INT5788

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 60
Total Number 71
Disease Relevance 40.67
Pain Relevance 9.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL2RA) plasma membrane (IL2RA)
Anatomy Link Frequency
T cells 16
IL2R 7
blood 5
regulatory T cells 4
effector T-cells 3
IL2RA (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 36 99.88 Very High Very High Very High
rheumatoid arthritis 425 99.80 Very High Very High Very High
Arthritis 696 99.76 Very High Very High Very High
Multiple sclerosis 13 99.40 Very High Very High Very High
Inflammation 411 99.00 Very High Very High Very High
cytokine 641 98.80 Very High Very High Very High
Osteoarthritis 45 97.68 Very High Very High Very High
tolerance 38 97.64 Very High Very High Very High
spinal inflammation 20 96.88 Very High Very High Very High
palliative 9 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 360 100.00 Very High Very High Very High
Diphtheria 68 100.00 Very High Very High Very High
Skin Cancer 38 99.84 Very High Very High Very High
Rheumatoid Arthritis 431 99.80 Very High Very High Very High
Juvenile Chronic Polyarthritis 466 99.76 Very High Very High Very High
Asthma 107 99.76 Very High Very High Very High
Hypersensitivity Pneumonitis 6 99.74 Very High Very High Very High
Cancer 1222 99.42 Very High Very High Very High
Disease 631 99.40 Very High Very High Very High
Demyelinating Disease 15 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sakaguchi et al. (1995) rekindled interest in the concept of T-cell-mediated suppression in the mid-1990s by showing that a minor population (~10%) of CD4+ T cells, which co-expresses the interleukin-2 receptor (IL-2R) ?
Gene_expression (expresses) of IL-2R in T-cell
1) Confidence 0.75 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0.96 Pain Relevance 0.08
Expression of IL-2Ralpha, IL-2Rbeta, and IL-2Rgamma in the pathological section was determined, respectively, by immunohistochemistry (IHC) and in situ hybridization (ISH).
Spec (determined) Gene_expression (Expression) of IL-2Ralpha
2) Confidence 0.75 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10778976 Disease Relevance 0.87 Pain Relevance 0.10
In the pathological sections, expression of IL-2Ralpha, IL-2Rbeta, and IL-2Rgamma was detected in 17 (18.1%), 83 (89.2%), and 83 (89.2%) cases, respectively, by IHC, and the message of IL-2Ralpha was identified in tumor cells by ISH in 30.1% (28 of 93) of the cases.
Gene_expression (expression) of IL-2Ralpha associated with cancer
3) Confidence 0.75 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10778976 Disease Relevance 0.92 Pain Relevance 0.06
Indeed, high- or intermediate affinity IL2R isoforms are expressed in at least 50% of CTCL and 25% to 50% of B-cell non-Hodgkin’s lymphomas when tissue is examined by flow cytometry, and thus make the IL2R an attractive target for therapy.16
Gene_expression (expressed) of IL2R in IL2R associated with lymphatic system cancer
4) Confidence 0.70 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.56 Pain Relevance 0.04
Indeed, high- or intermediate affinity IL2R isoforms are expressed in at least 50% of CTCL and 25% to 50% of B-cell non-Hodgkin’s lymphomas when tissue is examined by flow cytometry, and thus make the IL2R an attractive target for therapy.16
Gene_expression (make) of IL2R in IL2R associated with lymphatic system cancer
5) Confidence 0.70 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.65 Pain Relevance 0.03
Since the expression of IL2R has been largely thought to be important in T-cell targeting of denileukin diftitox, strategies to upregulate IL2R expression have been explored.
Gene_expression (expression) of IL2R in IL2R
6) Confidence 0.70 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.59 Pain Relevance 0
The generation of an anti-CD25 (anti-Tac) antibody has helped identify populations of cells where IL2R is expressed.15 In a normal subject, the IL2R is expressed mostly at a low level in less than 5% of normal circulating peripheral blood mononuclear cells (PBMC).
Gene_expression (expressed) of IL2R in blood
7) Confidence 0.70 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.58 Pain Relevance 0.05
Since the expression of IL2R has been largely thought to be important in T-cell targeting of denileukin diftitox, strategies to upregulate IL2R expression have been explored.
Gene_expression (expression) of IL2R in IL2R
8) Confidence 0.70 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.60 Pain Relevance 0
The numbers of CD4+CD25high Foxp3+ regulatory T cells in the synovial fluid of inflamed joints were comparable, but more CD4+CD25intermediate Foxp3+ regulatory T cells were present in persistent vs. extended oligoarticular JIA.
Gene_expression (regulatory T cells) of CD25 in regulatory T cells associated with arthritis
9) Confidence 0.65 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.05 Pain Relevance 0.31
METHODS: Chronic colitis was induced in SCID mice by injection of CD4(+)CD25(-) T cells.
Gene_expression (injection) of CD25 in T cells
10) Confidence 0.65 Published 2009 Journal Inflamm. Bowel Dis. Section Body Doc Link 19326358 Disease Relevance 0.10 Pain Relevance 0
The CD4/CD8 ratio is decreased, but the percentage of CD57+ cells is within the reference range.[7] Activation of T cells is increased in terms of human leukocyte antigen-DR expression; and occasionally, interleukin-2 receptor (CD25) is also expressed.
Gene_expression (expressed) of CD25 in leukocyte
11) Confidence 0.61 Published 2008 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2700454 Disease Relevance 1.40 Pain Relevance 0.07
These findings are similar to those in extrinsic allergic alveolitis except that CD25 expression is always within the reference range in patients with BOOP and levels of CD57+ cells are always increased in extrinsic allergic alveolitis.[7] Other features include central clusters of mononuclear inflammatory cells, possibly found in the intraluminal polyps; chronic inflammation in the walls of the surrounding alveoli with reactive type II cells; increased foamy macrophages in the alveoli; and preserved lung architecture.[5] Several causes of BOOP have been recorded but most cases are idiopathic.
Neg (except) Gene_expression (expression) of CD25 in macrophages associated with bronchiolitis obliterans organizing pneumonia, inflammation, polyps and hypersensitivity pneumonitis
12) Confidence 0.61 Published 2008 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2700454 Disease Relevance 1.47 Pain Relevance 0.09
The CD4/CD8 ratio is decreased, but the percentage of CD57+ cells is within the reference range.[7] Activation of T cells is increased in terms of human leukocyte antigen-DR expression; and occasionally, interleukin-2 receptor (CD25) is also expressed.
Gene_expression (expressed) of interleukin-2 receptor in leukocyte
13) Confidence 0.61 Published 2008 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2700454 Disease Relevance 1.41 Pain Relevance 0.07
Indeed, high- or intermediate affinity IL2R isoforms are expressed in at least 50% of CTCL and 25% to 50% of B-cell non-Hodgkin’s lymphomas when tissue is examined by flow cytometry, and thus make the IL2R an attractive target for therapy.16
Gene_expression (make) of IL2R in IL2R associated with lymphatic system cancer
14) Confidence 0.61 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.67 Pain Relevance 0.04
The IL2R-diphtheria toxin fusion protein: DAB486-IL2
Gene_expression (fusion protein) of IL2R-diphtheria in IL2R associated with diphtheria
15) Confidence 0.61 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.03 Pain Relevance 0.04
Modulation of the IL2R was seen with doses of bexarotene 150 mg daily and higher.
Gene_expression (Modulation) of IL2R in IL2R
16) Confidence 0.61 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.53 Pain Relevance 0
The generation of an anti-CD25 (anti-Tac) antibody has helped identify populations of cells where IL2R is expressed.15 In a normal subject, the IL2R is expressed mostly at a low level in less than 5% of normal circulating peripheral blood mononuclear cells (PBMC).
Gene_expression (expressed.15) of IL2R in blood
17) Confidence 0.61 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.52 Pain Relevance 0.05
CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells, produced in the thymus or periphery as a functionally mature T cell subpopulation, play pivotal roles in maintenance of self-tolerance and negative regulation of immune responses.
Gene_expression (produced) of CD25 in mature T cell associated with tolerance
18) Confidence 0.58 Published 2009 Journal Transpl. Immunol. Section Abstract Doc Link 19146957 Disease Relevance 0.24 Pain Relevance 0.35
The frequency of CD4(+)CD25(high) T cells and FOXP3 expression level did not correlate with age, duration, and total national institutes of health-chronic prostatitis symptom index score of CP/CPPS patients.
Gene_expression (expression) of CD25 in T cells
19) Confidence 0.58 Published 2010 Journal Urology Section Body Doc Link 19800664 Disease Relevance 0 Pain Relevance 0
This study was conducted to assess the prognostic value and source of sIL-2Ralpha in patients with ESCC.
Gene_expression (source) of IL-2Ralpha associated with skin cancer
20) Confidence 0.58 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10778976 Disease Relevance 0.69 Pain Relevance 0.08

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