a immunoreactivity were demonstrated in the hypothalamic region, including the median eminence (ME), arcuate nucleus (ARC), ventromedial hypothalamus (VMH) and ependymal lining (EL) of the third cerebral ventricle.
Regulation (immunoreactivity) of GHSR in arcuate nucleus associated with aids-related complex
7) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.10 Pain Relevance 0
Novel data are presented that indicate that ghrelin and its functional receptor, GHSR-1a, are regulated during development of the ovine fetal testis and by seasonal developmental changes in the adult testis.
Regulation (regulated) of GHSR in adult testis
8) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.06 Pain Relevance 0
Ghrelin receptor (GHSR-1a) and PCNA immunoreactivity were detected using the Vectastain Elite ABC kit (Vector Laboratories Ltd, Peterborough, UK) The protocol was as described above with exception of the following: the secondary antibody was a biotinylated rabbit anti-goat IgG (Vector Laboratories Ltd, Peterborough, UK) in a 1:200 dilution.
Regulation (immunoreactivity) of Ghrelin receptor
9) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
In order to evaluate GHRP-6 as a test of pituitary GH reserve, we studied GH responses of i.v. administered GHRP-6 in a group of short-statured children, as well as in a group of adults diagnosed with growth hormone deficiency (GHD) by conventional GH testing.
Regulation (responses) of GHRP-6 in pituitary associated with growth hormone deficiency
10) Confidence 0.17 Published 1996 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 8887178 Disease Relevance 0.37 Pain Relevance 0.10
These results suggest that the sensitivity of the GHS-R in the gastrointestinal tract might be inhibited by low intragastric pH.

5.

Regulation (sensitivity) of GHS-R
11) Confidence 0.13 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0.15 Pain Relevance 0
In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH).
Regulation (effects) of GHRP-6 in somatotropes
12) Confidence 0.12 Published 1999 Journal J. Physiol. Biochem. Section Abstract Doc Link 10494658 Disease Relevance 0 Pain Relevance 0.10
The present study provides immunohistochemical evidence for the presence of ghrelin and its functional receptor, growth hormone secretagogue receptor (GHSR-1a), in reproductive tissues of the sheep.
Regulation (presence) of growth hormone secretagogue receptor
13) Confidence 0.11 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
On the other hand, administration of the alpha-2 adrenergic agonist clonidine (4 micrograms/kg i.v.) increased basal plasma GH levels without affecting GH responses to GHRP-6.
Regulation (responses) of GHRP-6 in plasma associated with agonist and clonidine
14) Confidence 0.04 Published 1993 Journal J. Endocrinol. Section Abstract Doc Link 8228729 Disease Relevance 0 Pain Relevance 0.19
It also strongly reduced, but did not abolish the effect of the two peptides (GHRH plus GHRP-6) administered together.
Regulation (effect) of GHRP-6
15) Confidence 0.02 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11598377 Disease Relevance 0 Pain Relevance 0.24

General Comments

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