INT57876

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 46
Total Number 51
Disease Relevance 25.60
Pain Relevance 9.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
neural 6
lens 3
macrophage 2
dentate gyrus 2
striatum 2
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
Nerve growth factor 103 99.98 Very High Very High Very High
cocaine 29 99.84 Very High Very High Very High
Anterior cingulate cortex 58 99.68 Very High Very High Very High
Dopamine 24 99.42 Very High Very High Very High
cytokine 69 99.40 Very High Very High Very High
GABAergic 2 99.08 Very High Very High Very High
Hippocampus 220 98.84 Very High Very High Very High
substance P 9 98.80 Very High Very High Very High
Inflammation 273 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 2 100.00 Very High Very High Very High
Glioma 2 100.00 Very High Very High Very High
Vasculitis 528 99.84 Very High Very High Very High
Apoptosis 50 99.48 Very High Very High Very High
Shock 199 99.32 Very High Very High Very High
Systemic Lupus Erythematosus 72 99.32 Very High Very High Very High
Hypoxia 22 99.20 Very High Very High Very High
Stress 41 98.96 Very High Very High Very High
Injury 197 98.82 Very High Very High Very High
Increased Venous Pressure Under Development 38 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activity-dependent activation of Egr1 has been reported in forebrain regions, including the anterior cingulate cortex (ACC), after peripheral injury.
Positive_regulation (activation) of Egr1 in cingulate cortex associated with injury and anterior cingulate cortex
1) Confidence 0.70 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 0.61 Pain Relevance 0.34
In a similar vein, BDNF and zif268 mRNA expression were reported in the entorhinal and prefrontal cortices after object sampling, while in this experiment reactivation 9 days after training induced zif268 in entorhinal and somatosensory cortices and upon reactivation 21 days after training, BDNF and not zif268 was expressed in hippocampus and entorhinal and somatosensory cortices (Romero-Granados et al., 2010).
Positive_regulation (induced) of zif268 in vein associated with hippocampus
2) Confidence 0.68 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0 Pain Relevance 0.05
Zif268 protein is rapidly induced in the dentate gyrus of the hippocampus after object sampling (Soulé et al., 2008) and in mutant mice a gene-dosage effect was found as half the complement of zif268 in heterozygous mutant mice resulted in deficits in long-term object-location memory without impairment in novel object recognition (Bozon et al., 2002).
Positive_regulation (induced) of Zif268 protein in dentate gyrus associated with cognitive disorder, eae and hippocampus
3) Confidence 0.68 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.33 Pain Relevance 0.14
These data suggest a biological scenario and rationale in which the developing mouse tumor secretes NGF into the circulation, where it circulates in the blood to the salivary glands and binds to NGF receptors expressed by salivary acinar cells, activating a signaling pathway that leads to the upregulation of Egr-1 mRNA and protein levels.
Positive_regulation (upregulation) of Egr-1 mRNA in acinar cells associated with nerve growth factor, salivary gland disease and cancer
4) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.28 Pain Relevance 0.36
In these animals, cocaine failed to induce the immediate-early genes c-fos and zif 268.
Neg (failed) Positive_regulation (induce) of zif 268 associated with cocaine
5) Confidence 0.67 Published 1996 Journal Neuroscience Section Abstract Doc Link 8884777 Disease Relevance 0 Pain Relevance 0.55
We used the Min mouse model to determine if sulindac sulfide would increase Egr-1 and TSP-1 in vivo, because this model is widely used to study the effects of NSAIDs on tumor formation.
Spec (determine) Positive_regulation (increase) of Egr-1 associated with cancer and cinod
6) Confidence 0.66 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.59 Pain Relevance 0.38
Interestingly, the induction of immediate early genes c-Fos and Egr-1 which can function as sensors for duration of Erk1/2 signaling [20] was reduced in c-Met mutant mice, particularly at the later time points of liver regeneration (Figure S3).
Positive_regulation (induction) of Egr-1 in liver
7) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.05 Pain Relevance 0
Some of the early events—for example, ZENK expression changes—may persist after one day of lens treatment (ZENK mRNA level remains low after one day of negative lens treatment) or even reverse the direction of changes (ZENK mRNA levels are upregulated by short periods of positive lens wear [19] but seem to be downregulated by longer periods of positive lens treatment [41]).
Positive_regulation (upregulated) of ZENK in lens
8) Confidence 0.54 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Positive_regulation (named) of Krox24 in neural
9) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Positive_regulation (named) of Zif268 in neural
10) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Positive_regulation (named) of Egr1 in neural
11) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Positive_regulation (named) of TIS8 in neural
12) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0
The first evidence that an object recognition memory can undergo reconsolidation after recall came from two experiments that examined what happens after a recall test in conditions of blocking MAPK/ERK activation or of inactivating zif268.
Positive_regulation (inactivating) of zif268 associated with cognitive disorder
13) Confidence 0.49 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.64 Pain Relevance 0.06
Similar results were obtained in zif268 mutant mice showing that zif268 is required for the consolidation of both object and object-location recognition memory (Jones et al., 2001).
Positive_regulation (required) of zif268
14) Confidence 0.49 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.30 Pain Relevance 0.12
In the macaque retina it was shown that focus-sensitive immunoreactivity for Egr-1 is induced in a subpopulation of GABAergic amacrine cells (GAD65-immunoreactive cells) [22].


Positive_regulation (induced) of Egr-1 in amacrine cells associated with gabaergic
15) Confidence 0.49 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.17 Pain Relevance 0.05
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Positive_regulation (named) of immediate early growth response-1 in neural
16) Confidence 0.49 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0
The present study used two inbred strains of mice that differ in their behavioral responsiveness to stress (Balb/c and C57Bl/6), exposed them to an established paradigm of early life stress (infant maternal separation), and measured their expression of frontal cortical and hippocampal GRs and the putative transcriptional activator of the GR gene, early growth response gene (egr)-1, at defined stages of postnatal development.
Positive_regulation (activator) of early growth response gene associated with stress and sprains and strains
17) Confidence 0.48 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.11 Pain Relevance 0.14
Our Western blot analyses also suggest that the normal performance of Egr2-deficient mice and the facilitation observed in certain tasks is not due to a compensatory overexpression, or a greater inducibility of the Egr family members known to be involved in learning and memory.
Positive_regulation (inducibility) of Egr
18) Confidence 0.46 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.70 Pain Relevance 0.04
In contrast, Egr1 proteins were upregulated following MECS in all groups (t-test, all p values <0.01) with no difference in the level of regulation between genotypes (F?
Positive_regulation ( were upreg) of Egr1 associated with shock
19) Confidence 0.46 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.53 Pain Relevance 0.04
Also in keeping with the pattern of results observed in the dentate gyrus, there was significant induction of Egr1 in all genotypes following MECS compared with non-stimulated mice (t-test, all p values <0.05; Figures 7A and 7D), and no significant regulation of Egr3 at this time point (t-test, all p values >0.05; Figures 7C and 7D).
Positive_regulation (induction) of Egr1 in dentate gyrus associated with shock
20) Confidence 0.46 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.62 Pain Relevance 0.04

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