INT57970

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 7.03
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
sensory neuron 1
Macrophages 1
brain 1
epithelial cell 1
annulus 1
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 11 99.32 Very High Very High Very High
imagery 256 97.88 Very High Very High Very High
cINOD 10 97.64 Very High Very High Very High
Inflammation 81 95.56 Very High Very High Very High
ischemia 100 92.88 High High
Somatosensory cortex 55 90.64 High High
interneuron 14 86.64 High High
antagonist 5 84.44 Quite High
Glutamate receptor 8 83.96 Quite High
withdrawal 6 81.60 Quite High
Disease Link Frequency Relevance Heat
Stroke 345 100.00 Very High Very High Very High
Cancer 223 100.00 Very High Very High Very High
Retinoblastoma 13 100.00 Very High Very High Very High
Shock 8 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 40 99.60 Very High Very High Very High
Skin Cancer 10 97.80 Very High Very High Very High
INFLAMMATION 91 97.40 Very High Very High Very High
Repression 13 96.72 Very High Very High Very High
Cv Unclassified Under Development 100 92.88 High High
Glioma 1 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our analysis identified significant upregulation of the retinoblastoma (Rb)-associated KRAB repressor gene (also called RBAK) in senescent annulus cells compared to levels in non-senescent cells.
Positive_regulation (upregulation) of retinoblastoma in annulus associated with retinoblastoma
1) Confidence 0.67 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.73 Pain Relevance 0.04
In some cases to reduce background due to extravasation, the TR-dextran was injected after RB stroke induction.
Positive_regulation (induction) of RB associated with stroke
2) Confidence 0.60 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.28 Pain Relevance 0.14
Because of potential for redundant pathways for blood flow (and even flow reversals) [16], we found it necessary to photoactivate RB within at least two points along the arterial branch.
Positive_regulation (photoactivate) of RB in blood
3) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.40 Pain Relevance 0.12
Previous control experiments indicate that clotted vessels and beaded dendrites were attributed to RB photoactivation since the green activating light alone had no effect [15].
Positive_regulation (photoactivation) of RB in vessels
4) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.31 Pain Relevance 0.19
The anti-angiogenic effects of TSP1 may also be CD36 independent, it suppresses the cell cycle, increasing p21 and unphosphorylated retinoblastoma (Rb) in EC.(34) Many receptors interact with specific binding sites of TSP1.
Positive_regulation (increasing) of retinoblastoma associated with retinoblastoma
5) Confidence 0.45 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.48 Pain Relevance 0.07
Although this is a concern, the columnar organization of the brain and our observations that stroke damage is radially oriented in the RB and even MCAO models [18], suggests that surface morphology and lack of function are indicative of deeper layers.
Positive_regulation (oriented) of RB in brain associated with middle cerebral artery infarction and stroke
6) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.20 Pain Relevance 0.12
To produce targeted strokes using photothrombosis, RB was delivered by tail vein injection and activated using a green light source over the cortical territories of interest.
Positive_regulation (activated) of RB in tail vein associated with stroke
7) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1854912 Disease Relevance 0.40 Pain Relevance 0.23
SAHA treatment resulted in G1 cell growth arrest in TM10 and TM2H cell lines, concomitant with the profound increase in dephosphorylation of the three pRb pocket proteins.
Positive_regulation (increase) of pRb
8) Confidence 0.41 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.09 Pain Relevance 0
Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.



Positive_regulation (induction) of pRb in epithelial cell associated with repression
9) Confidence 0.41 Published 2001 Journal Breast Cancer Res Section Title Doc Link PMC13923 Disease Relevance 0.10 Pain Relevance 0
Macrophages exposed to cocaine in vitro failed to respond by an increase in RB.
Positive_regulation (increase) of RB in Macrophages associated with cocaine
10) Confidence 0.41 Published 1993 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8237588 Disease Relevance 0 Pain Relevance 0.52
Five Ela-myc tumors were sequenced for the coding region of the Rb gene.
Positive_regulation (sequenced) of Rb associated with cancer
11) Confidence 0.32 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.46 Pain Relevance 0
The p15ink4b protein phosphorylates and inactivates the retinoblastoma tumor suppressor (pRb) protein [22].
Positive_regulation (inactivates) of pRb associated with cancer and retinoblastoma
12) Confidence 0.26 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 0.63 Pain Relevance 0.03
pathology but induced an elevation in the number of phosphorylated retinoblastoma (pRb) tumor suppressor protein and active caspase-3 immunopositive neurons [346].
Positive_regulation (induced) of pRb in neurons associated with cancer and retinoblastoma
13) Confidence 0.11 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 1.59 Pain Relevance 0.53
The inaccessibility of more ventral descending interneurons (dINs) and motoneurons (mns) prevented paired recordings with RBs, so we electrically stimulated RB neurites in the skin.
Positive_regulation (stimulated) of RB in neurites
14) Confidence 0.03 Published 2007 Journal Neural Develop Section Body Doc Link PMC2071915 Disease Relevance 0 Pain Relevance 0.34
They are higher for RB sensory neuron contacts onto sensory pathway dlcs (0.65) than onto other neurons like dINs (0.29); they are low for dlc contacts with each other (0.08) but higher onto the neurons activated after skin stimulation (0.54–0.89 for aINs, cINs, dINs and mns); they are quite high for contacts between neurons active during swimming (0.5–0.91 for aIN, cIN and dIN contacts to each other and to mns).
Positive_regulation (higher) of RB in sensory neuron
15) Confidence 0.03 Published 2007 Journal Neural Develop Section Body Doc Link PMC2071915 Disease Relevance 0 Pain Relevance 0
USC-HN1 cells demonstrate strong, uniform nuclear p53 and Rb expression, as well as positive expression of keratin, E-cadherin, EGFr, and CD44 in situ consistent with HNSCC as well as the original tumor biopsy [4,7,13,19].
Positive_regulation (nuclear) of Rb associated with cancer
16) Confidence 0.02 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.12 Pain Relevance 0
Although NCoA6 was initially cloned as coactivator protein for NRs, its detailed characterization by a number of laboratories has uncovered its potential to enhance the activity of a wide variety of other transcription factors including c-Fos, c-Jun, CREB, NF-kB, ATF-2, heat shock factors, E2F-1, SRF, and Rb, p53 and Sox9 [Goo et al., 2004; Hong et al., 2004a; Hong et al., 2004b; Ko et al., 2000; Kong et al., 2003; Lee et al., 1999; Lee et al., 2000; Mahajan et al., 2007; Mahajan et al., 2002; Mahajan and Samuels, 2000; Mahajan and Samuels, 2005].
Positive_regulation (enhance) of Rb associated with shock
17) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox