INT57959

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1993
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.29
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1)
plasma membrane (Prf1) transmembrane transport (Prf1)
Anatomy Link Frequency
blood 1
lymphocytes 1
lung 1
PSP 1
Prf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 55 99.80 Very High Very High Very High
tetrodotoxin 2 97.16 Very High Very High Very High
Paracetamol 5 96.32 Very High Very High Very High
imagery 12 93.64 High High
Inflammation 64 86.88 High High
anesthesia 13 75.00 Quite High
cytokine 18 73.04 Quite High
analgesia 2 70.72 Quite High
metalloproteinase 40 69.84 Quite High
ketamine 5 68.16 Quite High
Disease Link Frequency Relevance Heat
Poisoning 86 100.00 Very High Very High Very High
Pulmonary Disease 88 99.70 Very High Very High Very High
Nicotine Addiction 4 98.44 Very High Very High Very High
Syndrome 13 97.86 Very High Very High Very High
Shellfish Poisoning 34 97.72 Very High Very High Very High
Apoptosis 72 97.20 Very High Very High Very High
Influenza Virus Infection 82 92.80 High High
Toxicity 24 90.16 High High
INFLAMMATION 57 86.88 High High
Cancer 197 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes important for sequential activation of caspases cascade Casp12, Casp7, Prf1, Gzmb were also down-regulated in mice fed with HF diet, however the apoptosis inhibitor proteins Birc2, Birc5 were suppressed.
Positive_regulation (activation) of Prf1 associated with apoptosis
1) Confidence 0.41 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.50 Pain Relevance 0
Using these established techniques to analyze BBB disruption, we have determined that perforin is necessary for CNS vascular permeability in this model and that autofluorescence is not an appropriate method of analysis.
Positive_regulation (necessary) of perforin associated with central nervous system
2) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.19 Pain Relevance 0.17
CHL in P1, but significantly increased in P2 (P1: 1.5+/-0.2%, 1.1+/-0.2%, 31+/-3%; percent change in P2: 122+/-23, 128+/-21 and 29+/-6 respectively; each p<0.05 vs.
Positive_regulation (increased) of P1
3) Confidence 0.33 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15549274 Disease Relevance 0.20 Pain Relevance 0.31
CHL in P1, but significantly increased in P2 (P1: 1.5+/-0.2%, 1.1+/-0.2%, 31+/-3%; percent change in P2: 122+/-23, 128+/-21 and 29+/-6 respectively; each p<0.05 vs.
Positive_regulation (increased) of P1
4) Confidence 0.33 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15549274 Disease Relevance 0.20 Pain Relevance 0.36
To test this hypothesis, we compared two cell lines derived from second generation lung colonies (P2) in which P2M3C was derived from pooled P1 STAT1H cell lines (P2H) and P2M6B was derived from pooled P1 STAT1L cell lines (P2L) (Figure 3 and Figure S2).
Positive_regulation (pooled) of P1 in lung
5) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.47 Pain Relevance 0
The mean STAT1 expression score shows a progressive increase from the P1 to the P3 passage with a significant difference between the P1 and P3 panels of cell lines (Student's two-tailed t-test; p?
Positive_regulation (increase) of P1
6) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.06 Pain Relevance 0
We propose that the food-poisoning syndrome caused by intoxication from STX exposure from fish should be characterized as SPFP to distinguish it from PFP, which is caused by—but not always verified to be from—TTX, and to distinguish SPFP from PSP associated with STXs in shellfish.
Neg (not) Positive_regulation (caused) of PFP in PSP associated with syndrome, shellfish poisoning and poisoning
7) Confidence 0.11 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1626430 Disease Relevance 1.01 Pain Relevance 0
Puffer fish poisoning (PFP) is usually caused by ingestion of tetrodotoxins (TTXs) found naturally in certain species of puffer fish (Halstead 1967; Mosher and Fuhrmann 1984).
Positive_regulation (caused) of PFP associated with poisoning
8) Confidence 0.09 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1626430 Disease Relevance 0.87 Pain Relevance 0.10
Importantly, splenectomy abrogates perforin stimulation in CD8 lymphocytes from BLV-infected splenectomized sheep (Figure 4A, right panels).
Positive_regulation (stimulation) of perforin in lymphocytes
9) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736388 Disease Relevance 0 Pain Relevance 0
These results are indicative of a contact-dependent mechanism requiring perforin and/or Fas.
Positive_regulation (requiring) of perforin
10) Confidence 0.06 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 0.49 Pain Relevance 0.03
The immunodetectable protein level of cytochrome P2B1 in non-acetone treated mouse was increased 18 h after D-limonene, with no differences in P2E1 or P1A1. 4.
Neg (no) Positive_regulation (increased) of P1A1
11) Confidence 0.03 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8237062 Disease Relevance 0.06 Pain Relevance 0.42
T lymphocytes from blood and BAL samples from COPD patients have increased levels of GRZ and perforin compared to samples from asymptomatic smokers and nonsmokers (Hodge et al 2006).
Positive_regulation (increased) of perforin in blood associated with nicotine addiction and pulmonary disease
12) Confidence 0.03 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.23 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox