INT57958

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Context Info
Confidence 0.41
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.52
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Myo5a) Golgi apparatus (Myo5a) cytoplasm (Myo5a)
Anatomy Link Frequency
vasculature 1
EDL 1
T cells 1
Myo5a (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 74 95.60 Very High Very High Very High
Paracetamol 5 93.36 High High
induced neuropathy 1 86.24 High High
anakinra 4 74.16 Quite High
Inflammation 6 54.16 Quite High
rheumatoid arthritis 2 47.24 Quite Low
cytokine 4 44.48 Quite Low
cINOD 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 76 100.00 Very High Very High Very High
Syndrome 70 99.92 Very High Very High Very High
Cancer 121 99.68 Very High Very High Very High
Disease 21 98.08 Very High Very High Very High
Sprains And Strains 73 96.76 Very High Very High Very High
Infection 114 95.40 Very High Very High Very High
Immunization 53 92.80 High High
Influenza Virus Infection 163 91.16 High High
Microcephaly 2 85.04 High High
Fever 42 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These titers were significantly higher than that of mice that were vaccinated with MVA-HA-VN/04 at a dose of 104, 105, 106 or 108 pfu (p<0.05).
Positive_regulation (vaccinated) of MVA-HA-VN/04
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 1.20 Pain Relevance 0
Of course the minimal requirements for the induction of protective immunity by MVA-HA-VN/04 vaccination need to be confirmed in humans.
Positive_regulation (vaccination) of MVA-HA-VN/04
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.57 Pain Relevance 0
MVA constructs induced slightly higher levels of CD8 T cells than the Lister constructs.
Positive_regulation (induced) of MVA in T cells
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.08 Pain Relevance 0
However, depolarization increased the percentage of bimodal MEPP amplitude in STZ-D compared to control (p<0.01) mice in EDL but not soleus.
Positive_regulation (increased) of STZ-D in EDL
4) Confidence 0.22 Published 1999 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 10230736 Disease Relevance 0.13 Pain Relevance 0.09
We speculate that the delivery of d-luciferin to the tumor was slow early after cell inoculation due to insufficient vascularization, which made the elevation of intratumoral d-luciferin concentration timeconsuming.
Positive_regulation (elevation) of d-luciferin associated with cancer
5) Confidence 0.16 Published 2010 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2910476 Disease Relevance 0.72 Pain Relevance 0.11
Later, the establishment of the tumor vasculature likely enhanced the delivery of d-luciferin to the tumor, which shortened the peak time.
Positive_regulation (enhanced) of d-luciferin in vasculature associated with cancer
6) Confidence 0.12 Published 2010 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2910476 Disease Relevance 0.71 Pain Relevance 0.11
In contrast, no residual activity is present in MVA patients [4].


Positive_regulation (present) of MVA associated with mevalonate kinase deficiency
7) Confidence 0.03 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1475558 Disease Relevance 1.94 Pain Relevance 0.03
MVA is caused by homozygosity or compound heterozygosity for disease-causing mutations in the MVK gene, which has been localized to chromosome 12q24 [2].
Positive_regulation (caused) of MVA associated with mevalonate kinase deficiency and disease
8) Confidence 0.03 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1475558 Disease Relevance 2.11 Pain Relevance 0.04
The immunodetectable protein level of cytochrome P2B1 in non-acetone treated mouse was increased 18 h after D-limonene, with no differences in P2E1 or P1A1. 4.
Neg (no) Positive_regulation (increased) of D-limonene
9) Confidence 0.01 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8237062 Disease Relevance 0.06 Pain Relevance 0.41

General Comments

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