INT57874

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 113
Total Number 114
Disease Relevance 68.46
Pain Relevance 24.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
hippocampus 5
nerve 5
brain 4
eyes 3
striatum 3
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 267 100.00 Very High Very High Very High
Anterior cingulate cortex 28 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Hippocampus 258 99.96 Very High Very High Very High
cINOD 35 99.92 Very High Very High Very High
long-term potentiation 185 99.90 Very High Very High Very High
Inflammation 296 99.78 Very High Very High Very High
cocaine 50 99.78 Very High Very High Very High
fluoxetine 24 99.62 Very High Very High Very High
Pyramidal cell 37 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 816 100.00 Very High Very High Very High
Aids-related Complex 88 100.00 Very High Very High Very High
Cold Sores 2 99.84 Very High Very High Very High
Targeted Disruption 586 99.80 Very High Very High Very High
Myopia 191 99.80 Very High Very High Very High
INFLAMMATION 372 99.78 Very High Very High Very High
Convulsion 89 99.68 Very High Very High Very High
Adenocarcinoma 9 99.64 Very High Very High Very High
Hemorrhagic Shock 78 99.56 Very High Very High Very High
Inflammatory Pain 14 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Egr1 knockout mice showed reduced nociceptive behaviors to persistent inflammatory pain and inflammation increased Egr1 expression in the anterior cingulate cortex of wild-type mice.
Gene_expression (expression) of Egr1 in anterior associated with nociception, targeted disruption, inflammation, ipn and anterior cingulate cortex
1) Confidence 0.78 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 1.46 Pain Relevance 0.86
Expression of Egr1, as well as other immediate early genes, is up-regulated in response to a number of noxious stimuli.
Gene_expression (Expression) of Egr1
2) Confidence 0.78 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 0.48 Pain Relevance 0.25
In addition, inflammation triggered an up-regulation of Egr1 expression in the ACC of wild-type mice.
Gene_expression (expression) of Egr1 in ACC associated with inflammation and anterior cingulate cortex
3) Confidence 0.78 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 1.36 Pain Relevance 0.75
The Egr-1 mRNA expression diminished after 4 h of resuscitation, whereas Egr-1 protein expression and DNA binding activity persisted through resuscitation.
Gene_expression (expression) of Egr-1
4) Confidence 0.78 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.34 Pain Relevance 0.24
Northern blot analysis was performed to evaluate Egr-1 messenger RNA (mRNA) expression.
Gene_expression (expression) of Egr-1 messenger RNA
5) Confidence 0.78 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.49 Pain Relevance 0.21
Liver whole cell lysates were evaluated for Egr-1 protein expression by Western blot analysis.
Gene_expression (expression) of Egr-1 in Liver
6) Confidence 0.78 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.45 Pain Relevance 0.20
We hypothesized that HS would induce hepatic expression of Egr-1 and that Egr-1 upregulates the inflammatory response after HS.
Gene_expression (expression) of Egr-1 associated with inflammatory response and hemorrhagic shock
7) Confidence 0.78 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.47 Pain Relevance 0.21
Egr2 mRNA and protein have been detected in several areas of the neocortex, hippocampus, amygdala, olfactory bulb, striatum, cerebellum, diencephalic and brainstem structures, although its expression is generally weaker than that of Egr1 (reviewed in Beckmann and Wilce, 1997).
Gene_expression (expression) of Egr1 in brainstem associated with medulla, hippocampus and amygdala
8) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.26
Numerous studies over the past several years have shown that the expression of Egr1 is rapidly induced in defined brain structures after specific learning experiences or exposure to learning-associated events (e.g.
Gene_expression (expression) of Egr1 in brain structures
9) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.14
Thus, it is possible that Egr2, which seems expressed at lower levels than Egr1 and Egr3 in most brain regions as confirmed here in the dentate gyrus and area CA1 of the hippocampus, is not, or is less responsive to physiological neuronal activity during learning and is therefore dispensable for learning and memory.
Gene_expression (expressed) of Egr1 in neuronal associated with hippocampus
10) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.32 Pain Relevance 0.23
We found no change in basal, constitutive levels of Egr1 or Egr3 protein expression, or in seizure-induced expression, in either area CA1 of the hippocampus or the dentate gyrus in cKO or HT mice, indicating that at least in hippocampal regions the absence of one or two Egr2 alleles is not associated with overexpression of these other Egr family members.
Gene_expression (overexpression) of Egr in hippocampus associated with convulsion and hippocampus
11) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.67 Pain Relevance 0.27
Another Egr family member expressed in brain, Egr2/Krox20 is known to be crucial for normal hindbrain development and has been implicated in several inherited peripheral neuropathies; however, due to Egr2-null mice perinatal lethality, its potential role in cognitive functions in the adult has not been yet explored.
Gene_expression (expressed) of Egr in hindbrain associated with cognitive disorder and peripheral neuropathy
12) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Abstract Doc Link PMC2525857 Disease Relevance 0.24 Pain Relevance 0
In the hippocampus, both Egr1 and Egr2 are highly expressed in CA1-3 pyramidal cells, with negligible basal levels in granule cells of the dentate gyrus (Herdegen et al., 1993; Mack et al., 1990; Yamagata et al., 1994).
Gene_expression (expressed) of Egr1 in pyramidal cells associated with pyramidal cell and hippocampus
13) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.21 Pain Relevance 0.26
Like other Egr members, Egr2 can be induced in brain by various stimuli, including electroconvulsive shock inducing seizure activity (Bhat et al., 1992, this study), focal cerebral ischaemia (An et al., 1992), dopamine receptor activation and opiate withdrawal (Bhat et al., 1992) and in hippocampal neurons following kainic acid injection (Gass et al., 1994) or LTP-inducing stimuli (Williams et al., 1995), although Egr2 is less robustly induced and is not induced by weaker patterns of stimuli despite induction of long-lasting LTP along with Egr1 expression (Worley et al., 1993).
Gene_expression (expression) of Egr1 in brain associated with brain hemorrhage, convulsion, dopamine receptor, shock, long-term potentiation, opiate and withdrawal
14) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.42 Pain Relevance 0.32
In dentate gyrus of the hippocampus, Egr1 is rapidly expressed after induction of long-term potentiation (LTP), an activity-dependent form of synaptic plasticity believed to play a crucial role in the formation of memories, and its regulated expression is closely linked to the persistence of LTP (Abraham et al., 1991; Abraham et al., 1993; Richardson et al., 1992; Worley et al., 1993).
Gene_expression (expressed) of Egr1 in dentate gyrus associated with long-term potentiation and hippocampus
15) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.23
We found no change in basal, constitutive levels of Egr1 or Egr3 protein expression, or in seizure-induced expression, in either area CA1 of the hippocampus or the dentate gyrus in cKO or HT mice, indicating that at least in hippocampal regions the absence of one or two Egr2 alleles is not associated with overexpression of these other Egr family members.
Gene_expression (expression) of Egr1 in hippocampus associated with convulsion and hippocampus
16) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.67 Pain Relevance 0.17
In Schwann cells, for example, Egr1 and Egr2 are expressed in a successive and mutually exclusive manner during embryogenesis and examination of their role in myelination has suggested that they might compete and possibly repress each other (Topilko et al., 1997).
Gene_expression (expressed) of Egr1 in Schwann cells
17) Confidence 0.77 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.19 Pain Relevance 0
In a similar vein, BDNF and zif268 mRNA expression were reported in the entorhinal and prefrontal cortices after object sampling, while in this experiment reactivation 9 days after training induced zif268 in entorhinal and somatosensory cortices and upon reactivation 21 days after training, BDNF and not zif268 was expressed in hippocampus and entorhinal and somatosensory cortices (Romero-Granados et al., 2010).
Neg (not) Gene_expression (expressed) of zif268 in vein associated with hippocampus
18) Confidence 0.76 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0 Pain Relevance 0.05
The impact of diffuser and ND filter treatment on Egr-1 and cFos mRNA expression was analyzed over time and also compared to a group of untreated control animals (Figure 3).
Gene_expression (expression) of Egr-1
19) Confidence 0.76 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.07 Pain Relevance 0
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Gene_expression (selected) of Egr-1 in finger associated with osteogenic sarcomas
20) Confidence 0.76 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox