INT57957

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Context Info
Confidence 0.64
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.01
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TXNRD1) small molecule metabolic process (TXNRD1) cytoplasm (TXNRD1)
cytosol (TXNRD1) signal transduction (TXNRD1) oxidoreductase activity (TXNRD1)
Anatomy Link Frequency
trigeminal nerve 2
monocytes 1
leukocytes 1
posterior 1
trapezius 1
TXNRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Myofascial pain syndrome 15 100.00 Very High Very High Very High
Pain 3 99.60 Very High Very High Very High
cytokine 19 98.80 Very High Very High Very High
neuralgia 3 97.04 Very High Very High Very High
Face pain 2 96.56 Very High Very High Very High
Cancer pain 1 95.16 Very High Very High Very High
fluoxetine 7 94.10 High High
medulla 2 94.04 High High
tolerance 3 91.20 High High
Fibrositis 2 91.16 High High
Disease Link Frequency Relevance Heat
Myofascial Pain Syndromes 15 100.00 Very High Very High Very High
Pain 2 99.60 Very High Very High Very High
Stress 24 99.44 Very High Very High Very High
Syndrome 2 99.40 Very High Very High Very High
Herpes Zoster Oticus 1 97.48 Very High Very High Very High
Epstein-barr Virus 142 97.00 Very High Very High Very High
Headache 6 96.56 Very High Very High Very High
Cancer Pain 1 95.16 Very High Very High Very High
Neuralgia 2 94.12 High High
Bacterial Infection 1 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When osmotic pressure of release media increased, the significant change of the equilibrium solubility of TR was not found, but the release rates of TR MPOP decreased significantly.
Localization (release) of TR
1) Confidence 0.64 Published 2007 Journal Yao Xue Xue Bao Section Abstract Doc Link 17518057 Disease Relevance 0 Pain Relevance 0.11
The authors hypothesize that TrPs are caused by sympathetically activated intrafusal contractions.
Localization (caused) of TrPs associated with myofascial pain syndrome
2) Confidence 0.45 Published 1993 Journal Spine Section Abstract Doc Link 8235865 Disease Relevance 0.80 Pain Relevance 0.76
Considering rotation of the mandible around the PtmS, MR releases the restrictive element of the PtmS, while TR releases tension posterior to the PtmS allowing forward rotation of the mandible.
Localization (releases) of TR in posterior
3) Confidence 0.28 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2703201 Disease Relevance 0.07 Pain Relevance 0
Unfortunately, the complete genomic sequence of the goldfish TR?
Localization (sequence) of TR
4) Confidence 0.23 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
(translation: TR)
Localization (translation) of TR
5) Confidence 0.19 Published 2008 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736519 Disease Relevance 0 Pain Relevance 0
Detection of BZLF1 protein by Western blot, TR sequences by Southern blot, and interphase FISH can be applied to recognize cell lines producing active EBV particles and to assign a cell culture to a legal risk group.
Localization (Detection) of TR associated with epstein-barr virus
6) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2861168 Disease Relevance 0.87 Pain Relevance 0
Trigeminal TR and/or NC procedures can be used in a large group of pain syndromes, such as glossopharyngeal, vagal, and geniculate neuralgias, atypical facial pain, craniofacial cancer pain, postherpetic neuralgias, and atypical forms of trigeminal neuralgia.
Localization (used) of TR associated with herpes zoster oticus, pain, neuralgia, cancer pain, syndrome and face pain
7) Confidence 0.10 Published 2008 Journal Neurosurgery Section Abstract Doc Link 18728592 Disease Relevance 0.68 Pain Relevance 0.62
DC10, defined as monocyte-derived DCs generated in the presence of IL-10, promote IL-10-secreting anergic CD4+ T cells with suppressive functions (T regulatory type 1, Tr1 or IL-10-Treg).
Localization (secreting) of Tr1 in T cells
8) Confidence 0.10 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.13 Pain Relevance 0.05
In addition, TrxR was found to be secreted by activated monocytes and might be part of an extracellular Trx1 reducing system (Soderberg et al, 2000).
Localization (secreted) of TrxR in monocytes
9) Confidence 0.09 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1

The thiol-disulfide oxidoreductase thioredoxin-1 (Trx1) is known to be secreted by leukocytes and to exhibit cytokine-like properties.

Localization (secreted) of oxidoreductase in leukocytes associated with cytokine
10) Confidence 0.08 Published 2007 Journal EMBO J Section Title Doc Link PMC1914094 Disease Relevance 0.15 Pain Relevance 0.17
METHODS: Of 1000 patients who underwent RF-TR, 100 were retrospective and randomly selected and divided into study groups according to postoperative hypoesthesia in the trigeminal nerve divisions.
Localization (retrospective) of RF-TR in trigeminal nerve
11) Confidence 0.07 Published 2008 Journal Neurosurgery Section Body Doc Link 18728590 Disease Relevance 0 Pain Relevance 0
METHODS: Of 1000 patients who underwent RF-TR, 100 were retrospective and randomly selected and divided into study groups according to postoperative hypoesthesia in the trigeminal nerve divisions.
Localization (selected) of RF-TR in trigeminal nerve
12) Confidence 0.07 Published 2008 Journal Neurosurgery Section Body Doc Link 18728590 Disease Relevance 0 Pain Relevance 0
To summarize, for the trapezius muscle, this study demonstrates that two trained examiners can reliably localize latent TrPs with a precision that essentially approaches the physical dimensions of the clinician's own fingertips.
Localization (localize) of TrPs in trapezius associated with myofascial pain syndrome
13) Confidence 0.01 Published 2001 Journal Pain Section Abstract Doc Link 11514085 Disease Relevance 0.23 Pain Relevance 0.23
Chronic fluoxetine administration to stressed animals for 21 days prevented restraint stress-induced oxidative damage with an efficacy similar to that of turmeric, as evidenced by significant enhancement of key endogenous antioxidant defense components, comprising the free-radical scavenging enzymes, superoxide:superoxide oxidoreductase (EC 1.15.1.1), hydrogen-peroxide:hydrogen-peroxide oxidoreductase (EC 1.11.1.6), glutathione S-transferase (EC 2.5.1.18) and glutathione:NADP(+)oxidoreductase (EC 1.8.1.7), as well as non-enzymatic antioxidants, GSH, glucose and uric acid, which were severely depleted by restraint stress in animals receiving no treatment.
Localization (depleted) of superoxide oxidoreductase associated with stress and fluoxetine
14) Confidence 0.00 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17610875 Disease Relevance 0.99 Pain Relevance 0.72

General Comments

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