INT57920

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Context Info
Confidence 0.64
First Reported 1993
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.70
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
PRP 2
corpus striatum 1
platelets 1
PRN 1
Prnp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 18 99.38 Very High Very High Very High
sSRI 22 99.32 Very High Very High Very High
Dopamine 12 98.96 Very High Very High Very High
tolerance 10 92.64 High High
Eae 8 87.84 High High
antidepressant 4 78.92 Quite High
medulla 4 75.00 Quite High
excitatory amino acid 2 73.24 Quite High
Angina 2 72.88 Quite High
Serotonin 4 56.64 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 4 97.04 Very High Very High Very High
Myocardial Infarction 2 73.92 Quite High
Cv General 3 Under Development 2 72.88 Quite High
Depression 4 52.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, subchronic treatment with fluoxetine was followed by a significant increase in 5-HT levels in PRP, while the same SSRI treatment performed within the FST resulted in a decrease in the 5-HT levels in PRP.
Positive_regulation (increase) of PRP associated with ssri and fluoxetine
1) Confidence 0.64 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11880895 Disease Relevance 0.05 Pain Relevance 0.72
Accordingly, the present data show that the initial block of 5-HT reuptake is revealed by the selective increase in 5-HT levels (extracellular content) measured in PRP (not in insulated platelets, IPs) the 1st day of fluoxetine treatment.
Positive_regulation (increase) of PRP in platelets associated with fluoxetine
2) Confidence 0.56 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11880895 Disease Relevance 0 Pain Relevance 0.71
During NTG infusion, platelet-rich plasma (PRP) cyclic GMP was increased by 41.4 +/- 13.6% as compared with control and remained increased throughout the infusion (p < 0.05).
Positive_regulation (increased) of PRP in PRP
3) Confidence 0.51 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877591 Disease Relevance 0.32 Pain Relevance 0.24
Furthermore, the enhanced release of dopamine-like material induced by amphetamine was attenuated by simultaneous stimulation of the PRN.
Positive_regulation (stimulation) of PRN in PRN associated with dopamine
4) Confidence 0.41 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8232603 Disease Relevance 0 Pain Relevance 0.46
In vivo voltammetric data revealed that electrical stimulation of the PRN decreased the release of dopamine-like material in the corpus striatum.
Positive_regulation (stimulation) of PRN in corpus striatum associated with dopamine
5) Confidence 0.41 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8232603 Disease Relevance 0 Pain Relevance 0.48
During NTG infusion, platelet-rich plasma (PRP) cyclic GMP was increased by 41.4 +/- 13.6% as compared with control and remained increased throughout the infusion (p < 0.05).
Positive_regulation (increased) of PRP in PRP
6) Confidence 0.37 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877591 Disease Relevance 0.33 Pain Relevance 0.26

General Comments

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