INT57939

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.15
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
striatum 4
plasma 2
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 16 100.00 Very High Very High Very High
Locus ceruleus 3 99.70 Very High Very High Very High
Dopamine 11 99.52 Very High Very High Very High
Enkephalin 7 98.72 Very High Very High Very High
Substantia nigra 2 89.60 High High
depression 2 82.64 Quite High
Eae 2 81.52 Quite High
Clonidine 1 75.04 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 2 97.12 Very High Very High Very High
Disease 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Basal Ganglia Disease 2 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of a change in A2A receptor gene expression after 6-OH-dopamine treatment speaks against a dependency on dopaminergic innervation.
Negative_regulation (absence) of Gene_expression (expression) of A2A receptor gene associated with dopamine
1) Confidence 0.36 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11041267 Disease Relevance 0 Pain Relevance 0.67
In the rat striatum, expression of A2A receptors was not significantly altered after lesion of the dopaminergic pathways with 6-OH-dopamine even though enkephalin gene expression was up-regulated.
Neg (not) Negative_regulation (altered) of Gene_expression (expression) of A2A in striatum associated with dopamine and enkephalin
2) Confidence 0.36 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11041267 Disease Relevance 0 Pain Relevance 0.66
In the old striatum, the levels of adenosine A2 receptor mRNA and adenosine A2 binding sites were reduced by 32% and 20%, respectively.
Negative_regulation (reduced) of Gene_expression (levels) of adenosine A2 receptor mRNA in striatum associated with adenocard
3) Confidence 0.35 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8233082 Disease Relevance 0 Pain Relevance 0.50
Taken together, the data indicate that administration of AS-ODN against alpha2A-ARs in the LC significantly reduced expression of alpha2A-AR mRNA in brain stem, moderately increased plasma corticosterone and had anxiolytic-like effect in the elevated plus-maze.
Negative_regulation (reduced) of Gene_expression (expression) of alpha2A-AR in plasma associated with locus ceruleus and anxiety disorder
4) Confidence 0.09 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965357 Disease Relevance 0.15 Pain Relevance 0.19

General Comments

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