INT57986

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b, Il6) aging (Il1b, Il6) extracellular region (Il1b, Il6)
Anatomy Link Frequency
brain 2
Il1b (Rattus norvegicus)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 7 99.98 Very High Very High Very High
Endogenous opioid 2 97.96 Very High Very High Very High
dexamethasone 1 96.88 Very High Very High Very High
Opioid 1 95.68 Very High Very High Very High
cytokine 2 95.08 Very High Very High Very High
narcan 4 89.92 High High
opiate 2 88.80 High High
opioid receptor 2 75.00 Quite High
Intracerebroventricular 1 73.12 Quite High
Hippocampus 1 67.28 Quite High
Disease Link Frequency Relevance Heat
Acute-phase Reaction 2 91.36 High High
INFLAMMATION 1 66.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither antiserum against corticotropin-releasing factor (CRF) nor the alpha-helical-CRF antagonist (25 micrograms/rat icv) affected IL-6 induction by central IL-1 beta, which, however, was significantly prevented by the synthetic glucocorticoid dexamethasone [3 mg/kg intraperitoneally (ip)].
IL-1 beta Neg (Neither) Regulation (affected) of Neg (Neither) Positive_regulation (induction) of IL-6 associated with antagonist and dexamethasone
1) Confidence 0.39 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8238440 Disease Relevance 0.09 Pain Relevance 0.44
Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1 beta with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine.
IL-1 beta Regulation (affect) of Positive_regulation (induction) of IL-6 in brain associated with antagonist, endogenous opioid and cytokine
2) Confidence 0.28 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321873 Disease Relevance 0.14 Pain Relevance 0.62

General Comments

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