INT57971

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Context Info
Confidence 0.41
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.36
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
pituitary 1
intestine 1
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 12 99.84 Very High Very High Very High
cocaine 11 99.58 Very High Very High Very High
opiate 2 91.84 High High
Action potential 4 86.40 High High
Glutamate 4 84.12 Quite High
headache 1 78.84 Quite High
Crohn's disease 1 72.92 Quite High
local anesthetic 1 68.76 Quite High
Catecholamine 2 57.80 Quite High
Spinal cord 38 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 27 99.28 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 8 99.16 Very High Very High Very High
Adenoma 4 92.96 High High
Cancer 5 86.08 High High
Obesity 2 80.44 Quite High
Hypopituitarism 1 79.52 Quite High
Headache 1 78.84 Quite High
Syndrome 1 76.16 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 73.24 Quite High
Disease 3 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These experiments were conducted to determine the effects of the ginsenosides Rb1 and Rg1, major components of the protopanaxadiol and protopanaxatriol fractions of ginseng saponin, on morphine-induced hyperactivity and conditioned place-preference.
Spec (determine) Regulation (effects) of Rb1 associated with attention deficit hyperactivity disorder and morphine
1) Confidence 0.41 Published 1998 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9643450 Disease Relevance 0.34 Pain Relevance 0.44
However, the classical gene alterations involved in cell transformation, such as ras, BRAF, Rb, do not appear to be responsible for the onset of pituitary adenomas [3].
Regulation (responsible) of Rb in pituitary associated with pituitary cancer
2) Confidence 0.40 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 1.21 Pain Relevance 0.08
Effects of the ginsenosides Rg1 and Rb1 on morphine-induced hyperactivity and reinforcement in mice.
Regulation (Effects) of Rb1 associated with attention deficit hyperactivity disorder and morphine
3) Confidence 0.30 Published 1998 Journal J. Pharm. Pharmacol. Section Title Doc Link 9643450 Disease Relevance 0.34 Pain Relevance 0.49
Intraperitoneal injection of cocaine metabolites did not affect the RB.
Neg (not) Regulation (affect) of RB associated with cocaine
4) Confidence 0.24 Published 1993 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8237588 Disease Relevance 0 Pain Relevance 0.53
CCNA1 belongs to the cyclin family, and binds to important cell cycle regulators such as E2F, Rb, CDK2 and p21, but its abundance in the intestine is low [34].
Regulation (regulators) of Rb in intestine
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0.39 Pain Relevance 0.04
The response of each network to a single stimulus to the sensory RB was then tested once.
Regulation (response) of RB
6) Confidence 0.02 Published 2007 Journal Neural Develop Section Body Doc Link PMC2071915 Disease Relevance 0 Pain Relevance 0.09

General Comments

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