INT57878

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 36
Total Number 37
Disease Relevance 20.42
Pain Relevance 14.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
striatum 8
nerve 6
brain structures 4
Liver 2
anterior 2
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 52 100.00 Very High Very High Very High
Anterior cingulate cortex 28 100.00 Very High Very High Very High
cocaine 64 99.98 Very High Very High Very High
Inflammation 38 99.98 Very High Very High Very High
cINOD 30 99.92 Very High Very High Very High
Hippocampus 74 99.84 Very High Very High Very High
fluoxetine 20 99.80 Very High Very High Very High
IPN 14 99.64 Very High Very High Very High
long-term potentiation 47 99.50 Very High Very High Very High
Dopamine 50 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 7 100.00 Very High Very High Very High
INFLAMMATION 50 99.98 Very High Very High Very High
Hemorrhagic Shock 39 99.98 Very High Very High Very High
Cancer 160 99.84 Very High Very High Very High
Inflammatory Pain 14 99.64 Very High Very High Very High
Adenocarcinoma 6 99.64 Very High Very High Very High
Stress 29 99.22 Very High Very High Very High
Melanoma 102 99.06 Very High Very High Very High
Fibrosis 19 98.90 Very High Very High Very High
Nociception 13 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Egr1 knockout mice showed reduced nociceptive behaviors to persistent inflammatory pain and inflammation increased Egr1 expression in the anterior cingulate cortex of wild-type mice.
Positive_regulation (increased) of Gene_expression (expression) of Egr1 in anterior associated with nociception, targeted disruption, inflammation, ipn and anterior cingulate cortex
1) Confidence 0.70 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 1.46 Pain Relevance 0.87
We hypothesized that HS would induce hepatic expression of Egr-1 and that Egr-1 upregulates the inflammatory response after HS.
Positive_regulation (induce) of Gene_expression (expression) of Egr-1 associated with inflammatory response and hemorrhagic shock
2) Confidence 0.70 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.48 Pain Relevance 0.21
Numerous studies over the past several years have shown that the expression of Egr1 is rapidly induced in defined brain structures after specific learning experiences or exposure to learning-associated events (e.g.
Positive_regulation (induced) of Gene_expression (expression) of Egr1 in brain structures
3) Confidence 0.69 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.14
We found no change in basal, constitutive levels of Egr1 or Egr3 protein expression, or in seizure-induced expression, in either area CA1 of the hippocampus or the dentate gyrus in cKO or HT mice, indicating that at least in hippocampal regions the absence of one or two Egr2 alleles is not associated with overexpression of these other Egr family members.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Egr in hippocampus associated with convulsion and hippocampus
4) Confidence 0.69 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.67 Pain Relevance 0.27
Therefore, it is reasonable to propose that NGF secreted by melanoma tumor was transferred through blood and bound to its cognate receptors in the salivary gland, ultimately resulting in the stimulation of multiple TFs expression including Egr-1 (Fig. 6).
Positive_regulation (stimulation) of Gene_expression (expression) of Egr-1 in blood associated with nerve growth factor, cancer and melanoma
5) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.48 Pain Relevance 0.39
These compounds inhibited tumor cell invasion and induced Egr-1 expression in lung adenocarcinoma A549 cells.
Positive_regulation (induced) of Gene_expression (expression) of Egr-1 in A549 associated with adenocarcinoma and cancer
6) Confidence 0.66 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.53 Pain Relevance 0.27
Taken together, these findings indicate that cocaine's ability to induce striatal expression of c-fos and zif268 is mediated by its effects on both the 5-HT and DA systems.
Positive_regulation (induce) of Gene_expression (expression) of zif268 associated with dopamine and cocaine
7) Confidence 0.60 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229780 Disease Relevance 0 Pain Relevance 0.67
Furthermore, selective denervation of 5-HT projections by p-chloroamphetamine treatment attenuated the increase in zif268 and c-fos expression induced by cocaine in the striatum.
Positive_regulation (increase) of Gene_expression (expression) of zif268 in striatum associated with cocaine
8) Confidence 0.60 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229780 Disease Relevance 0 Pain Relevance 0.86
Furthermore, selective denervation of 5-HT projections by p-chloroamphetamine treatment attenuated the increase in zif268 and c-fos expression induced by cocaine in the striatum.
Positive_regulation (induced) of Gene_expression (expression) of zif268 in striatum associated with cocaine
9) Confidence 0.60 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229780 Disease Relevance 0 Pain Relevance 0.86
Expression of Egr1, as well as other immediate early genes, is up-regulated in response to a number of noxious stimuli.
Positive_regulation (up-regulated) of Gene_expression (Expression) of Egr1
10) Confidence 0.50 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 0.56 Pain Relevance 0.29
In addition, inflammation triggered an up-regulation of Egr1 expression in the ACC of wild-type mice.
Positive_regulation (up-regulation) of Gene_expression (expression) of Egr1 in ACC associated with inflammation and anterior cingulate cortex
11) Confidence 0.50 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 1.37 Pain Relevance 0.76
Liver whole cell lysates were evaluated for Egr-1 protein expression by Western blot analysis.
Positive_regulation (evaluated) of Gene_expression (expression) of Egr-1 in Liver
12) Confidence 0.50 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.46 Pain Relevance 0.20
Hemorrhagic shock results in a rapid and transient hepatic expression of Egr-1 mRNA in WT mice by 1 h, whereas protein and DNA binding activity was evident by 2.5 h.
Positive_regulation (results) of Gene_expression (expression) of Egr-1 associated with hemorrhagic shock
13) Confidence 0.50 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.43 Pain Relevance 0.24
Analyses of basal and brain stimulation-induced expression of other Egr family members suggest that the absence of deficits and the gain of function in certain tasks in Egr2-deficient mice is not due to compensatory expression of Egr1 or Egr3.


Positive_regulation (induced) of Gene_expression (expression) of Egr in brain
14) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.29 Pain Relevance 0
Our Western blot analyses also suggest that the normal performance of Egr2-deficient mice and the facilitation observed in certain tasks is not due to a compensatory overexpression, or a greater inducibility of the Egr family members known to be involved in learning and memory.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Egr
15) Confidence 0.50 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.76 Pain Relevance 0.04
In a similar vein, BDNF and zif268 mRNA expression were reported in the entorhinal and prefrontal cortices after object sampling, while in this experiment reactivation 9 days after training induced zif268 in entorhinal and somatosensory cortices and upon reactivation 21 days after training, BDNF and not zif268 was expressed in hippocampus and entorhinal and somatosensory cortices (Romero-Granados et al., 2010).
Positive_regulation (reactivation) of Neg (not) Gene_expression (expressed) of zif268 in vein associated with hippocampus
16) Confidence 0.49 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0 Pain Relevance 0.05
After the hindpaw injection of formalin in mice, we measured changes in expression of immediate early genes including c-fos, c-jun, jun B, nerve growth factor induced genes (NGFI-A and NGFI-B) and activity-related cytoskeletal protein (ARC) using real-time PCR.
Positive_regulation (changes) of Gene_expression (expression) of NGFI-A in nerve associated with nerve growth factor and aids-related complex
17) Confidence 0.49 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15389827 Disease Relevance 0.28 Pain Relevance 0.26
These findings illustrate that the impact of early life stress on gene expression changes is modulated by the genetic background and that the persistent changes in GR and egr-1 expression that arise early during postnatal developmental are reversible by chronic fluoxetine treatment during adolescence and adulthood.
Positive_regulation (arise) of Gene_expression (expression) of egr-1 associated with stress and fluoxetine
18) Confidence 0.48 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.79 Pain Relevance 0.20
Egr-1-overexpressing cells were analyzed for genes involved in invasion and metastasis.
Spec (analyzed) Positive_regulation (overexpressing) of Spec (analyzed) Gene_expression (overexpressing) of Egr-1-overexpressing associated with metastasis
19) Confidence 0.48 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.50 Pain Relevance 0.32
Cyclooxygenase (COX) inhibitors have antitumorigenic activity and increase the expression of the early growth response gene Egr-1, a tumor suppressor gene and transcription factor.
Positive_regulation (increase) of Gene_expression (expression) of Egr-1 associated with cancer
20) Confidence 0.48 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.41 Pain Relevance 0.17

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