INT57922

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 65
Total Number 69
Disease Relevance 22.24
Pain Relevance 7.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9)
Anatomy Link Frequency
liver 11
endothelial cells 3
1A2 2
hearts 2
hepatocytes 1
CYP2C9 (Homo sapiens)
CYP2C9 - R144C (1)
Pain Link Frequency Relevance Heat
depression 47 100.00 Very High Very High Very High
halothane 3 98.88 Very High Very High Very High
cINOD 39 98.72 Very High Very High Very High
ketamine 13 98.72 Very High Very High Very High
antidepressant 44 98.14 Very High Very High Very High
rapifen 7 97.82 Very High Very High Very High
diclofenac 4 97.74 Very High Very High Very High
Morphine 22 97.68 Very High Very High Very High
fluoxetine 36 96.80 Very High Very High Very High
antagonist 90 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 53 100.00 Very High Very High Very High
Nicotine Addiction 212 99.96 Very High Very High Very High
Renal Cancer 6 99.96 Very High Very High Very High
Toxicity 55 99.92 Very High Very High Very High
Hypoxia 32 99.70 Very High Very High Very High
Malignant Neoplastic Disease 21 99.68 Very High Very High Very High
Hepatocellular Cancer 38 99.60 Very High Very High Very High
Prostate Cancer 35 99.60 Very High Very High Very High
Hepatitis 12 99.24 Very High Very High Very High
Adverse Drug Reaction 25 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the role of cytochrome P4502C10 in the metabolism of the non-steroidal antiinflammatory drugs (NSAIDs) diclofenac, phenylbutazone, fenoprofen, ibuprofen, flurbiprofen, ketoprofen and naproxen, a cell line was developed stably expressing CYP2C10 cDNA.
Gene_expression (expressing) of CYP2C10 associated with inflammation, cinod and diclofenac
1) Confidence 0.78 Published 1996 Journal Xenobiotica Section Abstract Doc Link 9004453 Disease Relevance 0.17 Pain Relevance 0.31
Cytochrome P450 (CYP) superfamily members CYP2C8 and CYP2C9 are polymorphically expressed enzymes that are involved in the metabolic inactivation of several drugs, including, among others, antiepileptics, NSAIDs, oral hypoglycemics, and anticoagulants.
Gene_expression (expressed) of CYP2C9 associated with cinod
2) Confidence 0.77 Published 2006 Journal Molecular diagnosis & therapy Section Abstract Doc Link 16646575 Disease Relevance 0 Pain Relevance 0.10
OBJECTIVE: To analyse the influence of age and cytochrome P450 (CYP) 2C9 genotype on the steady-state disposition of the standard NSAID diclofenac and the new COX-2 selective inhibitor celecoxib, both of which are metabolised by the polymorphically expressed CYP2C9.
Gene_expression (expressed) of CYP2C9 associated with cinod and diclofenac
3) Confidence 0.77 Published 2003 Journal Clin Pharmacokinet Section Abstract Doc Link 12603175 Disease Relevance 0 Pain Relevance 0.18
Expressed CYP2C9, CYP2C19, and CYP2D6 formed R-norfluoxetine following incubation with 1 microM R-fluoxetine and exhibited apparent K(m) values of 9.7, 8.5, and 1.8 microM, respectively.
Gene_expression (Expressed) of CYP2C9 associated with fluoxetine
4) Confidence 0.76 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11356927 Disease Relevance 0 Pain Relevance 0.16
While recombinant CYP2C19 and CYP2C9 proteins expressed in yeast or Escherichia coli have been shown to oxidize these agents, the capacity of the corresponding native P450s isolated from human liver to do so is ill defined.
Gene_expression (expressed) of CYP2C9 in liver
5) Confidence 0.76 Published 1998 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 9578596 Disease Relevance 0.10 Pain Relevance 0.10
Finally, immunoquantitation revealed that in these human liver samples, expression of CYP2C9 (88. 5 +/- 36 nmol/mg) was 5-fold higher than that of CYP2C19 (17.8 +/- 14 nmol/mg) and nearly 8-fold higher than that of CYP2C8 (11.5 +/- 12 nmol/mg).
Gene_expression (expression) of CYP2C9 in liver
6) Confidence 0.76 Published 1998 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 9578596 Disease Relevance 0 Pain Relevance 0
The KM values were 9.9 +/- 1.2 and 117.1 +/- 13.8 microM and the Vmax values were 0.33 +/- 0.05 and 0.24 +/- 0.04 pmol/min/pmol CYP in microsomes with cDNA-expressed CYP2C9 and CYP2C19, respectively (N = 4).
Gene_expression (expressed) of CYP2C9
7) Confidence 0.75 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9492390 Disease Relevance 0 Pain Relevance 0
These transformants are designated Hepc/1A1.4, Hepc/1A2.9, Hepc/2A6L.14, Hepc/2B6.68, Hepc/2C8.46, Hepc/2C9.1, Hepc/2C19.12, Hepc/2D6.39, Hepc/2E1.3-8 and Hepc/3A4.2-30, which stably expressed human CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4, respectively.
Gene_expression (expressed) of CYP2C9 in 1A2
8) Confidence 0.70 Published 2001 Journal Toxicol In Vitro Section Abstract Doc Link 11377097 Disease Relevance 0 Pain Relevance 0.05
This result supports data obtained in rats indicating that chronic hypoxia led to an increase in rat CYP2C9 expression in mesenteric arteries.[27] It has also been reported that hypoxia increases the expression of CYP2C mRNAs and proteins and enhanced 11,12-EET production in human endothelial cells.[28] The fact that CYP2C9 mRNA was detected in only 10% of our samples and increased in ischemic hearts may suggest that a certain amount of this mRNA originates from endothelial cells in some but not in other ventricular samples.
Gene_expression (detected) of CYP2C9 mRNA in hearts associated with hypoxia
9) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.26 Pain Relevance 0
This result supports data obtained in rats indicating that chronic hypoxia led to an increase in rat CYP2C9 expression in mesenteric arteries.[27] It has also been reported that hypoxia increases the expression of CYP2C mRNAs and proteins and enhanced 11,12-EET production in human endothelial cells.[28] The fact that CYP2C9 mRNA was detected in only 10% of our samples and increased in ischemic hearts may suggest that a certain amount of this mRNA originates from endothelial cells in some but not in other ventricular samples.
Gene_expression (expression) of CYP2C9 in endothelial cells associated with hypoxia
10) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.20 Pain Relevance 0
This result supports data obtained in rats indicating that chronic hypoxia led to an increase in rat CYP2C9 expression in mesenteric arteries.[27] It has also been reported that hypoxia increases the expression of CYP2C mRNAs and proteins and enhanced 11,12-EET production in human endothelial cells.[28] The fact that CYP2C9 mRNA was detected in only 10% of our samples and increased in ischemic hearts may suggest that a certain amount of this mRNA originates from endothelial cells in some but not in other ventricular samples.
Gene_expression (expression) of CYP2C in endothelial cells associated with hypoxia
11) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.25 Pain Relevance 0
The CYP2C10 gene could not be found in any of the samples studied.
Neg (not) Gene_expression (found) of CYP2C10 gene
12) Confidence 0.68 Published 1996 Journal Pharmacogenetics Section Abstract Doc Link 8946475 Disease Relevance 0.06 Pain Relevance 0.06
We measured single-dose kinetics of celecoxib and its main metabolites hydroxy- and carboxy-celecoxib in 21 healthy volunteers who were selected as hetero- (n = 4) and homozygous (n = 3) carriers of CYP2C9 variants Arg144Cys (*2) and Ile359Leu (*3).
Gene_expression (carriers) of CYP2C9 (R144C)
13) Confidence 0.68 Published 2003 Journal Pharmacogenetics Section Abstract Doc Link 12893985 Disease Relevance 0.08 Pain Relevance 0.08
CYP2C9*3 were detected in all the three races with the Indians having the highest frequency of CYP2C9*3 (9.7%).
Gene_expression (detected) of CYP2C9
14) Confidence 0.67 Published 2006 Journal J Clin Pharm Ther Section Body Doc Link 16635054 Disease Relevance 0 Pain Relevance 0
Here we present frequencies of the most common CYP2C9 coding variants CYP2C9*2 (C430T) and CYP2C9*3 (A1075C) in representative samples of four regions from Spain (Basque Country, n=358; Catalonia, n=240; Central Spain, n=190 and Galicia, n=288) and one northern Italian region, (Verona, n=164), which range between 0.125 and 0.165 in the case of CYP2C9*2 and between 0.071 and 0.085 for CYP2C9*3.
Gene_expression (present) of CYP2C9
15) Confidence 0.67 Published 2009 Journal Pharmacogenomics J. Section Abstract Doc Link 19381164 Disease Relevance 0.10 Pain Relevance 0
Here we present frequencies of the most common CYP2C9 coding variants CYP2C9*2 (C430T) and CYP2C9*3 (A1075C) in representative samples of four regions from Spain (Basque Country, n=358; Catalonia, n=240; Central Spain, n=190 and Galicia, n=288) and one northern Italian region, (Verona, n=164), which range between 0.125 and 0.165 in the case of CYP2C9*2 and between 0.071 and 0.085 for CYP2C9*3.
Gene_expression (range) of CYP2C9
16) Confidence 0.67 Published 2009 Journal Pharmacogenomics J. Section Abstract Doc Link 19381164 Disease Relevance 0.09 Pain Relevance 0
Rapid detection of CYP2C9*3 alleles by real-time fluorescence PCR based on SYBR Green.
Gene_expression (detection) of CYP2C9
17) Confidence 0.66 Published 1999 Journal Mol. Genet. Metab. Section Title Doc Link 10562462 Disease Relevance 0.09 Pain Relevance 0.09
We developed a rapid mutation analysis method for detecting the CYP2C9*1 genotype.
Gene_expression (detecting) of CYP2C9
18) Confidence 0.66 Published 1999 Journal Mol. Genet. Metab. Section Abstract Doc Link 10562462 Disease Relevance 0.09 Pain Relevance 0.09
Sequence analysis of the different PCR products revealed that other genes in the CYP2C locus were co-amplified in one of the methods applied, whereas the other two methods were specific for CYP2C9.
Gene_expression (specific) of CYP2C9
19) Confidence 0.66 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9920790 Disease Relevance 0.08 Pain Relevance 0.08
Despite its tolbutamide hydroxylase activity, the low levels of hepatic CYP2C19 expression (relative to CYP2C9) may preclude an important role for this enzyme in hepatic tolbutamide metabolism and any polymorphisms thereof.
Gene_expression (expression) of CYP2C9
20) Confidence 0.66 Published 1998 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 9578596 Disease Relevance 0 Pain Relevance 0

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