INT5789

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 29
Disease Relevance 13.18
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PMEL) extracellular region (PMEL) Golgi apparatus (PMEL)
endoplasmic reticulum (PMEL) plasma membrane (PMEL)
Anatomy Link Frequency
melanocytes 5
A24 2
neural 2
neural crest 1
Cytotoxic T lymphocytes 1
PMEL (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 97.52 Very High Very High Very High
agonist 2 95.68 Very High Very High Very High
fortral 12 93.24 High High
melanocortin 1 receptor 9 92.32 High High
antagonist 8 91.04 High High
isoflurane 1 87.36 High High
Pain 29 86.28 High High
cva 26 84.00 Quite High
addiction 7 81.52 Quite High
Clonidine 2 76.92 Quite High
Disease Link Frequency Relevance Heat
Melanoma 198 100.00 Very High Very High Very High
Skin Cancer 174 99.80 Very High Very High Very High
Cancer 342 99.68 Very High Very High Very High
Necrosis 1 98.98 Very High Very High Very High
Influenza Virus Infection 6 98.12 Very High Very High Very High
Pancreatitis 12 97.96 Very High Very High Very High
Uremia 3 97.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 87 97.00 Very High Very High Very High
Hypopigmentation 102 96.36 Very High Very High Very High
Disease 94 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, serum levels of interleukin (IL)-4, IL-1beta, tumor necrosis factor (TNF)-alpha, adhesion molecules (sELAM, sICAM-1 and sVCAM), soluble receptors (sIL-2R, sCD30, sCD23) and IgE were assessed.
Gene_expression (levels) of sIL
1) Confidence 0.75 Published 2002 Journal Int. J. Dermatol. Section Body Doc Link 12121561 Disease Relevance 0.19 Pain Relevance 0
We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, INF-alpha, tumor necrosis factor (TNF)-alpha and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.
Gene_expression (synthesis) of sIL
2) Confidence 0.75 Published 1998 Journal Anaesthesist Section Body Doc Link 9645277 Disease Relevance 0.07 Pain Relevance 0
We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.
Gene_expression (synthesis) of sIL associated with necrosis, anesthesia and cancer
3) Confidence 0.75 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.36 Pain Relevance 0.52
Thus, gp100 is expressed in most malignant melanomas.
Gene_expression (expressed) of gp100 associated with melanoma
4) Confidence 0.68 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.81 Pain Relevance 0
These adverse events might be associated with the vaccination, since gp100 is also expressed by the non-cancerous melanocytes.
Gene_expression (expressed) of gp100 in melanocytes
5) Confidence 0.68 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 1.24 Pain Relevance 0.09
Although there was no significant difference in sIL-2Ralpha levels between the control group and the patient groups, we found a slight correlation between sIL-2Ralpha and CA 19-9 levels in the pancreatic cancer group (p = 0.003, r = 0.623) and a more marked correlation in the chronic pancreatitis group (p < 0.01, r = 0.751).
Gene_expression (levels) of sIL
6) Confidence 0.65 Published 2004 Journal Int. J. Biol. Markers Section Body Doc Link 15503821 Disease Relevance 0.13 Pain Relevance 0
The laboratory data includes: IgG 1270 mg/dl, IgA 369mg/dl, IgM 326mg/dl, C'3 65.2 mg/dl, C'4 16.3 mg/dl, and serum soluble interleukin-2 receptor level (sIL-2R) greater than 6000U/ml.
Gene_expression (326mg/dl) of sIL
7) Confidence 0.65 Published 1992 Journal Zhonghua Yi Xue Za Zhi (Taipei) Section Abstract Doc Link 1316215 Disease Relevance 1.12 Pain Relevance 0.34
Serum sIL-2R concentrations were significantly higher in patients with severe pancreatitis than in those with the mild form of the disease, whereas no differences in serum concentrations of sCD8 and sCD4 were found between patients with mild pancreatitis and those with severe disease.
Gene_expression (concentrations) of sIL associated with pancreatitis and disease
8) Confidence 0.65 Published 1994 Journal Digestion Section Abstract Doc Link 8063032 Disease Relevance 1.33 Pain Relevance 0.10
The laboratory data includes: IgG 1270 mg/dl, IgA 369mg/dl, IgM 326mg/dl, C'3 65.2 mg/dl, C'4 16.3 mg/dl, and serum soluble interleukin-2 receptor level (sIL-2R) greater than 6000U/ml.
Gene_expression (level) of sIL
9) Confidence 0.65 Published 1992 Journal Zhonghua Yi Xue Za Zhi (Taipei) Section Abstract Doc Link 1316215 Disease Relevance 1.09 Pain Relevance 0.33
The laboratory data includes: IgG 1270 mg/dl, IgA 369mg/dl, IgM 326mg/dl, C'3 65.2 mg/dl, C'4 16.3 mg/dl, and serum soluble interleukin-2 receptor level (sIL-2R) greater than 6000U/ml.
Gene_expression (369mg/dl) of sIL
10) Confidence 0.65 Published 1992 Journal Zhonghua Yi Xue Za Zhi (Taipei) Section Abstract Doc Link 1316215 Disease Relevance 1.12 Pain Relevance 0.34
Patients' PBMCs were stimulated in culture with the gp100-in4 peptide, and the cells capable of producing IFN-?
Gene_expression (peptide) of gp100-in4
11) Confidence 0.59 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.16 Pain Relevance 0
The peptide, termed gp100-in4 (VYFFLPDHL), was observed to be expressed only at low levels, but the CTLs can recognize very small amounts of the cell surface HLA/peptide complex.
Gene_expression (expressed) of gp100-in4
12) Confidence 0.59 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.61 Pain Relevance 0
In contrast, MART-1, S100-specific protein, and gp-100 were only expressed by 66%, 33%, and 67% of the analyzed samples, respectively.
Gene_expression (expressed) of gp-100
13) Confidence 0.58 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17325166 Disease Relevance 0.07 Pain Relevance 0
The tumor cells strongly expressed S100 protein, gp100 (HMB-45), melan A, and tyrosine antibodies (Fig. 2C,D).
Gene_expression (expressed) of gp100 associated with cancer
14) Confidence 0.55 Published 2004 Journal Int. J. Dermatol. Section Abstract Doc Link 15485534 Disease Relevance 0.59 Pain Relevance 0.06
Human melanoma-specific HLA-A2 restricted CTLs have recently been shown to recognize antigens expressed by melanoma lines and normal melanocytes, including Melan-A/Mart-1, gp100, gp75, and tyrosinase.
Gene_expression (expressed) of gp100 in melanocytes associated with melanoma
15) Confidence 0.53 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9331097 Disease Relevance 0.36 Pain Relevance 0.26
Cytotoxic T lymphocytes (CTLs) clones specific to gp100-in4 were successfully established from the PBMC of some patients and these CTL clones were capable of lysing the melanoma cell line, 888 mel, which endogenously expresses HLA-restricted gp100-in4.


Gene_expression (expresses) of gp100-in4 in Cytotoxic T lymphocytes associated with melanoma
16) Confidence 0.53 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2949666 Disease Relevance 0.31 Pain Relevance 0
Partly this was because in seven studies [1,3,4,13,15-17] subjects had been, or appeared to have been, selected on the basis of SIL being present, but this was not always the case [2,5,18,19].
Gene_expression (present) of SIL
17) Confidence 0.52 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2390522 Disease Relevance 0.31 Pain Relevance 0.09
These CTL clones also were able to lyse 888 mel, which naturally express gp100 [gp100 (+), HLA-A24 (+)], but were unable to lyse 397 mel [gp100 (+), HLA-A24 (-)] or HT29 [gp100 (-), HLA-A24 (+)].
Gene_expression (express) of gp100 in A24
18) Confidence 0.46 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.10 Pain Relevance 0
These CTL clones also were able to lyse 888 mel, which naturally express gp100 [gp100 (+), HLA-A24 (+)], but were unable to lyse 397 mel [gp100 (+), HLA-A24 (-)] or HT29 [gp100 (-), HLA-A24 (+)].
Gene_expression (express) of gp100 in A24
19) Confidence 0.46 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.10 Pain Relevance 0
No change was observed in expression of gp75, neural specific octamer binding proteins, or in mRNA levels of tyrosinase, Pmel-17 and gp75 (TRP-1).
Gene_expression (levels) of Pmel-17 in neural
20) Confidence 0.40 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.41 Pain Relevance 0.28

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