INT57960

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Context Info
Confidence 0.24
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ligase activity (Gss)
Anatomy Link Frequency
liver 1
Gss (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 98.32 Very High Very High Very High
Cancer 1 49.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prolonged paracetamol challenge (0.6% diet for 10 days) elevated liver cytosolic GSH-S-transferase activity (GST) two-fold and decreased liver GSH to 46% of control values.
Positive_regulation (elevated) of GSH-S-transferase activity in liver associated with paracetamol
1) Confidence 0.24 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8237062 Disease Relevance 0 Pain Relevance 0.45
In addition, AF prevented hepatic glutathione (GSH) depletion by APAP, and hepatic GSH levels and GSH S-transferase activities were up-regulated by AF.
Positive_regulation (up-regulated) of GSH S-transferase
2) Confidence 0.11 Published 2009 Journal J Med Food Section Abstract Doc Link 19459732 Disease Relevance 0.26 Pain Relevance 0.16

General Comments

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