INT57877

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.63
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
liver 2
endothelial cell 2
striatum 2
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 8 98.68 Very High Very High Very High
fluoxetine 2 94.48 High High
Desipramine 1 92.28 High High
Inflammation 1 92.16 High High
Dopamine 6 84.12 Quite High
cINOD 8 79.40 Quite High
monoamine 1 78.48 Quite High
Serotonin 2 75.00 Quite High
Hippocampus 25 61.64 Quite High
agonist 1 58.92 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 1 99.20 Very High Very High Very High
Cognitive Disorder 21 97.22 Very High Very High Very High
INFLAMMATION 2 92.16 High High
Apoptosis 3 90.48 High High
Neurodegenerative Disease 4 88.40 High High
Cancer 5 75.80 Quite High
Ulcers 3 70.52 Quite High
Targeted Disruption 17 59.60 Quite High
Colon Cancer 1 58.60 Quite High
Cardiovascular Disease 1 57.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first evidence that an object recognition memory can undergo reconsolidation after recall came from two experiments that examined what happens after a recall test in conditions of blocking MAPK/ERK activation or of inactivating zif268.
Negative_regulation (blocking) of Positive_regulation (inactivating) of zif268 associated with cognitive disorder
1) Confidence 0.42 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.65 Pain Relevance 0.06
Interestingly, the induction of immediate early genes c-Fos and Egr-1 which can function as sensors for duration of Erk1/2 signaling [20] was reduced in c-Met mutant mice, particularly at the later time points of liver regeneration (Figure S3).
Negative_regulation (reduced) of Positive_regulation (induction) of Egr-1 in liver
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.06 Pain Relevance 0
Furthermore, selective denervation of 5-HT projections by p-chloroamphetamine treatment attenuated the increase in zif268 and c-fos expression induced by cocaine in the striatum.
Negative_regulation (attenuated) of Positive_regulation (increase) of zif268 in striatum associated with cocaine
3) Confidence 0.37 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229780 Disease Relevance 0 Pain Relevance 0.86
Some of these mechanisms include: inhibition of mitogen-activated protein (Erk2) kinase activity; suppression of cell cycle proteins; inhibition of early growth response (Egr-1) gene activation; interference with hypoxia inducible factor 1 and VEGF gene activation; increased production of the angiogenesis inhibitor, endostatin; inhibition of endothelial cell proliferation, migration, and spreading; and induction of endothelial apoptosis.
Negative_regulation (inhibition) of Positive_regulation (activation) of Egr-1 in endothelial cell associated with hypoxia and apoptosis
4) Confidence 0.04 Published 2003 Journal J. Mol. Med. Section Abstract Doc Link 13679997 Disease Relevance 0.92 Pain Relevance 0.66

General Comments

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