INT57985

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.66
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b, Il6) aging (Il1b, Il6) extracellular region (Il1b, Il6)
Anatomy Link Frequency
brain 2
Il1b (Rattus norvegicus)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 3 99.92 Very High Very High Very High
antagonist 13 99.84 Very High Very High Very High
Morphine 2 99.66 Very High Very High Very High
Eae 7 99.20 Very High Very High Very High
Endogenous opioid 2 97.96 Very High Very High Very High
corticosteroid 2 97.16 Very High Very High Very High
dexamethasone 2 96.88 Very High Very High Very High
Opioid 1 95.40 Very High Very High Very High
cytokine 4 95.08 Very High Very High Very High
opiate 8 94.88 High High
Disease Link Frequency Relevance Heat
Injury 8 99.20 Very High Very High Very High
Acute-phase Reaction 4 92.20 High High
INFLAMMATION 3 89.76 High High
Hyperalgesia 2 82.40 Quite High
Neuropathic Pain 4 81.72 Quite High
Pain 1 78.40 Quite High
Nervous System Injury 1 75.12 Quite High
Nociception 1 67.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results show that induction of high serum IL-6 levels by central IL-1 beta is mediated by brain IL-1 receptors and is sensitive to inhibition by corticosteroids.
IL-1 beta Positive_regulation (induction) of IL-6 in brain associated with corticosteroid
1) Confidence 0.59 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8238440 Disease Relevance 0.07 Pain Relevance 0.59
Moreover, morphine potentiated the IL-6 response induced by IL-1 beta (400 ng, i.p. or i.c.v.).
IL-1 beta Positive_regulation (induced) of IL-6 associated with morphine
2) Confidence 0.42 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817528 Disease Relevance 0.18 Pain Relevance 0.91
Neither antiserum against corticotropin-releasing factor (CRF) nor the alpha-helical-CRF antagonist (25 micrograms/rat icv) affected IL-6 induction by central IL-1 beta, which, however, was significantly prevented by the synthetic glucocorticoid dexamethasone [3 mg/kg intraperitoneally (ip)].
IL-1 beta Neg (Neither) Positive_regulation (induction) of IL-6 associated with antagonist and dexamethasone
3) Confidence 0.40 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8238440 Disease Relevance 0.09 Pain Relevance 0.44
Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1 beta with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine.
IL-1 beta Positive_regulation (induction) of IL-6 in brain associated with antagonist, endogenous opioid and cytokine
4) Confidence 0.29 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321873 Disease Relevance 0.14 Pain Relevance 0.62
IL-1beta and IL-6 mRNAs were strongly ipsilaterally elevated on day seven after CCI.
IL-1beta Positive_regulation (elevated) of IL-6 associated with eae
5) Confidence 0.05 Published 2008 Journal Pain Section Abstract Doc Link 18374486 Disease Relevance 1.19 Pain Relevance 0.97

General Comments

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